Email this article Dynamics of Streptococcus pneumoniae serotype structure in children for the period 2016-2022
- Authors: Protasova I.N.1, Feldblium I.V.2, Bakhareva N.V.3, Zinovieva L.V.4, Sidorenko S.V.5
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Affiliations:
- Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University
- Perm State Medical University named after Academician E.A. Wagner
- Krasnoyarsk Regional Center for Prevention and Control of AIDS
- Krasnoyarsk City Children's Hospital No. 8,
- Children's Scientific and Clinical Center for Infectious Diseases of the Federal Medical and Biological Agency
- Section: ORIGINAL STUDIES
- URL: https://rjeid.com/1560-9529/article/view/627518
- DOI: https://doi.org/10.17816/EID627518
- ID: 627518
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Abstract
Background. The need for microbiological monitoring of the distribution of pneumococcal serotypes is associated with changes that occur during routine immunization of children with pneumococcal vaccines.
Aim. To characterize the changes in the serotype structure of S. pneumoniae obtained from healthy preschool children from 2016 to 2022.
Materials and methods. Nasopharyngeal isolates of pneumococcus (n=265) were obtained from 1250 healthy children under 6 years of age attending kindergartens. Serotype structure of S. pneumoniae was performed using PCR.
Results. During 2016-2018, the prevalence of pneumococcal carriage was decreased from 27.3% to 17.3%, and by 2022 it was increased again to 25.6%. At the same time, the correspondence of S. pneumoniae serotypes to the antigenic composition of the 13-valent pneumococcal vaccine was decreased from 48.8% to 9.4%, and to the composition of the 20-valent vaccine – from 75.6% to 39.1%. The proportion of “non-vaccine” types of pneumococcus, accordingly, increased from 22% in 2016 to 61% in 2022. Among the “non-vaccine” serotypes/groups, 15AF, 6CD, 23A and 35F/47F were predominated, and new variants were also discovered: 23B and 35B. The serotypes included in the 13-valent conjugate vaccine were detected, as a rule, among unvaccinated children and were represented by variants 19F, 6A and 6B, 23F. Throughout the observation period, pneumococci of serotypes/groups 15BC, 11AD and 10A were detected with high frequency.
Conclusions. During 2016-2022, due to the elimination of a significant part of the “vaccine” S. pneumoniae serotypes, there was a significant decrease in the compliance of circulating pathogen variants with the antigenic composition of the used conjugate vaccines. At the same time, new types that are detected with high frequency are not included in existing pneumococcal vaccines which necessitates the creation of new immunobiological drugs.
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ADDITIONAL INFORMATION
Funding source. The research was carried out as part of a multicenter international prospective epidemiological study of the characteristics of pneumococcal infection “SAPIENS” (2016-2018 and 2020-2022), sponsored by the Rostropovich Vishnevskaya foundation “For the health of children.”
Competing interests. The authors declare that they have no competing interests.
Authors’ contribution. All authors made a substantial contribution to the conception of the work, acquisition, analysis, interpretation of data for the work, drafting and revising the work, final approval of the version to be published and agree to be accountable for all aspects of the work. I.N. Protasova –microbiological research, data analysis, writing the text; I.V. Feldblium – concept of the study, editing; N.V. Bakhareva – organizing the collection material, data analysis, editing; L.V. Zinovieva – data collection; S.V. Sidorenko – study concept and design.
About the authors
Irina Nikolaevna Protasova
Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University
Author for correspondence.
Email: ovsyanka802@gmail.com
ORCID iD: 0000-0001-6521-8615
SPIN-code: 4599-4410
Scopus Author ID: 57194856372
ResearcherId: M-2754-2014
MD, Associate Professor of Microbiology Department named after Ass. Prof. B.M. Zelmanovich
Russian Federation, 660022, Russian Federation, Krasnoyarsk, Partizana Zheleznyaka street, 1Irina Viktorovna Feldblium
Perm State Medical University named after Academician E.A. Wagner
Email: irinablum@mail.ru
ORCID iD: 0000-0003-4398-5703
SPIN-code: 3394-9879
MD, Professor, Head of Epidemiology and Hygiene Department
Russian Federation, 614990, Russian federation, Perm, Petropavlovskaya str., 26Natalia Vasilevna Bakhareva
Krasnoyarsk Regional Center for Prevention and Control of AIDS
Email: bakhareva@kraszdrav.ru
ORCID iD: 0000-0003-2868-1509
Epidemiologist; Сhief freelance epidemiologist, Ministry of Health of the Krasnoyarsk Territory
Russian Federation, 660049, Russian Federation, Krasnoyarsk, Karl Marks str., 45, building 1Ludmila Vasilevna Zinovieva
Krasnoyarsk City Children's Hospital No. 8,
Email: Lzinovieva@gdb8.ru
Deputy Chief Physician
Russian Federation, Krasnoyarsk, Russian federation, Urvantseva str., 30ASergey Vladimirovich Sidorenko
Children's Scientific and Clinical Center for Infectious Diseases of the Federal Medical and Biological Agency
Email: sidorserg@yandex.ru
ORCID iD: 0000-0003-3550-7875
SPIN-code: 7738-7060
Scopus Author ID: 7102484509
ResearcherId: E-5870-2011
MD, Professor, Head of the Department of Molecular Microbiology and Medical Epidemiology
Russian Federation, 197022, Russian Federation, St. Petersburg, Professor Popov str., 9References
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