Epidemiology and Infectious DiseasesEpidemiology and Infectious Diseases1560-95292411-3026Eco-Vector4056110.17816/EID40561Regularities of changes in laboratory parameters in patients with A/H1N1 influenza pneumoniaRomanovaElena Nikolaevnatpkmacadem_chita@mail.ruSerebryakovaOl'ga Mikhaylovnas.olga77@mail.ruGovorinAnatoliy Vasil'evich-FilevAndrey Petrovich-RomanovaE NChita State Medical Academy, Ministry of Health and Social Development-SerebryakovaO MTown Clinical Hospital One-GovorinA VChita State Medical Academy, Ministry of Health and Social Development-FilevA PChita State Medical Academy, Ministry of Health and Social Development-Chita State Medical Academy, Ministry of Health and Social DevelopmentTown Clinical Hospital One15082011164232723072020Copyright © 2011, Eco-vector2011The medical records of 97 patients with A/H1N1 influenza pneumonia were analyzed. The important feature of the disease is a high risk of fatal outcomes, the direct cause of which is acute respiratory distress syndrome (ARDS). The most significant abnormalities of laboratory values were noted in this category of patients. In ARDS, leukopenia or normocytosis changed to leukocytosis, which is attributed to massive bacterial infection. These patients were also recorded to have immunodeficiency-induced lymphopenia and disseminated intravascular coagulation-induced thrombocytopenia. The marked elevation of transaminases mainly due to asparagine transaminase and the increase of creatine phosphokinase suggest that the most severe category of patients has rhabdomyolysis. Characteristic of this was a reactive rise of amylase. In ARDS, diminished renal functional capacity reflected the higher blood levels of creatinine and urea.community-acquired pneumoniaA/H1N1 influenzaacute lung injuryacute respiratory distress syndromeвнебольничная пневмониягрипп A/H1N1острое повреждение легкихострый респираторный дистресс-синдром[Гельфанд Б. Р., Кассиль В. Л. Острый респираторный дистресс-синдром. - М., 2007.][Кассиль В. Л., Золотокрылина Е. С. Острый респираторный дистресс-синдром. - М., 2003.][Лапа С. А., Родина Н. Н., Скрипченко Е. М. и др. Эпидемиологическая ситуация по гриппу A/H1N1 в Забайкальском крае в 2009-2010 годах // Материалы Всероссийской науч.-практ. конф. с международным участием "Итоги эпидемии гриппа A/H1N1". Чита, 26-27 окт. 2010. - Чита, 2010. - С. 154-157.][Внебольничная пневмония у взрослых: Практ. рекомендации по диагностике, лечению и профилактике / Чучалин А. Г., Синопальниов А. И., Страчунский Л. С. и др. - М., 2009.][Чучалин А. Г. Грипп: уроки пандемии // Пульмонология. - 2010. - Прил.: Грипп A/H1N1: уроки пандемии. - С. 3-8.][Rise T. W., Wheeler A. P., Bernard G. R. et al. Comparison of SpO2/FiO2 ratio in patients with acute lung injury or ARDS // Chest. - 2007. - Vol. 132. - P. 410-417.]