Surgical Hand Antisepsis in the Soviet Union: Stages of Development, Technical Capabilities, and Technologies
- Authors: Sisin E.I.1,2, Golubkova A.A.3,4, Kozlova I.I.1,2, Ezhova O.A.5,6, Berezikova K.I.1, Gorbunova I.E.1
-
Affiliations:
- Khanty-Mansiysk State Medical Academy
- Center for Hygiene and Epidemiology in the Khanty-Mansiysk Autonomous Okrug ― Yugra
- Central Research Institute of Epidemiology
- Russian Medical Academy of Continuous Professional Education
- Department of Healthcare of Khanty-Mansiysk Autonomous Okrug ― Yugra
- Nyagan City Clinic
- Issue: Vol 29, No 6 (2024)
- Pages: 455-466
- Section: Historical Articles
- Submitted: 09.02.2025
- Accepted: 28.02.2025
- Published: 21.05.2025
- URL: https://rjeid.com/1560-9529/article/view/654105
- DOI: https://doi.org/10.17816/EID654105
- EDN: https://elibrary.ru/PNJZOL
- ID: 654105
Cite item
Abstract
The earliest references to surgical hand antisepsis in Russia date back to the 18th century and are associated with the Russian physician Daniil Samoylovich, who, during a plague epidemic in Moscow, suggested treating hands with a vinegar-based solution when performing surgical opening of plague buboes. Subsequently, in the late 19th and early 20th centuries, the development of surgical hand antisepsis in Russia was influenced by European surgical schools, though it retained its distinct features shaped by the priority of addressing battlefield surgery needs and the use of available chemical agents with antiseptic properties in practice.
In the Soviet period, methods of surgical antisepsis were adjusted in line with the recommendations of national surgical schools, including adaptations made during wartime. This period was marked by the centralization of scientific research and its discussion within the professional medical community, followed by implementation into practice. The most important achievement of this period was the standardization and simplification of antiseptic techniques, which ensured their effectiveness in military field settings despite scarcity of time and resources.
This article provides a retrospective analysis of literary sources reflecting the evolution of surgical hand antisepsis technologies and practices in the USSR from 1917 to 1991. It highlights the contributions of domestic scientists to the advancement of the theory and practice of surgical antisepsis, as well as their prominent efforts in ensuring biosafety.
Full Text

About the authors
Evgeny I. Sisin
Khanty-Mansiysk State Medical Academy; Center for Hygiene and Epidemiology in the Khanty-Mansiysk Autonomous Okrug ― Yugra
Author for correspondence.
Email: evg-sisin1@yandex.ru
ORCID iD: 0000-0001-5003-1110
SPIN-code: 2422-3870
MD, Cand. Sci. (Medicine), Associate Professor
Russian Federation, Khanty-Mansiysk; Khanty-MansiyskAlla A. Golubkova
Central Research Institute of Epidemiology; Russian Medical Academy of Continuous Professional Education
Email: allagolubkova@yandex.ru
ORCID iD: 0000-0003-4812-2165
SPIN-code: 6133-2572
MD, Dr. Sci. (Medicine), Professor
Russian Federation, Moscow; MoscowIrina I. Kozlova
Khanty-Mansiysk State Medical Academy; Center for Hygiene and Epidemiology in the Khanty-Mansiysk Autonomous Okrug ― Yugra
Email: epid_fgu3@xmao.su
ORCID iD: 0000-0002-3345-1786
Russian Federation, Khanty-Mansiysk; Khanty-Mansiysk
Olga A. Ezhova
Department of Healthcare of Khanty-Mansiysk Autonomous Okrug ― Yugra; Nyagan City Clinic
Email: epid@inbox.ru
ORCID iD: 0000-0002-4277-5723
SPIN-code: 6612-5090
Russian Federation, Khanty-Mansiysk; Nyagan
Ksenia I. Berezikova
Khanty-Mansiysk State Medical Academy
Email: berezikova_ksenia@mail.ru
ORCID iD: 0009-0001-1380-7423
SPIN-code: 8425-4900
Russian Federation, Khanty-Mansiysk
Inna E. Gorbunova
Khanty-Mansiysk State Medical Academy
Email: innagorbunova25@gmail.com
ORCID iD: 0009-0007-0978-7822
SPIN-code: 1345-3895
Russian Federation, Khanty-Mansiysk
References
- Orlova O, Akimkin VG. Organization of epidemiological surveillance of infections in the field of surgical intervention. Public Health and Life Environment. 2018;303(6):45–48. doi: 10.35627/2219-5238/2018-303-6-45-48 EDN: XTSPUL
- Brusina EB, Kovalishena OV, Tsigelnik AM. Healthcare-associated infections: Trends and prevention prospectives. Epidemiology & Vaccinal prevention. 2017;18(4):73–80. doi: 10.31631/2073-3046-2017-16-4-73-80 EDN: ZEPLCR
- Hesse ER, Girgolava SS, Shaak VA. General surgery: Manual for physicians and students. Vol. 1. Leningrad: Gosudarstvennoe izdatel’stvo biologicheskoi i meditsinskoi literatury; 1934. P. 42–84. (In Russ.)
- De Vries JJ, Baas WH, van der Ploeg K, et al. Outbreak of Serratia marcescens colonization and infection traced to a healthcare worker with long-term carriage on the hands. Infect Control Hosp Epidemiol. 2006;27(11):1153–1158. doi: 10.1086/508818
- McNeil SA, Nordstrom-Lerner L, Malani PN, et al. Outbreak of sternal surgical site infections due to Pseudomonas aeruginosa traced to a scrub nurse with onychomycosis. Clin Infect Dis. 2001;33(3):317–323. doi: 10.1086/321890
- Vos MC, Memish ZA. The health care worker as a source of transmission. Chapter 11: Guide to infection control in the hospital. Boston, MA: International Society for Infectious Diseases; 2018.
- Samoïlowitz D. Mémoire sur la peste, qui, en 1771, ravagea l’empire de Russie, sur-tout Moscou, la capitale. Paris; 1783.
- Oppel VA. History of Russian surgery: A critical sketch. Vologda: Izdanie Vologodskogo oblastnogo otdeleniya gosudarstvennogo izdatel’stva; 1923. 409 р. (In Russ.)
- Gostischev VK. General surgery. Moscow: GEOTAR-Media; 2022. 736 р. (In Russ.)
- Merzlikin NV, Komkova TB, Tskhai VF, et al. General surgery. Moscow: GEOTAR-Media; 2023. 1016 р. (In Russ.) doi: 10.33029/9704-7806-6-OBX-2023-1-1016 EDN: DAXUTK
- Petrov SV, Semyonov AY, Fionik OV, et al. General surgery. Moscow: GEOTAR-Media; 2023. 832 р. (In Russ.)
- Sisin EI, Golubkova AA, Kozlova II, et al. Urgical antisepsis in Russia: Historical parallels. Epidemiology and infectious diseases. 2024;29(3):236–247. doi: 10.17816/EID630074 EDN: CPVUAK
- Lidskii AT. Comparative evaluation of modern methods of hand disinfection. In: Collection of works on obstetrics and gynecology, dedicated to Professor Vitorin Sergeyevich Gruzdev by his students on the 25th anniversary of his medical and scientific activity. Petrograd; 1917–1923. Р. 191–294. (In Russ.)
- Smorodintsev AA. Comparative evaluation of the most important methods of hand disinfection. Vestnik khirurgii i pogranichnykh oblastei. 1929;(17):24–37. (In Russ.)
- Okunevsky JL. Practical guide to disinfection. Part 3. Moscow; Leningrad: Medgiz; 1932–1936. (In Russ.)
- Bakkal SA. Sterilization of surgeon’s hands at the front and in the rear. In: Collection of scientific papers dedicated to the seventieth anniversary of Academician Vladimir Petrovich Filatov. Odessa: Odesskoe oblastnoe izdatel’stvo; 1946. Р. 33–38. (In Russ.)
- Kochergin IG. Preparation of the surgeon’s hands and the operating field. Kuibyshev: Gosudarstvennoe izdatel’stvo Sovetskaya nauka; 1941. 116 р. (In Russ.)
- Ustyugov PK, editor. Military field surgery. Moscow: Medgiz; 1942. 358 р. (In Russ.)
- Velikoretsky AN. Textbook of surgery for nurses. Moscow: Medgiz; 1941. 316 р. (In Russ.)
- Faerman IL. Bactericide: Collection of experimental works. Moscow: Izdanie Pervogo Moskovskogo meditsinskogo instituta; 1938. 268 р. (In Russ.)
- Fabrikant IE, Plisan OG. Comparative evaluation of in vitro actions of the newest bactericidal substances. Vestnik khirurgii. 1939;(57):262–269. (In Russ.)
- Zbarsky IB. Object No. 1. Moscow: Vagrius; 2000. 315 р. (In Russ.)
- Kaverin ID. Simplified and cheap methods of treatment of the skin of surgeon’s hands and surgical field [dissertation]. Sverdlovsk; 1951. 327 р. (In Russ.)
- Vasilchuk VM. Treatment of hands and operating field with ammonium chloride in alcohol. Khirurgiia. 1937;(4):37. (In Russ.)
- Aminev AM. Once again about rubber gloves. Khirurgiia. 1937;(4):131–136. (In Russ.)
- Makarenko VA. Application of caustic alkalis for preparation of surgeon’s hands. Vestnik khirurgii. 1939;(57):270–276. (In Russ.)
- Davletov AS. A new method of decontamination of surgeon’s hands, which has advantages in a combat situation. Khirurgiia. 1940;(9):66–69. (In Russ.)
- Temporary methodical recommendations on the organisation and carrying out of a complex of sanitary-hygienic measures in departments, hospitals, clinics and institutes of surgical profile’, approved by the Ministry of Health of the USSR on December 29, 1973. Moscow; 1974. 28 р. (In Russ.)
- Methodical recommendations. Modern methods of processing the surgeon’s hands and the surgical field; Approved by the Head of the Department for the Introduction of New Medicines and Medical Equipment Moscow; On April 4, 1979 13 p. (In Russ.)
- Lepakhin VK, Olefir YV, Merkulov VA, et al. History of creation and development of the control and approval system of medicines in Russia (25 years since the establishment of the first state institution for expert evaluation of medicines). Bulletin of the scientific centre for expert evaluation of medicinal products. 2016;(1):3–10. (In Russ.)
- Brook AM. Cold sterilization of rubber gloves: Collection of works of 4 surgical clinic. Izdanie 2-go klingorodka Narkomzdrava BSSR; 1941. Р. 73–95. (In Russ.)
- Chulanov BI. Application of Soviet chloramine B in the treatment of surgeon’s hands. Khirurgiia. 1949. Р. 84–85. (In Russ.)
- Makarenko VA. New way of preparation of surgeon’s hands. Theses of reports. 1962. Р. 301–303. (In Russ.)
- Guzenko PC. Disinfection of hands in the shortest possible time at mass work of a surgeon [dissertation]. Moscow; 1961. (In Russ.)
- Shaufler KK. New antiseptic agent Chloracid. Kazan medical journal. 1937;33(2):211–212. (In Russ.)
- Antelava NV. Chloracid and its application in military surgery. Tbilisi: Gruzmedgiz; 1942. 42 р. (In Russ.)
- Naftoliev YA, Reicher VI. Application of monosept solution in the treatment of hands according to the method of Spasokukotsky. Voenno-meditsinskii zhurnal. 1948;(7):42. (In Russ.)
- Kiyashev AP. Preoperative treatment of surgeon’s hands. Grekov’s bulletin of Surgery. 1963;90(6):125–126. (In Russ.)
- Trofimenko TD. On the preparation of surgeon’s hands for surgery. Zdravookhranenie Kazakhstana. 1953;(8):30–33. (In Russ.)
- Ikramov ZH. Method of preparation of surgeon’s hands with antibiotics. Zdravookhranenie Tadzhikistana. 1955;(4):22–23. (In Russ.)
- Akhutin MN. Surgical work during the fighting at Lake Khasan. In: Proceedings of the XXIV All-Union Congress of Surgeons. Moscow; Leningrad: Medgiz; 1939. Р. 97–109. (In Russ.)
- Milovidova MA. Preparation of surgeon’s hands with detergents and the role of airborne infection in the operating theatre [dissertation abstract]. Moscow: [b. i.]; 1968. 16 р. (In Russ.)
- Gladinets MM. Bacteriological and clinical evaluation of treatment of surgeon’s hands and surgical field by some chemical and vegetable agents [dissertation abstract]. Alma-Ata: [b. i.]; 1972. 19 р. (In Russ.)
- Volosovets PS, Dolnitsky OV, Chernyavskaya VG. Experience of application of novoimanin for disinfection of hands and surgical field. In: Drobotko VG, editor. Phytoncides, their biological role and importance for medicine and national economy. Kiev: Naukova dumka; 1967. Р. 242–244. (In Russ.)
- Makeev VD, Koposov NA, Usov DV. Processing of surgeon’s hands. Grekov’s bulletin of Surgery. 1961;86:119–120. (In Russ.)
- Kashkina EG, Osipov SN. Treatment of hands and surgical field with Liquatol. Grekov’s bulletin of Surgery. 1967;98(1):19–21. (In Russ.)
- Melekhov PA, Melekhov EP. Application of Pervomur in surgery. Khirurgiia. 1990;66(9):98–103. (In Russ.)
- Melekhov PA. Thirty years’ experience in the use of Pervomur in emergency surgery according to the author’s method. In: Theses of reports of the scientific-practical conference devoted to the 100th anniversary of the organisation of emergency medical aid in St. Petersburg “Organizatsionnye i klinicheskie aspekty raboty skoroi meditsinskoi pomoshchi”. Saint Peterburg; 1999. Р. 110–111. (In Russ.) EDN: XMZQIB
- Gadzhiev SA, Ryvkin AY, Sovinsky YR. Disinfectants in surgical clinic. Khirurgiia. 1971;47:92–95. (In Russ.)
- Belyakov VD, Kolesov AP, Ostroumov PB, Nemchenko VI. Hospital infection. Leningrad; 1976. 231 р. (In Russ.)
- Patent RUS № SU 239503 A1. Byul. № 11. Hramenitskaya VG, Kostyukovsky JL, Osipyan VT, et al. Method of disinfection of objects. (In Russ.) Available from: https://yandex.ru/patents/doc/SU239503A1_19690318?ysclid=m8q5hkdkma822986864 Accessed: Nov 15, 2024. EDN: XHTIXG
- Trishkin DV, Kryukov EV, Chuprina AP, et al. Methodological recommendations for the treatment of combat surgical trauma. Saint Peterburg; 2022. 373 р. (In Russ.) EDN: MHOUOD
- Pharmacological Committee of the Ministry of Health of the USSR. Instructions for the use of disinfectant soap Hexafen for hand washing. In: Proceedings of the Central Research Disinfection Institute. Issue 12. Moscow; 1959. Р. 271. (In Russ.)
- Vashkov VI, Chadova EK, Sukhareva ND, et al. Experience in the use of hexachlorophene soap for hand treatment in practical conditions. In: Boldyreva ТЕ, Vashkova VI, editors. Proceedings of the Central Research Disinfection Institute. 1959;(12):20–25. (In Russ.)
- Vashkov VI, Sokolov NF, Serebryakova EK. Development of methods of hand disinfection with hexylresorcin solutions. In: Boldyreva ТЕ, Vashkova VI, editors. Proceedings of the Central Research Disinfection Institute. 1959;(12):29–35. (In Russ.)
- Vashkov VI. Modern antiseptics for skin treatment: A collection of scientific papers. Issue 25. Moscow; 1976. Р. 20–22. (In Russ.)
- Skala LZ. Antimicrobial properties of some iodophores and their application for hand and skin disinfection [dissertation abstract]. Moscow: [b. i.]; 1968. 23 р. (In Russ.)
- Kurtenok LG. Comparative evaluation of modern methods of treatment of surgeon’s hands and the operating field in clinical aspect [dissertation abstract]. Moscow: [b. i.]; 1979. 19 р. (In Russ.)
- Nehorosheva AG, Skvortsova EK. Effectiveness of metacide-2 in hand skin disinfection. In: Shilova SA, editor. Problems of disinfection and sterilisation: Collection of scientific papers. Issue 24. Moscow; 1975. Р. 62–66. (In Russ.)
- Nehorosheva AG, Skvortsova EK. Evaluation of the effectiveness of cationic antimicrobial agents in hand skin disinfection. In: Shilova SA, editor. Problems of disinfection and sterilisation: Collection of scientific papers. Issue 23. Moscow; 1974. Р. 96–100. (In Russ.)
- Patent RUS № SU 291546/1975.09.05. Abelevich IG, Degtyareva LM, Pavlova TV, Etlis VS. Composition for treatment of surgeon’s hands. (In Russ.) Available from: https://yandex.ru/patents/doc/SU291546A1_19750905?ysclid=m8r4grdvga140112141 Accessed: Nov 15, 2024.
- Osipyan VT, Rachinsky FY, Krupenina AA, et al. Degmin: A new effective disinfectant. Voenno-meditsinskii zhurnal. 1968;289:55–57. (In Russ.)
- Popov LN. Comparative evaluation of some modern methods of treatment of surgeon’s hands [dissertation abstract]. Leningrad; 1975. 12 р. (In Russ.)
- Uglov FG, Zubtsovsky VN, Neklasov YF, et al. Application of new antiseptic agents in surgical clinic. Khirurgiia. 1969;45(5):3–6. (In Russ.)
- Patent RUS № SU 1103398 А1/2000.03.27. Rodoman VE, Cherkashin MI, Misin VM, et al. Antiseptic composition ‘Apolam’. (In Russ.) Available from: https://yandex.ru/patents/doc/SU1103398A1_20000327?ysclid=m8r4x89hg7476861894 Accessed: Nov 15, 2024.
- Skvortsova EK, Nekhorosheva AG. Evaluation of the effectiveness of cationic antimicrobial substances in hand skin disinfection. In: Shilova SA, editor. Problems of disinfection and sterilisation: Collection of scientific papers. Issue 23. Moscow; 1974. Р. 96–99. (In Russ.)
- Buyanov VM, Rodoman GV, Khrupalov AA, et al. Evaluation of the effectiveness of the antiseptic preparation ‘Apolam’ for the treatment of surgeon’s hands. Sovetskaya meditsina. 1990;53(8):29–33. (In Russ.)
- Osherovich DL, Stepanova LB. Anhydrous method of treatment of surgeon’s hands and elbow bends of donors with the preparation ‘Novosept’. Hematology and transfusiology. 1966;11(1):52–54. (In Russ.)
- Sukiasyan AN, Sokolova NF, Obukhova NV, Kopylova AI. Influence of lower alcohols on the effectiveness of peroxide preparations in hand disinfection. In: Sokolova NF, editor. Modern methods and means of disinfection and sterilisation: Collection of scientific papers. Moscow; 1989. Р. 27–32. (In Russ.)
- Pkhakadze TY, Bogomolova NS, Vinogradova LN. New antiseptics and disinfectants in surgery. Khirurgiia. 1996;(1):52–56. (In Russ.)
- Afinogenov GE, Elinov NP. Antiseptics in surgery. Leningrad; 1987. 143 р. (In Russ.)
- Rubinov GE, Zavrazhnova TV, Matyushina GP, et al. Means and methods of preoperative treatment of surgeon’s hands. Epidemiology and Infectious Diseases. 1998;(2):56–58. (In Russ.)
- Kovaleva EP, Semina NA, editors. Prevention of nosocomial infections: A guide for doctors. Moscow: Rarog; 1993. 228 р. (In Russ.)
- Fedorova LS, Arefieva LI, Putintseva LS, et al. Modern means of disinfection and disinsection: Characteristics, purpose, prospects. Moscow: Soyuzmedinform; 1991. (In Russ.)
- Ovchinnikov VA, Abelevich IG, Ovchinnikov EA. To the history of hand processing in the surgical clinic of the Nizhny Novgorod Regional Clinical Hospital named after N.A. Semashko: Collection of scientific papers. Issue 3. Nizhny Novgorod; 2013. Р. 21–24. (In Russ.)
- Sukiasyan AN, Sokolova NF, Kopylova AI, et al. Use of cyclimide for hygienic hand disinfection. Disinfection and sterilisation. Prospects of development. Volgograd; 1983. 130 р. (In Russ.)
- Tsvetkova AM, Lyarsky PP. Hygienic evaluation of the effect of antiseptic agent cyclimide on the state of barrier-protective properties of the skin. Hygiene & Sanitation. 1991;(4):46–47. (In Russ.)
- Novoderezhkin NN. Antiseptics used in surgical practice in Germany: Collection of scientific information. Issue 1. 1947. Р. 52–55. (In Russ.)
- Lowbury EJ, Lilly HA, Ayliffe GA. Preoperative disinfection of surgeons’ hands: Use of alcoholic solutions and effects of gloves on skin flora. Br Med J. 1974;4(5941):369–372. doi: 10.1136/bmj.4.5941.369
- Cochrane WA. Preparation of the hands for operation. Br Med J. 1942;28:635.
- Loshonzi D. Hospital-acquired infections. Transl. from Hungarian by Ivanov AN, Gostischev VK, editor. Moscow: Medicine; 1978. 453 р. (In Russ.)
- Bidevkina MV, Baklanova OV, Rysina TZ, et al. Comparative toxicity of certain alcohols and alcohol-based skin antiseptics. Toxicological Review. 2016;(2):19–24. EDN: VZCKPV 18. Weatherly LM, Gosse JA. Triclosan exposure, transformation, and human health effects. Journal of Toxicology and Environmental Health. 2017;20(8):447–469. doi: 10.1080/10937404.2017.1399306
- Scherertz RJ, Hampton AL, Ristuzzia PA, et al. Hospital-acquired infections. Wenzel RP, editor. Transl from English by B.A. Godovanny. Moscow: Medicine; 1990. 654 р. (In Russ.)
Supplementary files
