Vol 17, No 4 (2012)

The nucleotide sequence of M= (1398 nucleotides and L= (6186 nucleotides) segments of the genome of Bhanja virus and L-segment (1297 nucleotides) of Kismayo virus has been partially determined. Phylogenetic analysis of deduced amino acid sequences showed that these viruses are novel members of the Flebovirus (Phlebovirus) genus in the family Bunyaviridae

The aim of the work was the study of serum from patients with suspected dengue fever by both enzyme immunoassay and immunochromatography. Markers of dengue fever were detected in 6 of 10 travelers returning from Southeast Asia. Analysis of the of immunoglobulin M and G antibody titers ratio (IgG/IgM) showed that the five travelers were infected with dengue fever virus for the first time. At the same moment one of patients was infected with dengue virus repeatedly that is a risk factor for severe complications. Thus, early laboratory diagnosis of dengue based on the detection of NSl=antigen and IgG/IgM ratio has been shown not only to help in making a differential diagnosis, but also in saving the life of the patient, because the dengue fever is characterized by rapid progression to the development of severe complications which are not compatible with life. In cases of fever in travelers which have been coming back from countries where hemorrhagic fever is endemic, we propose to make a differential diagnosis with dengue fever that was confirmed by our study.

A study on the phospholipid content and the process of peroxidation of phospholipids in erythrocyte membranes of patients with liver ehinokkom patients before surgery and after surgery for 3—10 days. Found to change in the qualitative and quantitative content of phospholipids and activation of free radical processes in patients with hepatic echinococcosis before operation. After surgery, the 10 day trend towards normalization of the studied processes.

A case of loaosis in a female tourist from the Bryansk region, which visited Equatorial Guinea, has been described. The clinical picture of the disease was characterized by recurrent ‘tumor de Calabar’ (ambulant edema) in different parts of the body, migration of helminth beneath of eye serous membrane and high eosinophilia. The patient was successfully cured with the use of combination therapy consisting of sequential taking albendazole and ivermectin treatment. For the prevention of adverse reactions during all the period of treatment with albendazole and ivermectin the patient received glucocorticosteroid medication. 2-year dispensary observation showed adequately treatment of the patient, the absence of relapse and normalization of eosinophil count in the peripheral blood. We discuss the objective complexity of the parasitological confirmation of loaosis and the problem of prevention of tropical diseases in backpacking tourists.

N THE STUDY THE ANALYSIS OF INDICATORS OF ANTIOXIDANT DEFENSE IN INFLUENZA HAS BEEN PERFORMED. THE REGULARY INHIBITION OF CERULOPLASMIN WITH A MAXIMUM REDUCTION IN THE ERUPTIVE PHASE OF CLINICAL MANIFESTATION OF INFLUENZA AND REGULAR SIGNIFICANT INCREASE IN ERYTHROCYTE CATALASE ACTIVITY WITH A MAXIMUM VALUE AT THE HEIGHT OF THE DISEASE HAS BEEN ESTABLISHED. DURING EXTINCTION OF CLINICAL SYMPTOMS, THE GRADUAL INCREASE IN THE ACTIVITY OF CERULOPLASMIN IN THE BLOOD PLASMA WITH A SIGNIFICANT DECLINE IN CATALASE ACTIVITY OF ERYTHROCYTES TOOK PLACE. AT THE EARLY CONVALESCENCE STAGE CERULOPLASMIN ACTIVITY IN PLASMA CONTINUED TO INCREASE, AND THE LEVEL OF ERYTHROCYTE CATALASE ACTIVITY REMAINED SIGNIFICANTLY ELEVATED. NORMALIZATION OF ERYTHROCYTE CATALASE ACTIVITY IN RED BLOOD CELLS OCCURRED IN THE EARLY PERIOD OF CONVALESCENCE. CHANGES IN INDICATORS OF THE ANTIOXIDANT DEFENSE IN THE DYNAMICS OF INFLUENZA DEPENDED ON THE STAGE, SEVERITY AND CHARACTER OF COMPLICATIONS AND CONCOMITANT DISEASES.

The aim: Introduction of advanced-level training cycles (ALTC) in the form of online mode distance education on actual questions of infectology and the evaluation of their effectiveness in the postgraduate training of doctors. Giving ALTC in the form of online mode distance education (full, partial) on the actual questions of infectology is based on phasing and systemity of ongoing project and should include five basic steps: defining the aim of the project and the participants of its implementation, delivering information resources and development of electronic versions of educational and resource materials, contractual process with the customer, Internet Service Provider and technical testing of telecommunication systems, the direct holding of distance cycle, expert evaluation of the quality of distance learning. Implementation of online mode distance learning assumes the use of modern information and telecommunication resources, interactive technologies, clear organizational and administrative decisions, professionalism of teachers, the interaction of all the participants in the educational process (including doctors pariticipants) and should be completed with the resulting expertise.

With the use a comparative historical and cartographic technique in an epidemiological study of materials on cholera, concomitant natural and social factors in the period up to 1817, this article considers the etymological carriers of the ancient Greek word "cholera" not as an infectious process, but as the epidemic process. This provided a clarification of the epidemiological characteristics of historical cholera in the Eurasian continent.