Possibilities of modern methods of laboratory diagnostics in the study of viral hepatitis A

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Abstract

It is generally accepted that the course of viral hepatitis A is accompanied by short-term viremia, and the disease itself does not have serious consequences for the person who has recovered. The article describes a clinical case of a protracted course of viral hepatitis A with long-term persistence of the virus. Against the background of the therapy, the patient's condition improved, and by the time of discharge from the hospital on the 38th day of illness and later, with a retrospective examination on the 68th day from the onset of the disease by the method of reverse transcription PCR (RT-PCR in real time), the presence of RNA of the hepatitis A virus was confirmed in feces, which indicated a long persistence of the virus in the body. This observation indicates the need for long-term dispensary observation of patients who have undergone viral hepatitis A.

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About the authors

Elena V. Volchkova

The First Sechenov Moscow State Medical University

Email: antononina@rambler.ru
ORCID iD: 0000-0003-4581-4510
SPIN-code: 3342-4681

MD, Dr. Sci. (Med), Professor

Russian Federation, 8 bld. 2 Trubetskaya street, 119991, Moscow

Olga F. Belaya

The First Sechenov Moscow State Medical University

Email: ofbelaya@mail.ru
ORCID iD: 0000-0002-2722-1335
SPIN-code: 3921-7227

MD, Dr. Sci. (Med.), Professor

Russian Federation, 8 bld. 2 Trubetskaya street, 119991, Moscow

Karina T. Umbetova

The First Sechenov Moscow State Medical University

Email: karinasara@inbox.ru
ORCID iD: 0000-0003-0902-9267
SPIN-code: 3197-9205

MD, Dr. Sci. (Med.), Professor

Russian Federation, 8 bld. 2 Trubetskaya street, 119991, Moscow

Natalia Y. Pshenichnaya

Central Research Institute of Epidemiology

Email: natalia-pshenichnaya@yandex.ru
ORCID iD: 0000-0003-2570-711X
SPIN-code: 5633-7265

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow

Valerii A. Malov

The First Sechenov Moscow State Medical University

Email: valmalov@list.ru
ORCID iD: 0000-0002-6157-1654
SPIN-code: 4790-8986

MD, Dr. Sci. (Med.), Professor

Russian Federation, 8 bld. 2 Trubetskaya street, 119991, Moscow

Yulia A. Konnova

Infectious diseases Hospital № 2

Author for correspondence.
Email: konnova.yulia@gmail.com
ORCID iD: 0000-0003-3091-2433
SPIN-code: 7856-0880

MD, Cand. Sci. (Med.)

Russian Federation, Moscow

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