Vol 19, No 3 (2014)


Perinatal viral hepatitis C and performance capabilities for its therapy

Goryacheva L.G., Rogozina N.V., Greshnyakova V.A., Ivanova V.V.


The aim of the study: to establish the rate of the vertical transmission of HCV infection and justify the usefulness of the drug a-IFN2b (Viferon®) in children with perinatal infection with hepatitis C virus (HCV) at the early stages of the disease. There were examined 465 children aged 2.5 months to 3 years old (at the time of the enrollment in the study), born to mothers with HCV infection and the frequency of transmission from mother to child was established to be is 7.1% (33 cases). In 54.5% the genotype 1b was recorded, in 3% - 1a, and in 6.0 % - 2 genotype. Viferon® drug in doses of 3х10 6IU/m 2 was introduced to 17 infants aged from 3 to 12 months (duration of the course: 6 months in cases with 3, 2 genotype and 12 months - in patients with genotype 1). The efficacy of therapy was 58.8 % (RNA HCV (-) 10 cases. In prescription the drug to children under 6 months the efficacy was 62.5%, under 6-12 months - 44.4%. In the control group (16patients) spontaneous viral clearance was established to be in 18.7% of cases. The medication did not cause adverse effects and was well tolerated by children. In none out of the 17 children treated with the drug Viferon®, we have not reported adverse events (clinical symptoms, abnormalities in the hemogram and biochemical indices). The obtained data confirm the expediency of the early use of antiviral drug Viferon® in the treatment of children with perinatal HCV. Nо significant difference in the efficacy of therapy in different genotypes of the virus was identified. Virtually in all children (9 out of 10 children) responded to Viferon® therapy, there was noted Sustained Viral Response
Epidemiology and Infectious Diseases. 2014;19(3):4-8
pages 4-8 views

Hepatitis C in infection with recombinant strain RF2k/1b of the virus: clinical course and therapy

Nikolaeva L.I., Sapronov G.V., Kolotvin A.V., Samokhvalov E.I., Leybman E.A., Samokhodskaya L.M.


Intergenotype recombinant RF2k/1b of hepatitis C virus was firstly detected in 2002 in the Russian Federation. In our study patients, infected with this recombinant, had high indices of liver fibrosis and did not achieve a sustained viral response to standard double therapy with exception of one participant. There are discussed and proposed options for treatment and diagnosis of these patients.
Epidemiology and Infectious Diseases. 2014;19(3):9-15
pages 9-15 views

Features of the course of enteroviral infections with meningitis in adults during the epidemic season in 2013

Petrova I.S., Shyshov A.S., Bazarova M.V., Rusanova S.A., Burgasova O.A., Blank I.A., Leva V.G., Shurenkova E.N., Moskaleva E.V.


Solid sample of 135 patients aged of 15-17 years (54), 18-19 years (18), 20-59 years (63) with enteroviral infection and meningitis was examined. The peak of diseases was observed in July (43 persons), August (46), and September (22). The state of the moderate grade was in all patients. There were compared the frequency and severity of symptoms in individuals older than 20 years and adolescents aged 15-17 years. Initial pleocytosis in CSF - at day 1-3 (4-7th day in case of two-wave current) was less than 100 in 10, from 100 to 1000 in 40, more 1000 cells per 3 mm 3 - in 13 adult patients, including 17 - with a predominance of neutrophils (71 to 93% in cytosis of160-1584 cells per 3 mm 3). Enteroviral RNA in CSF was detected with the use of PCR in 132 patients, including 12 patients with cytosis of 3-28 cells in 3 mm 3. Maximum cytosis was 5952 cells per 3 mm 3 in patient of 17years old. In the peripheral blood of 28 patients there was noted leukocytosis of12,000-18,700 with a shift of the formula to the left. Most patients were discharged at the 9-13th day of the hospital stay. In 45,9% ofpatients the cases registered in Moscow were introduced from other regions and far abroad.
Epidemiology and Infectious Diseases. 2014;19(3):15-21
pages 15-21 views

Epidemiological evaluation of meningococcal infection in the Altai Krai

Shirokostup S.V., Safianova T.V., Krapivina E.A., Verevkina E.A., Nikishina K.A., Mezhevova V.E.


In the paper there are presented the main characteristics of the epidemic process of meningococcal infection in the Altai Krai in 2003-2012. The results of the study showed that the incidence was characterized by trend of the declining morbidity rate by 5 times from 3,34 ± 0,17 to 0,66 ± 0,17per 100 thousand of population, respectively (p <0,001) and cyclicity of 4years. In this case fatality rate decreased by 6.5 times from 0,54 ± 0,14 in 2003 to 0,08 ± 0,06per 100 thousand of population in 2012 (p <0,05). 85,7% of deaths occurred in persons aged under 17 years. Also there was performed ranking of administrative districts of the Krai on the levels of morbidity rate with the construction of cartograms.
Epidemiology and Infectious Diseases. 2014;19(3):22-25
pages 22-25 views

Study of prevalence of chlamydial infection and other STIs in youth in the Kursk Region on results of the regional dedicated programme

Anisimova N.S., Leonova I.Y., Bredikhina L.A., Knyaz'kova L.V., Starodubova N.I., Gushchin A.E.


Young people are at high risk for STIs. Along with this, for youth there is typical a low level of knowledge about STIs and prevention of infection. Therefore, an important element of prevention is the informing young people about STIs and their implications for reproductive health. The purpose of the study - to evaluate the prevalence of STIs among young people, who voluntarily turned in a perinatal center for examination after the outreach. A high prevalence of STIs among youth Kursk region was established as in the group with complaints and in cases without them. The first place in the structure of STI is occupied by chlamydial infection (77.5%). The creation and work of centers for the prevention of STIs among young people is a key mechanism in the prevention of disorders of the reproductive function in adolescents.
Epidemiology and Infectious Diseases. 2014;19(3):25-29
pages 25-29 views

Measles virus-specific IgG-antibodies level in umbilical cord blood according to the maternal age

Kostinov M.P., Shmitko A.D., Bocharova I.I., Cherdancev A.P., Savisko A.A., Polishchuk V.B.


Introduction. Mass vaccination and re-vaccination against measles as of children, as well additionally in adults, contributed to the significant decrease in morbidity rate. At the same time, outbreaks of measles in recent years, both in the World and in Russia, became more frequent, especially in the adult population. Aim: To determine the content of transplacental IgG-antibodies to measles virus in the umbilical cord blood, with taking into account of the age of the mother. Materials and methods. There was studied the cord blood of offsprings of 672 parturient women aged 16-43 years old, residing in Moscow and Moscow region, without a history of measles previously. The level of IgG-antibodies was determined by ELISA with the use of a standard set of reagents of the Firm "VECTOR-BEST", accordingly to instructions. Results. Protective (0.18 IU/ml) IgG-antibodies to measles virus in neonates were recorded in 79.9%. In females aged of 16-20 years protective antibodies were detected in 89,7%, 21-25 years - 80,8%, 26-30 years - 75% 31-35 - 75% 36-43 - 88,2% of cases. Average protective antibody level decreased according to the maternal age, respectively, and was the lowest (1,34 ± 0 22 IU/ml) in the group of women aged of 26 to 30 years and the high level was noted in 16-20 and 36-43 years old cases (2,18 ± 0,47 IU/ml and 2,73 ± 0,44 IU/ml). Conclusion. Women aged of 26-30 years are at risk for the development of measles infection, which is an indication for vaccination before pregnancy.
Epidemiology and Infectious Diseases. 2014;19(3):30-34
pages 30-34 views

Characteristics of antibiotic resistant strains of Vibrio cholerae carrying SXT type integrative conjugative elements

Podshivalova M.V., Kuzyutina Y.A., Zakharova I.B., Lopasteyskaya Y.A., Viktorov D.V.


In the paper there is presented a characteristics of antibiotic-resistant strains of Vibrio cholerae, isolated in the Volgograd region during the period of 1980-2000. There were studied cultural and morphological properties of the isolates, their biochemical activity, resistance to antibiotics of different classes, there was performed the detection of virulence genes and sequences of transmissible SXT-element. There was demonstrated the presence of different types of SXT in the content of the genome of the examined strains - SXT MO10 element with cluster of the antibiotic resistance gene sulII-strB-dfr18, SXT ET element carrying the sequences sulII dfrA1, and not having a resistance gene to aminoglycosides strB, and SXT S element with deleted cluster of antibiotic resistance genes.
Epidemiology and Infectious Diseases. 2014;19(3):34-39
pages 34-39 views

Morgellons disease vs dermatozoic delusion: unexpected psychodermatological problem for parasitologists and infectious disease doctors. Personal observations and review of the literature

Bronshtein A.M., Malishev N.A., Kochergin N.G., Davydova I.V.


The term "Morgellons disease" has been introduced by patients, who pointed to the emerging from the skin threads, worms, insects, etc. For the study and dissemination of information on Morgellons disease funds have been established. Since 2002 through the Internet and the media the information about Morgellons disease in the United States and Western Europe began to spread. Since 2009 Morgellons disease was started to be detected in Russia, Ukraine and Belarus. The term "Morgellons disease" is used by some doctors in medical certificates for the purpose of information for other doctors in the free, not encrypted form about the presence of the mental disorder in a patient. Morgellons disease is one of the manifestations of dermatozoic delusion. Patients with Morgellons disease ask parasitologists and infectious disease doctors for medical help, write complaints to the overhead organizations, and flatly refuse to be observed by the psychiatrists. Parasitologists and infectious disease doctors should treat patients who claim that they have Morgellons disease, as patients with the dermatozoic delusion, and must not use the diagnosis of Morgellons disease in their practice.
Epidemiology and Infectious Diseases. 2014;19(3):40-50
pages 40-50 views

New generation of policlonal enteroviral diagnostic sera

Kozlov V.G.


The human non-polio enteroviruses (NPEV) are ubiquitous viruses found worldwide. NPEV are etiological agents of various diseases. Traditional method of identification NPEV is the detection of serotype with the use of neutralizing serotype-specific sera. Limiting amount ofproduced horse enteroviruses reference serum is not available for practical diagnostic laboratories. In the paper there are presented the results of the improvement of methods for delivery of diagnostic enteroviral rabbit sera for the reaction of neutralization in amounts sufficient to national health care.
Epidemiology and Infectious Diseases. 2014;19(3):51-56
pages 51-56 views

Book review A.M. Bronstein "Tropical diseases and medicine diseases travelers"

Nikiforov V.V.
Epidemiology and Infectious Diseases. 2014;19(3):57-57
pages 57-57 views

Scientific Conference of the Problem Commission “Arboviruses and other zoonoses viruses: Topical issues of the study of West Nile fever, dengue fever and other tropical imported arboviral infections in the Russian Federation”

Butenko A.M.


In the article there is presented a brief overview concerning proceedings of RAMS Problem Commission "Arboviruses and other zoonoses viruses" on the theme: "Actual issues of studying of West Nile fever, dengue fever and other tropical imported arboviral infections in the Russian Federation", which was held in Federal State Budgetary Institution "D. I. Ivanovsky Institute of Virology (Russian Federation, Moscow) on 16th of March, 2014.
Epidemiology and Infectious Diseases. 2014;19(3):58-61
pages 58-61 views

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies