Choice of nucleoside inhibitors in antiretroviral therapy regimens for HIV-infected patients treated for chronic hepatitis C
- Authors: Gankina NY.1, Kravchenko AV2, Kuimova UA3, Kanestri VG2
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Affiliations:
- Krasnoyarsk Territorial Center for Prevention and Control of AIDS and Infectious Diseases
- Federal Research and Methodological Center for AIDS Prevention and Control, Moscow
- Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare, Moscow
- Issue: Vol 15, No 3 (2010)
- Pages: 42-46
- Section: Articles
- URL: https://rjeid.com/1560-9529/article/view/40482
- DOI: https://doi.org/10.17816/EID40482
- ID: 40482
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Full Text
Abstract
Among all the patients, rapid and complete early virologic responses (rEVR and cEVR) were obtained in 52 and 79% of cases, respectively. When phosphaside was used in the ART regimens, the rates of rEVR and cEVR development were significantly higher (95.8 and 53.3% of cases, respectively). The phosphaside-treated patients with hepatitis C virus (HCV) genotype 1 also had a high cEVR rate. The absolute majority of patients with HCV genotype 3 showed cEVR irrespective of the ART regimen. Following 12-week treatment for CHC, 83.3-95.5% had a reduction in alanine aminotransferase levels to the values observed in healthy individuals, which was also indicative of the efficiency of treatment. In the HIV infected patients treated for CHC, the use of phosphaside, stavudine, or abacavir was safe in terms of hematological complications. In the patients receiving phosphaside, the reduction in hemoglobin levels was more considerable. Evolving hematological disorders required no changes in the ART regimen or reductions in the dose of pegylated interferon or ribavirin.
About the authors
N Yu Gankina
Krasnoyarsk Territorial Center for Prevention and Control of AIDS and Infectious DiseasesKrasnoyarsk Territorial Center for Prevention and Control of AIDS and Infectious Diseases
A V Kravchenko
Federal Research and Methodological Center for AIDS Prevention and Control, Moscow
Email: kravtchenko@hivrussia.net
Federal Research and Methodological Center for AIDS Prevention and Control, Moscow
U A Kuimova
Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare, MoscowCentral Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare, Moscow
V G Kanestri
Federal Research and Methodological Center for AIDS Prevention and Control, MoscowFederal Research and Methodological Center for AIDS Prevention and Control, Moscow
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