Epidemiological and clinical characteristics of cases and detection of pathogens’ markers of tick-borne infections in the Tomsk region

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BACKGROUND: Among the spectrum of the tick-borne infections, Lyme borreliosis and tick-borne encephalitis are most often recorded in the Tomsk region, however it is obviously that possible range of the pathogens is not limited to these ones.

AIM: To make epidemiological and clinical characteristics of cases and detect frequencies of pathogen’s markers of tick-borne infections among adult patients applying serological and molecular genetic techniques in the Tomsk region during 2020–2023.

METHODS: A single-center prospective sample study was conducted applying a comprehensive approach in peripheral blood specimens obtained from 197 patients with suspected tick-borne infections hospitalized during 2020–2023. To verify the diagnoses of tick-borne encephalitis or Lyme borreliosis, specific immunoglobulins of classes M and G to the antigens of virus of tick-borne encephalitis and Borrelia burgdorferi s.l. were determined in paired blood serum samples applying enzyme-linked immunosorbent assay. Additionally, the polymerase chain reaction was used to detect genetic markers of virus of tick-borne encephalitis, B. burgdorferi s.l., B. miyamotoi, Rickettsia spp., Coxiella burnetii, and Francisella tularensis. Epidemiological surveillance data of incidence rates of tick-borne infections obtained from official reports were analyzed as well. MS Office Excel 2010 software was used to calculate frequency morbidity measures.

RESULTS: We verified the final diagnosis of tick-borne encephalitis in 52 (26.4%) patients, Lyme borreliosis in 116 (58.9%) patients, co-infection of tick-borne encephalitis and Lyme borreliosis 15 (7.6%) patients, hard tick relapsing fever caused by B. miyamotoi in 8 (4.1%) patients, coinfection of Q fever caused by C. burnetii with tick-borne encephalitis or Lyme borreliosis in 4 (2.0%) patients, and coinfection of tularemia with tick-borne encephalitis or Lyme borreliosis in 2 (1.0%) cases. We identified markers of tick-borne encephalitis and Lyme borreliosis pathogens by polymerase chain reaction in 3.6% and 4.1% of the patients. Most number of individuals with tick bites, and the highest incidence rates of Lyme borreliosis and tick-borne encephalitis were recorded in the suburbs of Tomsk. The age groups of 40–59 years, and elderly people 60 years and older were predominated among the patients.

CONCLUSIONS: It was found out that, in addition to Lyme borreliosis and tick-borne encephalitis, there were such tick-borne infections as tick relapsing fever, Q fever, and tularemia in the Tomsk region in the 2020–2023 period.

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作者简介

Ekaterina Ilyinskikh

Siberian State Medical University

编辑信件的主要联系方式.
Email: infconf2009@mail.ru
ORCID iD: 0000-0001-7646-6905
SPIN 代码: 5245-5958
Scopus 作者 ID: 6602611268
Researcher ID: P-1653-2016

MD, Dr. Sci. (Medicine), Assistant Professor

俄罗斯联邦, 2 Moskovsky trakt, 634050 Tomsk

Evgeny Bondarenko

JSC “Vector-Best”

Email: ebond111@yandex.ru
ORCID iD: 0000-0002-4699-9548
SPIN 代码: 2302-9058

MD, Cand. Sci. (Medicine)

俄罗斯联邦, Novosibirsk

Olga Voronkova

Siberian State Medical University

Email: Voronkova-ov@yandex.ru
ORCID iD: 0000-0001-9478-3429
SPIN 代码: 8005-8110
Scopus 作者 ID: 12773202300
Researcher ID: O-7952-2016

MD, Dr. Sci. (Medicine), Assistant Professor

俄罗斯联邦, 2 Moskovsky trakt, 634050 Tomsk

Maria Karpova

Siberian State Medical University

Email: mrkarpova@mail.ru
ORCID iD: 0000-0002-7109-9955
SPIN 代码: 6935-7447
Scopus 作者 ID: 7006372355
Researcher ID: M-9333-2016

MD, Dr. Sci. (Medicine), Professor

俄罗斯联邦, 2 Moskovsky trakt, 634050 Tomsk

Evgenia Filatova

Siberian State Medical University

Email: synamber@mail.ru
ORCID iD: 0000-0001-9951-8632
SPIN 代码: 8094-3417
Researcher ID: AEQ-2635-2022

MD

俄罗斯联邦, 2 Moskovsky trakt, 634050 Tomsk

Alina Reshetova

Siberian State Medical University, Tomsk, Russia

Email: wind_of_change95@mail.ru
ORCID iD: 0000-0001-5195-3897
SPIN 代码: 2690-1166
Researcher ID: ACK-7745-2022

MD

俄罗斯联邦, 2, Moskovsky trakt, Tomsk, 634050, Russia

Tatyana Poltoratskaya

Center for Hygiene and Epidemiology in the Tomsk Region

Email: ptn077@bk.ru
ORCID iD: 0000-0002-1992-4970
SPIN 代码: 4478-0309

MD, Cand. Sci. (Medicine)

俄罗斯联邦, Tomsk

Natalya Sizova

Center for Hygiene and Epidemiology in the Tomsk Region

Email: parsesto@cge.tom.ru
ORCID iD: 0009-0004-2528-1125

MD

俄罗斯联邦, Tomsk

Olga Koryakova

Center for Hygiene and Epidemiology in the Tomsk Region

Email: koryakova.o.s@cge.tom.ru
ORCID iD: 0009-0004-4092-589X

MD

俄罗斯联邦, Tomsk

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