Antiretroviral therapy and its impact on lipid metabolic parameters
- Authors: Kanestri V.G.1, Kravchenko AV1, Deulina MO1, Kanestri VG2, Kravchenko AV2, Deulina MO2
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Affiliations:
- Federal Research and Methodological Center for AIDS Prevention and Control, Moscow
- Issue: Vol 16, No 1 (2011)
- Pages: 44-48
- Section: Articles
- URL: https://rjeid.com/1560-9529/article/view/40578
- DOI: https://doi.org/10.17816/EID40578
- ID: 40578
Cite item
Full Text
Abstract
All the test antiretroviral drugs affect lipid profile just during early treatment. The most common metabolic disturbance was elevated triglycerides when ritonavir-boosted protease inhibitors, lopinavir in particular, were administered. However, in this drug group, AI was minimal (1.29) due to the significantly higher concentration of HDL. Non-nucleotide reverse HIV transcriptase generally failed to affect the level of TC, TG, and LDL, but reduced HDL concentrations, which resulted in a pronounced increase in AI (4.4) following 72 weeks of treatment. The unboosted protease inhibitors atazanavir and nelfinavir were the safest agents in terms of metabolic disturbances. None of the patients developed lipodystrophy 72 weeks after therapy.
Thus, it is expedient to determine lipid metabolic parameters and body build before start of therapy and at least every 6 months in all HIV-infected patients in order to prevent lipodystrophy and/or cardiovascular diseases.
Keywords
About the authors
Veronika Gennadievna Kanestri
Email: kanestri@yandex.ru
A V Kravchenko
M O Deulina
V G Kanestri
Federal Research and Methodological Center for AIDS Prevention and Control, MoscowFederal Research and Methodological Center for AIDS Prevention and Control, Moscow
A V Kravchenko
Federal Research and Methodological Center for AIDS Prevention and Control, MoscowFederal Research and Methodological Center for AIDS Prevention and Control, Moscow
M O Deulina
Federal Research and Methodological Center for AIDS Prevention and Control, MoscowFederal Research and Methodological Center for AIDS Prevention and Control, Moscow
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