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Author Guidelines

In preparing the manuscript, authors should follow the Recommendations for the Conduct, Reporting, Editing and Publication of Scholarly Work in Medical Journals of the International Committee of Medical Journal Editors.

The Editorial Board can check the material using the Anti-Plagiarism system. In the case of multiple borrowings, the Editorial Board operates in accordance with COPE rules.

Instructions for Authors

1. We accept submissions strictly online, via the form available at our website.

   Please fill in complete information about the authors.

   Please upload your manuscript as a Microsoft Office Word document (*.doc, *.docx or *.rtf formats).

   Supplementary materials (figures) should be submitted as separate files with an appropriate caption (e.g.: “Fig. 3. Mutation rate”).

2. An article must be typed in a 14 pitch-font, double-spaced on A4 paper (210x297 mm) with 2.5-cm margins on both sides of the text. All components of the article, except figures, must be submitted in a single electronic file.

The title page should contain: 1) an informative and rather concise title of the article; 2) the authors’ initials and surnames; 3) the official name of an affiliation and establishment, in which the work has been done; 4) academic degrees, academic ranks, positions, and place of employment (required with mailing address) of all authors; 5) the surname, name, patronymic, e-mail, and mobile phone of the author responsible for communicating with the editorial office; 6) a short running title of 5-6 words to be placed on the page of the journal; 7) information on funding sources; 8) information on a possible conflict of interest.

3. Publication of articles is free of charge.

4. The article must be signed by all authors. It is imperative that the surname, name, patronymic of the author, with whom the journal’s editors will correspond, his/her address (with postcode), e-mail address, and phone number, be specified. If the authors of the article have different affiliations, contact information (e-mail) should be given for each organization.

Be sure to indicate an ORCID identifier for an author who submits an article and it is desirable to do this for each author of the article. If the ORCID identifier is absent, it should be obtained by registering on the website ORCID is a registry of unique identifiers of scientists and at the same time an appropriate method of linking their research activities to these identifiers. Today it is the only way to uniquely identify the personality of a scientist, especially in situations with full coincidence of the authors’ surname, name, and patronymic.

5. An original article should not exceed 15 pages (1800 characters including spaces per page) and should contain no more than 5-6 figures. A review should have 12-18 pages. Larger-volume articles describing original investigations are individually allowed by the decision of the Editorial Board. The number of figures and tables should correspond to the quantity of the provided information, according to the principle of necessary-and-sufficient relations. The data given in the tables should not duplicate those in the figures and text, and vice versa. Remember that the redundancy of illustrative material may entail a return of the article to the authors for reduction.

6. The article must have an abstract (in Russian and English) of 200 to 250 words, the beginning of which should completely repeat the title, the surnames of authors and their affiliation. For the correctness of the information provided, we recommend that authors should check the English spelling of the name of the institution on the website https://grid.acThe abstract should be structured and contain the following subsections: objective, subjects/materials and methods, results, and conclusion. The abstract should briefly present the results of an investigation, a description of its design, groups, and its results with the main digital data. At the end of the abstract there should be 3-5 keywords that promote the indexing of the article in the information retrieval systems. Emphasis should be placed on the new and important aspects of an investigation or observations.

7. The article should be carefully edited and verified by the author. The description must be clear, without long introductions and repetitions. 

8. Citations given in the article should be carefully checked; a footnote should indicate a reference, its title, year, issue, pages.

9. Abbreviations and acronyms, other than conventional abbreviations of chemical and mathematical variables, and terms are not allowedThe SI system should be used in the article.

10. Technical terms should be translated into Russian; and only words generally accepted in the scientific literature should be usedForeign words in the authors’ “own” Russian transcription should not be used in any case. Chemical formulas, doses are signed by the author on the margins. It is desirable to prepare mathematical formulas by using specialized mathematical software tools or Equation editors.

Articles presenting original investigations should contain the following clearly delineated sections: 1. Objective; 2. Subjects/Materials and methods; 3. Results; 4. Discussion; 5. Conclusion; 6. References. Section 3 may be combined with Section 4, i.e. Results and discussion.

The review paper should contain at least 70 references.

Introduction. This section briefly describes the problem with references to the most significant publications and states the need for an investigation.

Objective. This section contains 2-3 sentences that state what problem or hypothesis and for what purpose the author solves.

Subjects/Materials and methods. This section includes a detailed description of methods, the equipment used in an investigation, criteria for selection of animals and patients, the number and characteristics of patients with their distribution by gender and age, if required for the investigation. It must specify the principle of patient division into groups, as well as the design of the study. All study drugs and chemicals, including their international non-proprietary (common) name, doses, and routes of administration, should be given. This section should contain maximum information as necessary for further possible reproduction of results by other investigators, for comparison of the results of similar investigations, and for possible inclusion of these articles in a meta-analysis.

Herein, there is an indication of the adherence to both local and international ethical principles (compliance with the ethical principles of the European Convention for the Protection of Vertebrate Animals; Declaration of Helsinki; a patient’s informed consent). See “Ethical principles” for details.

At the end of this section, there is the subsection “Data processing” that indicates what data processing methods the author has used. If the study has been randomized, the principle of randomization is specified. Mean values are presented as M±m where M is the average arithmetic mean; m is the standard error of the mean. When displaying significance levels, it is desirable to give the exact p-value (p =... rather than p <...) in the text of the article and tables. Correlation coefficients should be given, indicating only their statistical significance, i.e. with the p-value, for example, r = 0.435; p = 0.006.

Results. Findings should be presented in a logical sequence with no references. Data are given very clearly as short descriptions with graphs, tables, and figures (do not duplicate data; there is only one way of their presentation!).

Percentages should be presented in the text of the article or tables, by simultaneously indicating the absolute value of the quantity that is taken as 100%, for example, 25% of the 120 patients. Another way is to show both the percentage and absolute values; for example 25% (30/120) or 30 (25%) of the 120 patients.

If there is a successive percentage recalculation, i.e. calculation of the percent of a percent (the percent of the number of study subjects/objects in the subgroup previously described in terms of percentages), it is necessary to clearly describe this procedure and to display the number of study subjects/objects, which are taken sequentially as 100%.

The required accuracy of the given percentage depends on the sample size:

  • the so-called small samples (less than 20 study subjects/objects) are not generally accepted to be described in terms of percentages (since the percent value is found to be much greater than the absolute number of study subjects/objects in such cases). In these cases, absolute frequencies are indicated for the values of a particular characteristic.
  • if the sample consists of 20 to 100 study subjects/objects, the percentages are presented as whole numbers.
  • if the sample includes more than 100 study subjects/objects, the percentage is given with no more than one decimal digit.

Discussion. You should identify the new and important aspects of the results of the study performed, to analyze the possible mechanisms or interpretations of these findings, and to compare them with the data obtained by other investigators, wherever possible. The information already given in the section “Introduction” and the detailed data in the section “Results” should not be repeated. The discussion may include sound recommendations for clinical practice and the possible application of obtained results in future investigations.

Conclusion. One or two sentences should summarize the results of the work: what has been obtained, what this may suggest, or what this may mean, what purpose this serves, and what possibilities this reveals. You should reflect the prospects for using your results. You should avoid claiming priority and referring to your completed work.

11. Only the international CEAP classification should be used in the articles characterizing your own clinical material.

12. Tables should be clearly constructed and have a heading and a serial number; their headings should accurately match the content of columns. All figures, totals, and percentages in the tables must be carefully checked by the author and must correspond to those in the text. The latter must indicate the place of a table and its serial number. 
Signatures and all text data must be sent in Russian and English!

13. The number of illustrations (photos, figures, drawings, and diagrams) should be absolutely necessary (no more than 5-6).

All figures should be inserted in the text of the article and provided in electronic format: a) scanned photos, images, and figures (raster images) which have a format, such as .jpg, .png .tif.; b) graphs, charts, and other illustrations prepared using computer programs should be submitted in the vector format: pdf, ai, svg, or Postscript. If the graphs are not provided in the vector format, the editors have the right to request the file in the format of the program in which it has been done, for example, in PowerPoint, Excel (this is required to verify the image originality). Figures submitted in Microsoft Word are not acceptable!

The raster images should have a resolution of 300 dpi or at least 1000 pixels on the long side. The full-screen image should be clear; the text easily readable. Captions, numbers, markers, and letters (a, b, c, etc.) within the figure should not be located over the important parts of an image. The text size should be at least 6 points; the text should be typed in the same font and in the same type size throughout the article.

If the original illustrations are color and are published in a black-and-white journal, they should be turned into black and white so that to avoid the possible loss of informative value. It is recommended that such illustrations be printed to a black-and-white printer to check if it is grayscale and the indications of color in the figure captions be avoided. It is especially important to track the graphs and diagrams in which a large number of colors are used. In such cases, the color should be replaced by numbers or symbols or the colors should be converted to black-and-white patterns of hatching or shades of gray. The black-and-white charts, graphs, and diagrams should not use more than 5 shades of gray, including black and white.

Portraits should be full-face. They should have a vertical position. The face must not be against a dark background. The background should not contain interior design items merging in tone with the face and clothing. The portraits for articles dedicated to anniversaries and obituaries must have a resolution of 300 dpi with a width of 50 mm.

It is prohibited:

  • a.To submit illustrations that may be used to identify a patient without his/her informed consent.
  • b.To submit illustrations taken from previously published sources (including the Internet) without written permission from the author/rightholder. The exception is CC-BY images that may be published citing the source.
  • c.To use three-dimensional bar charts and circle diagrams.
  • d.To submit low-informative graphs that reflect less than 6 digital values; they should be converted to the text.

14. Figure captions should be numbered; the place for a figure must be indicated in the text. The captions should provide an explanation of the meanings of all curves, letters, figures, and other reference designations. 
Captions for figures and photos, notes must be in Russian and English.

15. References

A list of references should be typed on a separate sheet, double-spaced; with a serial number for each reference on a new line, by indicating a DOI (if available). References should be numbered consecutively as they are cited rather than in alphabetical order. Text references should be indicated by Arabic numerals in square brackets.

You can find the DOI on the CrossRef website (

The references should enumerate all the authors who are given in the text as they are cited in the text rather in alphabetical order.

The references must necessarily include authors’ surname and initials, full name of book, place and year of publication for books; authors’ surname and initials, full title of article, name of journal, collection, year, issue, and complete page range for journals, collections.

According to the new rules that take into consideration the requirements of international citing systems, such as Web of Science and Scopus, the references should be included in the English-language part of an article and, accordingly, must be given not only in the original language, but also be necessarily transliterated to Latin script (Roman alphabet).

The Russian-language part of a reference should be directly followed by the English-language one in square brackets ( [...] ). The article DOI, if available, should be given at the end of the reference (behind the square bracket). At the very end of the English-language part of the reference, there should be the original language of the article in parentheses.

The foreign references remain unchanged.

All references to journal articles must include a DOI, a unique Digital Object Identifier of the article in the CrossRef system. Whether the article’s DOI is available on the website or should be checked. To obtain the DOI, the article’s title in English must be entered into a search box. In addition to DOI, the latest site automatically creates properly formatted references in English in the AMA citation style. The vast majority of foreign journal articles and many Russian-language articles, which have been published since 2013, are registered in the CrossRef system and have a unique DOI.

Rules for preparing Russian-language references for downloading into international citation indices.

1. References for journal.

All authors’ surnames and initials written in Latin and the article’s title in English should be given as in the original publication. This is followed by the name of a Russian-language journal in transliteration (spelling of a Russian word with Latin characters) in the BSI standard (automatic transliteration in the BSI standard is available on the page of by the imprint: year, volume, number, pages. The language of publication should be put in parentheses (In Russ.). The article’s DOI, if available, should be placed behind the square brackets at the end of a reference. 

You should not refer to journal articles without an English translation of their title.

References to theses, author’s abstracts, and proceedings published in various collections of conferences, congresses, etc. are not allowed.

2. All other references are transliterated to Latin script using the BSI standard, by maintaining the style of a Russian-language reference. The language of publication should be placed in parentheses (In Russ.). 

If the reference has been translated into English, its translation rather than transliteration should be indicated.

Both Russian and foreign references should be cited in Vancouver style in the AMA format (AMA style, 

Please, pay attention to the only proper format for citing doi: Example:

Variants with “doi:”, “”, etc. should not be used. Only a hyphen should be used in the body of a reference.

A point should not be put after doi and URL (http)!

References in the text of the article must be given with their numbers in square brackets in accordance with the reference list.

The authors mentioned in the article should be obligatorily given with initials, at the same time they must be indicated in the list of references. The names of foreign authors are given in the original transcription.

16. The Editorial Board reserves the right to shorten and correct articles.

17. The articles previously published or submitted to another journal may not be sent.

18. The articles that do not comply with the above requirements will be returned to the authors without consideration.

19. The procedure of reviewing the author's materials is as follows:

All articles submitted for publication in the journal will undergo a peer review process.

Reviewers handle the article as confidential material, by strictly observing the author’s right to confidentiality before the information contained in the article is published. Additional experts may be attracted to work by the reviewer only with the permission of the Editorial Board and also pursuant to the terms of a Confidentiality Agreement.

The comments of reviewers are sent to the author without specifying their names. A decision to publish (or reject) the article is made by the Editorial Board after receiving peer-reviews and an author’s responses.

In some cases the Editorial Board may send the article for further peer-review, including for statistical and methodological one.

For their expert evaluation, all materials submitted to the journal, which correspond to its topics, should be peer-reviewed. All reviewers are recognized experts on the topics of peer-reviewed materials and have publications on the subject of a peer-reviewed article over the past 3 years. Peer-reviews are kept in the Publishing House and the Editorial Office for 5 years.

The journal’s Editorial Board sends the copies of peer-reviews or a reasoned refusal to the authors of the submitted materials and also those of peer-reviews to the Ministry of Education and Science of the Russian Federation upon receipt of the relevant request to the Editorial Board.

The journal’s Editorial Board keeps assessing of the quality of peer-reviewing, by using the Russian version of the questionnaire Review Quality Instrument (Version 3.2), van Rooyen S., Black N., Godlee F.J Clin Epidemiol 1999; 52: 625—629.

20. Original articles should indicate the contribution of each author to which stage taken by him/her to prepare the article:

- Investigation conception and design

- Material collection and processing

- Statistical processing of data

- Text writing

- Editing


Authors I.I. Ivanov, P.P. Petrov, S.S. Sidorov

Investigation conception and design – I.I. Ivanov, S.S. Sidorov

Material collection and processing – P.P. Petrov

Statistical processing – P.P. Petrov

Text writing – S.S. Sidorov

Editing – I.I. Ivanov

21. Conflict of interests

When submitting their manuscript, authors are responsible for disclosing their financial and other interests of conflict, which are able to affect their work.

All essential conflicts of interest must be included in the manuscript (in the footnote on the title page).

If there are sponsors, authors must indicate their role in determining the design of investigation, in collecting, analyzing, and interpreting the data, and in deciding to publish the findings. The fact that the sources of financing have not participated in such actions should also be noted.

22. Informed consent

Do not publish

— any information that can identify a patient (by indicating his/her name, initials, case history numbers on photos, by making written descriptions and genealogies), except the cases that are of great scientific value and the patient (his parents or guardians) has given his/her (their) informed consent. Obtaining the consent should be reported in the article to be published.

23. Human and animal rights

If the article depicts human experiments, it should indicate whether they comply with the ethical standards of the Committee on Human Experiments (which is part of the institution in which the work has been done, or which is regional) or the 1975 Helsinki Declaration or its 2000 revision.

When describing animal experiments, the article should show whether the keeping and use of laboratory animals comply with the rules adopted at the institution, the recommendations of the National Research Council, and national laws.


Submission Preparation Checklist

As part of the submission process, authors are required to check off their submission's compliance with each of the following items, and submissions that do not adhere to these guidelines may be returned to the authors.

  • Absence of plagiarism.  The authors guarantee that this article has not been published in whole or in part, and is not under consideration or in the process of publication in another publication.

  • Correct manuscript format. Manuscript file format is Microsoft Word (has the extension *.doc, *.docx, *.rtf). The text adheres to the stylistic and bibliographic requirements outlined in the Author Guidelines.

  • Illustrations. Tables and figures were placed within the text of the manuscript and have their titles.

  • References. The list of references is formatted in accordance with the requirements. All the cited sources were checked for DOI.

  • Supplementary files. The authors have prepared for transfer to the editor

    • file containing full information about the authors (Surname, first name, place of work, e-mail address);
    • Graphic files (photos, satellite images, graphics, etc.).
    • The authors are ready to upload these files to the journal website in Step 3 during the manuscript submission process.
  • The authors confirm that:

    • all participants who have made a significant contribution to the study are presented as co-Authors;
    • those who did not participate in the study are not listed as co-Authors;
    • all co-Authors have seen and approved the final version of the work and agreed to submit it for publication.

Copyright Notice

Authors who publish with this journal agree to the following terms:

  1. Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work’s authorship and initial publication in this journal.
  2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal’s published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).


Privacy Statement

The editorial Board of the journal and the administration of the website of the journal do not transfer personal information in any way specified by the users when working with the website of the journal to third parties, except for those cases and to the extent specified in the terms of the copyright agreement.

The affiliation work and e-mail address of the authors of the manuscript accepted for publication will be published in the section "information about the authors" of the printed version of the journal and in the section "about the authors" on the page of the article on the website of the journal.

The phone number of the corresponding author will be known only to the editorial Board Secretariat and will only be used in cases of emergency.


Author Fees

This journal charges the following author fees.

Optional Open Access:

Price: 950.00 (USD)

OPTIONAL PAYMENT (this will NOT abrogate the Peer-Review decesion-based article selection).

Through Optional Open Access, authors of accepted papers are given the option of paying an open access publication charge to make their paper freely available online immediately via the journal website, meaning that readers will not need a journal subscription to view open access content. If an author does not choose to pay the open access publication charge, their paper will be published in the normal manner, and will not be made freely available online immediately.

Therefore there will be a mixture of non-open access and open access papers within each journal issue. Open access articles will be clearly indicated on the journal's online contents page. In order to view the non-open access content, a current subscription to the journal will be required. Online, print and combined subscription options will continue to be available to institutions. 

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