Vol 16, No 4 (2011)


Treatment personalization for patients with streptococcal quinsy on the basis of determination of the activity of metabolic enzyme systems

Kravchenko I.E., Briko N.I., Fazylov V.K., Kravchenko I.E., Briko N.I., Fazylov V.K.


The metabolic enzyme systems of acetylation and microsomal oxidation were studied in patients with streptococcal quinsy. A relationship was found between the clinical forms of the disease and the specific features of biochemical processes in the organism. There was evidence that the pyrimidine drug ximedon should be incorporated into combination therapy for quinsy to regulate metabolic processes, by taking into account the phenotypes of acetylation and oxidation and the forms of the disease.
Epidemiology and Infectious Diseases. 2011;16(4):4-7
pages 4-7 views

Role of nonspecific infection in the development of acute and chronic inflammatory diseases of the nervous system

Bondarenko V.M., Ryabichenko E.V., Bondarenko V.M., Ryabichenko E.V.


The paper presents an update on the susceptibility of the central nervous system (CNS) to inflammation in response to injury, infection, or disease. CNS resident cells generate inflammatory mediators, including proinflammatory cytokines, prostaglandins, free radicals, and a complement, which induce chemokines and adhesion molecules, recruit immune cells, and activate glial cells. Inflammation and inflammatory mediators, in turn, cause neurodegeneration and are thus involved in the pathogenesis of acute and chronic mental and CNS diseases. Information is given on the expression of inflammatory mediators, on the mechanisms that regulate inflammation, and on the CNS in brain injury, epilepsy, multiple sclerosis, Alzheimer's disease and Parkinson's disease. The integrative action of inflammatory mediators in combination with processes of ageing burdened with heredity and poor environmental factors plays an important role in the development and prolongation of chronic neurodegeneration and should be kept in mind during therapy for CNS diseases. Emphasis is placed on effective approaches to treating acute neurological impairments (stroke, injury) when the early use of an IL-1 receptor antagonist is of importance and on chronic inflammatory neurodegenerative processes when long-term anti-inflammatory therapy reducing the rate of relapses of the disease and its progression is indicated.
Epidemiology and Infectious Diseases. 2011;16(4):8-14
pages 8-14 views

The improvement of epidemiological surveillance and control of nosocomial pneumonias associated with mechanical ventilation

Golubkova A.A., Sisin E.I., Bogushevich Y.A., Bastrykov A.A., Orlovskaya E.M., Soboleva L.I., Balagutdinova S.A., Golubkova A.A., Sisin E.I., Bogushevich Y.A., Bastrykov A.A., Orlovskaya E.M., Soboleva L.I., Balagutdinova S.A.


An epidemiological analysis of the prevalence of nosocomial pneumonias associated with mechanical ventilation (NPmv) in the intensive care unit (ICU) of a multidisciplinary hospital shows the informative value of various sources, including those based on current technologies. The authors have comparatively evaluated the impact of 6 disinfectological technologies successively used in the ICU for therapy for in-hospital spread of P. aeruginosae strains on the incidence of NPmv.
Epidemiology and Infectious Diseases. 2011;16(4):14-18
pages 14-18 views

Development of a test system for the serodiagnosis of yersiniases by an immunoblot test

Kokorina G.I., Burgasova O.A., Aniskina G.P., Yushchuk N.D., Tseneva G.Y., Kokorina G.I., Burgasova O.A., Aniskina G.P., Yushchuk N.D., Tseneva G.Y.


The pseudotuberculosis pathogen Y. pseudotuberculosis and the enteric yersiniasis pathogen Y. enterocolitica may cause both acute and chronic diseases. Widely practically used diagnostic methods are effective in the acute period of the diseases whereas diagnosis verification in the protracted and chronic course of yersiniases remains an urgent problem. For solution of this problem, the authors have developed a cost-effective test system for the serodiagnosis of yersiniases by an immunoblot test, by applying the recombinant proteins of recombinant Yersinia outer membrane proteins, such as YopH (51 kD), YopM (44 kD), YopD (35 kD), and YopE (23 kD). As compared to indirect hemagglutination test, agglutination test, and enzyme immunoassay, the immunoblot test has a high sensitivity and a high specificity and may be promising mainly in diagnosing the chronic forms of Yersinia infection.
Epidemiology and Infectious Diseases. 2011;16(4):18-23
pages 18-23 views

Regularities of changes in laboratory parameters in patients with A/H1N1 influenza pneumonia

Romanova E.N., Serebryakova O.M., Govorin A.V., Filev A.P., Romanova E.N., Serebryakova O.M., Govorin A.V., Filev A.P.


The medical records of 97 patients with A/H1N1 influenza pneumonia were analyzed. The important feature of the disease is a high risk of fatal outcomes, the direct cause of which is acute respiratory distress syndrome (ARDS). The most significant abnormalities of laboratory values were noted in this category of patients. In ARDS, leukopenia or normocytosis changed to leukocytosis, which is attributed to massive bacterial infection. These patients were also recorded to have immunodeficiency-induced lymphopenia and disseminated intravascular coagulation-induced thrombocytopenia. The marked elevation of transaminases mainly due to asparagine transaminase and the increase of creatine phosphokinase suggest that the most severe category of patients has rhabdomyolysis. Characteristic of this was a reactive rise of amylase. In ARDS, diminished renal functional capacity reflected the higher blood levels of creatinine and urea.
Epidemiology and Infectious Diseases. 2011;16(4):23-27
pages 23-27 views

Role of highly avid antitoxic antibodies in the estimation of insusceptibility to diphtheria infection

Kraeva L.A., Tseneva G.Y., Nikolaeva A.M., Alekseeva E.A., Krayeva L.A., Tseneva G.Y., Nikolayeva A.M., Alekseyeva E.A.


A procedure was developed to determine the avidity of antitoxic antidiphtheria antibodies, by using the enzyme immunoassay. It was shown that both total antibodies and their avidity might be estimated in one test. A study of sera from healthy vaccinees could define differences in the time course of changes in the accumulation and loss of both total and highly avid antitoxic antidiphtheria antibodies. Maturation of highly avid antibodies took place more slowly than the total number of antibodies increased whereas loss of highly avid antibodies occurred much more quickly than the total count of antibodies decreased. Five years following regular revaccination, the antibody avidity index achieved its minimal (critical) level while the content of antitoxic antibodies was reduced to critical values (0.01 IU/ml) at 7-8 years after revaccination. Risk groups were identified among the examinees. These included subjects aged over 50 years, medical workers, industrial workers, particularly those engaged in hazardous occupations, subjects with chronic somatic and infectious diseases, and those vaccinated against diphtheria more than 5 years ago.
Epidemiology and Infectious Diseases. 2011;16(4):27-31
pages 27-31 views

Clinical and immunological rationale for imunofan use in combination therapy for hemorrhagic fever with renal syndrome

Tutel'yan A.V., Khasanova G.M., Tutelyan A.V., Khasanova G.M.


The study was undertaken to estimate phagocytic functional capacity in patients with hemorrhagic fever with renal syndrome (HFRS) in different periods of the disease and its association with trace element status. One hundred and forty-eight patients with HFRS were examined. Phagocytic functional activity was measured by luminal-dependent chemiluminescence using an X‹M-003 chemiluminometer; the blood concentrations of zinc, copper, selenium, aluminum, lead, mercury, cadmium, and strontium were estimated in parallel by inductively-coupled plasma mass spectrometry (ICP-MS; Elan-9000, Perkin Elmer, USA). A relationship was found between phagocytic functional capacity and trace element status in the dynamics of HFRS development.
Epidemiology and Infectious Diseases. 2011;16(4):32-36
pages 32-36 views

Gender features of erysipelas

Ratnikova L.I., Dubovikova T.A., Ship S.A., Zhamburchinova A.N., Ratnikova L.I., Dubovikova T.A., Ship S.A., Zhamburchinova A.N.


The paper gives the results of an investigation of the role of reproductive functional state in the pathogenesis of erysipelas in men and women. There are gender-related differences in the clinical course of the disease.
Epidemiology and Infectious Diseases. 2011;16(4):36-40
pages 36-40 views

Study of regularities of an immune response in children with Epstein-Barr virus infection

Astrakhantseva I.V., Kuvshinov M.V., Krasnov V.V., Ulanova T.I., Obryadina A.P., Volova L.Y., Astrakhantseva I.V., Kuvshinov M.V., Krasnov V.V., Ulanova T.I., Obryadina A.P., Volova L.Y.


Persistent infections have now become an increasingly urgent problem. One of the priorities in this area is to study diseases caused by Epstein-Barr virus (EBV) belonging to the family of herpes viruses type IV. The purpose of this investigation was to study the mechanisms of development of an immune response to EBV infections in relation to the patient's age. Serum samples from in 411 children aged 5 days to 17 years, 503 donors, and 49 parturients were tested for the following markers of EBV infection: anti-VCA-IgM, anti-VCA-IgG, anti-EA-IgG, anti-NA-IgG. The sera containing anti-VCA-IgG were further examined for the avidity of specific antibodies. The present investigation has shown that the EBV infection rates at 3 years of life do not differ significantly from those in adult donors and it was more than 95%. At the same time, about 40% of the children become infected during the first year of life. There is a tendency for higher rates of primary infection in pubertal children. IgG-EA as a marker of active EBV infection is most characteristic of infants aged 1 to 2 years and children aged 14 to 17 years. Anti-VCA-IgM is not a valid marker of primary infection. Comprehensive determination of a serological profile is required for the valid diagnosis of the stage of EBV infection.
Epidemiology and Infectious Diseases. 2011;16(4):40-44
pages 40-44 views

Study of a trend in the epidemic process of West Nile fever in the Volgograd Region over the period 2000-2009

Manankov V.V., Alekseev V.V., Smelyanskiy V.P., Pashanina T.P., Pogasiy N.I., Putintseva E.V., Britanova A.L., Antonov V.A., Alekseeva V.V., Tkachenko G.A., Savchenko S.T., Rusakova N.V., Frolova G.I., Frolov A.Y., Ioannidi E.A., Bozhko V.G., Popov S.F., Manankov V.V., Alekseyev V.V., Smelyansky V.P., Pashanina T.T., Pogasiy N.I., Putintseva E.V., Britanova A.L., Antonov V.A., Alekseyeva V.V., Tkachenko G.A., Savchenko S.T., Rusakova N.V., Frolova G.I., Frolov A.Y., Ioannidi E.A., Bozhko V.G., Popov S.F.


Over the period 1999 to 2009, in the Volgograd Region there were 526 notified cases of West Nile fever (WNF), of them 46 (8.7%) patients died. The bulk of the patients were registered during its epidemic outbreak in 1999. The paper shows a trend in human morbidity and its association with the infection rates of mosquito carriers. It defines a role of birds, crows (Corvidae) in particular, in the active prevalence of WNF in the Volgograd Region. The data given in the Volgograd Region led to the conclusion that there was a sustained secondary natural focus of WNF with an epicenter being in the Volga-Aktyubinsk floodplain and with the involvement of Volgograd and Volzhsky into the epidemic process.
Epidemiology and Infectious Diseases. 2011;16(4):45-49
pages 45-49 views

Cyclic causality of cholera epidemic manifestations in India

Arutyunov Y.I., Arutyunov Y.I.


Analysis of the incidence of cholera in India suggests the cyclicity of its manifestations, which is associated with solar activity. The peak numbers of patients have been found to occur an average every 3.1, 5.2, and 10.9 years, which are timed in a phase of the minimum solar activity to the year of its previous minimum and in a phase of its maximum to -2, +1, +2, and +4 years of the maximum.
Epidemiology and Infectious Diseases. 2011;16(4):49-52
pages 49-52 views

Acute enteric schistosomiasis in a Russian tourist after travel to Tanzania

Sayfullin M.A., Bronshteyn A.M., Malyshev N.A., Saifullin M.A., Bronshtein A.M., Malyshev N.A.


The paper describes a case of acute schistosomiasis caused by S. mansoni in a Moscow tourist who has visited Tanzania. It is noted that it is objectively difficult to parasitologically confirm this infestation in its acute stage. The problems of the accessibility of information on the prevention of tropical diseases in tourists are discussed.
Epidemiology and Infectious Diseases. 2011;16(4):53-56
pages 53-56 views

A case of pseudocowpox

Nafeev A.A., Magomedov M.A., Struchin V.E., Kadoeva V.B., Timofeeva S.P., Nafeyev A.A., Magomedov M.A., Struchin V.E., Kadoyeva V.B., Timofeyeva S.P.


Pseudocowpox (milker's nodules) is s zoonotic virus infection in cows, less frequently sheep and goats, which is characterized by varioliform lesion on the teats, may be transmitted to man at hand or even mechanical milking, and now occurs rarely in human beings. Cows are ill with two pox diseases caused by various viruses. One of them is pseudocowpox (vaccinia) virus that gives rise to persistent immunity in man against human pox; the other is its relative virus that causes cowpox called paravaccinia that can is transmitted to man, by developing a short-term immunity (not more than several months). The latter is known as milker's or dairymaid's disease. Cowpox can spread from animals to human beings with a weakened (or none) immunity against smallpox. Sporadic cases are generally notified. Only sick animals are a source of cowpox infection for man. In 2010 in the Ulyanovsk Region there was a notified case of cowpox in a female patient who complained about edema in both hands, fusing red papillomas that spread to the elbows and forearms, and red spots on the left face, and herpes-like lip pimples. The patient said that she had milked cows that had warts (nodules) and cuts on the udders.
Epidemiology and Infectious Diseases. 2011;16(4):56-58
pages 56-58 views
pages 58-59 views
pages 59-60 views

In memory of Mikhail Vasilyevich Skachkov

- -.
Epidemiology and Infectious Diseases. 2011;16(4):61-61
pages 61-61 views

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies