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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Epidemiology and Infectious Diseases</journal-id><journal-title-group><journal-title xml:lang="en">Epidemiology and Infectious Diseases</journal-title><trans-title-group xml:lang="ru"><trans-title>Эпидемиология и инфекционные болезни</trans-title></trans-title-group></journal-title-group><issn publication-format="print">3034-2007</issn><issn publication-format="electronic">3034-2015</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">40635</article-id><article-id pub-id-type="doi">10.17816/EID40635</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Dengue fever in the Russian Federation in travelers, returning from Southeast Asia in 2010-2011</article-title><trans-title-group xml:lang="ru"><trans-title>Случаи лихорадки денге на территории РФ в 2010—2011 гг. среди туристов, вернувшихся из юго-восточной Азии</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Berillo</surname><given-names>S. A</given-names></name><name xml:lang="ru"><surname>Берилло</surname><given-names>Сания Александровна</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант, мл. науч. сотр. отдела "Коллекция микроорганизмов"</p></bio><email>berillo@vector.nsc.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Demina</surname><given-names>O. K</given-names></name><name xml:lang="ru"><surname>Демина</surname><given-names>Ольга Константиновна</given-names></name></name-alternatives><bio xml:lang="ru"><p>науч. сотр. отдела "Коллекция микроорганизмов"</p></bio><email>demina@vector.nsc.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Ternovoy</surname><given-names>V. A</given-names></name><name xml:lang="ru"><surname>Терновой</surname><given-names>Владимир Александрович</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. биол. наук, зав. лаб. молекулярной эпидемиологии особо опасных инфекций</p></bio><email>tern@vector.nsc.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shikov</surname><given-names>A. N</given-names></name><name xml:lang="ru"><surname>Шиков</surname><given-names>Андрей Николаевич</given-names></name></name-alternatives><bio xml:lang="ru"><p>науч. сотр. отд. "Коллекция микроорганизмов"</p></bio><email>shikov_nsk@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sergeeva</surname><given-names>E. I</given-names></name><name xml:lang="ru"><surname>Сергеева</surname><given-names>Елена Игоревна</given-names></name></name-alternatives><bio xml:lang="ru"><p>науч. сотр. отд. "Коллекция микроорганизмов"</p></bio><email>esergeeva@vector.nsc.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Demina</surname><given-names>A. V</given-names></name><name xml:lang="ru"><surname>Демина</surname><given-names>Анна Владимировна</given-names></name></name-alternatives><bio xml:lang="ru"><p>мл. науч. сотр. лаб. молекулярной эпидемиологии особо опасных инфекций</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kostina</surname><given-names>N. E</given-names></name><name xml:lang="ru"><surname>Костина</surname><given-names>Нина Егоровна</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. биол. наук, ст. науч. сотр. отд. " Коллекция микроорганизмов"</p></bio><email>nekostina@vector.nsc.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Vinokurova</surname><given-names>A. V</given-names></name><name xml:lang="ru"><surname>Винокурова</surname><given-names>Анна Вячеславовна</given-names></name></name-alternatives><bio xml:lang="ru"><p>мл. науч. сотр. отд."Коллекция микроорганизмов"</p></bio><email>vinokurova_av@vector.nsc.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Mikheev</surname><given-names>V. N</given-names></name><name xml:lang="ru"><surname>Михеев</surname><given-names>Валерий Николаевич</given-names></name></name-alternatives><bio xml:lang="ru"><p>канд. мед. наук, зам. генерального директора по научной и эпидемиологической работе</p></bio><email>vn_mikheev@vector.nsc.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Agafonov</surname><given-names>A. P</given-names></name><name xml:lang="ru"><surname>Агафонов</surname><given-names>Александр Петрович</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор биол. наук, зам. генерального директора по научной работе</p></bio><email>agafonov@vector.nsc.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Sergeev</surname><given-names>A. N</given-names></name><name xml:lang="ru"><surname>Сергеев</surname><given-names>Александр Николаевич</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор мед. наук, проф., генеральный директор</p></bio><email>an_sergeev@vector.nsc.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ФБУН Государственный научный центр вирусологии и биотехнологии "Вектор"</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2012-08-15" publication-format="electronic"><day>15</day><month>08</month><year>2012</year></pub-date><volume>17</volume><issue>4</issue><issue-title xml:lang="en">NO4 (2012)</issue-title><issue-title xml:lang="ru">№4 (2012)</issue-title><fpage>12</fpage><lpage>15</lpage><history><date date-type="received" iso-8601-date="2020-07-23"><day>23</day><month>07</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2012, Eco-vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2012, ООО "Эко-вектор"</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="en">Eco-vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://rjeid.com/1560-9529/article/view/40635">https://rjeid.com/1560-9529/article/view/40635</self-uri><abstract xml:lang="en"><p>The aim of the work was the study of serum from patients with suspected dengue fever by both enzyme immunoassay and immunochromatography. Markers of dengue fever were detected in 6 of 10 travelers returning from Southeast Asia. Analysis of the of immunoglobulin M and G antibody titers ratio (IgG/IgM) showed that the five travelers were infected with dengue fever virus for the first time. At the same moment one of patients was infected with dengue virus repeatedly that is a risk factor for severe complications. Thus, early laboratory diagnosis of dengue based on the detection of NSl=antigen and IgG/IgM ratio has been shown not only to help in making a differential diagnosis, but also in saving the life of the patient, because the dengue fever is characterized by rapid progression to the development of severe complications which are not compatible with life. In cases of fever in travelers which have been coming back from countries where hemorrhagic fever is endemic, we propose to make a differential diagnosis with dengue fever that was confirmed by our study.</p></abstract><trans-abstract xml:lang="ru"><p>В ходе исследования методом иммунохроматографии и иммуноферментного анализа у 6 из 10 туристов с клиническими признаками лихорадки денге, вернувшихся из Юго-Восточной Азии в 2010—2011 гг., был обнаружен NSl-антиген вируса денге, а также IgM и IgG к вирусу денге. Анализ соотношения титров иммуноглобулинов M и G показал, что 5 туристов лихорадкой денге заболели впервые, а 1 — повторно, что является фактором риска развития тяжелых осложнений. Таким образом, своевременная лабораторная диагностика, основанная как на выявлении NS1-антигена вируса денге, так и на определении соотношения иммуноглобулинов классов M и G, не только помогает провести дифференциальный диагноз, но и спасти жизнь пациенту, так как для повторного заболевания лихорадкой денге в случае отсутствия лечебных мероприятий характерно быстрое прогрессирование с развитием тяжелых осложнений, не совместимых с жизнью. При наличии лихорадки у туристов, вернувшихся из стран, эндемичных по геморрагическим лихорадкам, дифференциальный диагноз рекомендуется проводить с лихорадкой денге, что подтверждают проведенные в данной работе исследования.</p></trans-abstract><kwd-group xml:lang="en"><kwd>Southeast Asia</kwd><kwd>travelers</kwd><kwd>dengue fever</kwd><kwd>diagnosis</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>Юго-Восточная Азия</kwd><kwd>туристы</kwd><kwd>лихорадка денге</kwd><kwd>диагностика</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Каталог продукции ООО "ИнтерЛабСервис" // Сайт ИЛС. URL: http://www.interlabservice.ru/catalog/reagents/index.php? sid=678</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Chanama S., Anantapreecha S., Nuegoonpipat A. et al. Analysis of specific IgM responses in secondary dengue virus infections: levels and positive rates in comparison with primary infections // J. Clin. Virol. — 2004. — Vol. 31. — P. 185—189.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Guzman M.G. Effect of age on outcome of secondary dengue 2 infections // Intern. J. Infect. Dis. — 2002. — Vol. 6. — P. 118—124.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Halstead S.B. Etiologies of the experimental dengues of Siler and Simmons // Am. J. Trop. Med. Hyg. — 1974. — Vol. 23. — P. 974—982.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Halstead S.B. Pathophysiology and pathogenesis of dengue haemorrhagic fever // Monograph on Dengue/Dengue Haemorrhagic Fever / Ed. P. Thongchareon. — New Delhi, 1993. — P. 80—103.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Innis B. An enzyme-linked immunosorbent assay to characterize dengue infections where dengue and Japanese encephalitis cocirculate // Am. J. Trop. Med. Hyg. — 1989. — Vol. 40. — P. 418—427.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Jelinek T. Trends in the epidemiology of dengue fever and their relevance for importation to Europe // Euro Surveill. 2009; 14 (25): pii = 19250. URL: http://www.eurosurveillance.org/ ViewArticle.aspx?ArticleId=19250.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Kuno G., Gomez I., Gubler D.J. An ELISA procedure for the diagnosis of dengue infections // J. Virol. Meth. — 1991. — Vol. 33. — P. 101—113.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>PAHO. Dengue and Dengue Hemorrhagic Fever in the Americas: Guidelines for Prevention and Control. (Scientific Publication N 548). — Washington, 1994.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Runge-Ranzinger S., Horstrick O., Marx M., Kroeger A. What does dengue disease surveillance contribute to predicting and detecting outbreaks and describing trends? // Trop. Med. Int. Hlth. — Vol. 13. — P. 1022—1041.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Sangkawibha N. Risk factors in dengue shock syndrome: a prospective epidemiologic study in Rayong, Thailand. I. The 1980 outbreak // Am. J. Epidemiol. — 1984. — Vol. 120. — P. 653—669.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Shu Pei-Yun, Chen Li-Kuang, Chang Shu-Fen. Comparison of a capture immunoglobulin M (IgM) and IgG ELISA and non-structural protein NS1 serotype-specific IgG ELISA for differentiation of primary and secondary dengue virus infections // Clin. Diagn. Lab. Immunol. — 2003. — Vol. 10. — P. 622—630.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>WHO. Dengue and dengue haemorrhagic fever // Factsheet No 117, revised январь 2012. Geneva. World Health Organization, 2012. URL: http://www.who.int/mediacentre/factsheets/fs117/en/.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>WHO. Dengue Haemorrhagic Fever: Diagnosis, Treatment, Prevention and Control. — 2nd Ed. Geneva, 1997.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>World Health Organization. Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control. — New Ed. — , 2009.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>WHO/SEARO. Situation update of dengue in the SEA Region, 2010 // World Health Organization Regional Office for South-East Asia, 2011. URL: http://www.searo.who.int/en/Section10/ Section332.htm</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>WHO/SEAR. Trend of Dengue case and CFR in SEAR Countries // World Health Organization Regional Office for South-East Asia, 2011. URL: http://www.searo.who.int/en/Section10/ Section332/ Section2277_11964.htm</mixed-citation></ref></ref-list></back></article>
