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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Epidemiology and Infectious Diseases</journal-id><journal-title-group><journal-title xml:lang="en">Epidemiology and Infectious Diseases</journal-title><trans-title-group xml:lang="ru"><trans-title>Эпидемиология и инфекционные болезни</trans-title></trans-title-group></journal-title-group><issn publication-format="print">3034-2007</issn><issn publication-format="electronic">3034-2015</issn><publisher><publisher-name xml:lang="en">Eco-Vector</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">82724</article-id><article-id pub-id-type="doi">10.17816/EID82724</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Case reports</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Клинические случаи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Possibilities of modern methods of laboratory diagnostics in the study of viral hepatitis A</article-title><trans-title-group xml:lang="ru"><trans-title>Возможности современных методов лабораторной диагностики в изучении вирусного гепатита А</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-4581-4510</contrib-id><contrib-id contrib-id-type="spin">3342-4681</contrib-id><name-alternatives><name xml:lang="en"><surname>Volchkova</surname><given-names>Elena V.</given-names></name><name xml:lang="ru"><surname>Волчкова</surname><given-names>Елена Васильевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>antononina@rambler.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2722-1335</contrib-id><contrib-id contrib-id-type="spin">3921-7227</contrib-id><name-alternatives><name xml:lang="en"><surname>Belaya</surname><given-names>Olga F.</given-names></name><name xml:lang="ru"><surname>Белая</surname><given-names>Ольга Федоровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>ofbelaya@mail.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0902-9267</contrib-id><contrib-id contrib-id-type="spin">3197-9205</contrib-id><name-alternatives><name xml:lang="en"><surname>Umbetova</surname><given-names>Karina T.</given-names></name><name xml:lang="ru"><surname>Умбетова</surname><given-names>Карина Туракбаевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>karinasara@inbox.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2570-711X</contrib-id><contrib-id contrib-id-type="spin">5633-7265</contrib-id><name-alternatives><name xml:lang="en"><surname>Pshenichnaya</surname><given-names>Natalia Y.</given-names></name><name xml:lang="ru"><surname>Пшеничная</surname><given-names>Наталья Юрьевна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>natalia-pshenichnaya@yandex.ru</email><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6157-1654</contrib-id><contrib-id contrib-id-type="spin">4790-8986</contrib-id><name-alternatives><name xml:lang="en"><surname>Malov</surname><given-names>Valerii A.</given-names></name><name xml:lang="ru"><surname>Малов</surname><given-names>Валерий Анатольевич</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Dr. Sci. (Med.), Professor</p></bio><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><email>valmalov@list.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3091-2433</contrib-id><contrib-id contrib-id-type="spin">7856-0880</contrib-id><name-alternatives><name xml:lang="en"><surname>Konnova</surname><given-names>Yulia A.</given-names></name><name xml:lang="ru"><surname>Коннова</surname><given-names>Юлия Александровна</given-names></name></name-alternatives><address><country country="RU">Russian Federation</country></address><bio xml:lang="en"><p>MD, Cand. Sci. (Med.)</p></bio><bio xml:lang="ru"><p>к.м.н.</p></bio><email>konnova.yulia@gmail.com</email><xref ref-type="aff" rid="aff3"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">The First Sechenov Moscow State Medical University</institution></aff><aff><institution xml:lang="ru">Первый Московский государственный медицинский университет имени И.М. Сеченова (Сеченовский Университет)</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Central Research Institute of Epidemiology</institution></aff><aff><institution xml:lang="ru">Центральный научно-исследовательский институт эпидемиологии</institution></aff></aff-alternatives><aff-alternatives id="aff3"><aff><institution xml:lang="en">Infectious diseases Hospital № 2</institution></aff><aff><institution xml:lang="ru">Инфекционная клиническая больница № 2</institution></aff></aff-alternatives><pub-date date-type="preprint" iso-8601-date="2021-10-11" publication-format="electronic"><day>11</day><month>10</month><year>2021</year></pub-date><pub-date date-type="pub" iso-8601-date="2020-11-15" publication-format="electronic"><day>15</day><month>11</month><year>2020</year></pub-date><volume>25</volume><issue>6</issue><issue-title xml:lang="en"/><issue-title xml:lang="ru"/><fpage>264</fpage><lpage>268</lpage><history><date date-type="received" iso-8601-date="2021-10-06"><day>06</day><month>10</month><year>2021</year></date><date date-type="accepted" iso-8601-date="2021-10-07"><day>07</day><month>10</month><year>2021</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2020, Eco-vector</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2020, ООО "Эко-вектор"</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="en">Eco-vector</copyright-holder><copyright-holder xml:lang="ru">ООО "Эко-вектор"</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/"/></permissions><self-uri xlink:href="https://rjeid.com/1560-9529/article/view/82724">https://rjeid.com/1560-9529/article/view/82724</self-uri><abstract xml:lang="en"><p>It is generally accepted that the course of viral hepatitis A is accompanied by short-term viremia, and the disease itself does not have serious consequences for the person who has recovered. The article describes a clinical case of a protracted course of viral hepatitis A with long-term persistence of the virus. Against the background of the therapy, the patient's condition improved, and by the time of discharge from the hospital on the 38th day of illness and later, with a retrospective examination on the 68th day from the onset of the disease by the method of reverse transcription PCR (RT-PCR in real time), the presence of RNA of the hepatitis A virus was confirmed in feces, which indicated a long persistence of the virus in the body. This observation indicates the need for long-term dispensary observation of patients who have undergone viral hepatitis A.</p></abstract><trans-abstract xml:lang="ru"><p>Принято считать, что течение вирусного гепатита А сопровождается кратковременной вирусемией, а само заболевание не имеет серьёзных последствий для переболевшего. В статье описан клинический случай затяжного течения вирусного гепатита А с длительной персистенцией вируса. На фоне проводимой терапии состояние пациентки улучшилось, и к моменту выписки из стационара на 38-й день болезни, как и в дальнейшем при ретроспективном обследовании на 68-й день от начала заболевания методом полимеразной цепной реакции с обратной транскрипцией в реальном времени было подтверждено наличие РНК вируса гепатита А в фекалиях, что свидетельствовало о длительной персистенции вируса в организме. Данное наблюдение свидетельствует о необходимости длительного диспансерного наблюдения за больными, перенёсшими вирусный гепатит А.</p></trans-abstract><kwd-group xml:lang="en"><kwd>viral hepatitis A</kwd><kwd>HAV RNA</kwd><kwd>persistence</kwd><kwd>diagnostics</kwd><kwd>real time RT-PCR</kwd><kwd>case report</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>вирусный гепатит А</kwd><kwd>РНК вируса гепатита А</kwd><kwd>ВГА РНК</kwd><kwd>персистенция</kwd><kwd>диагностика</kwd><kwd>полимеразная цепная реакция с обратной транскрипцией в реальном времени</kwd><kwd>ОТ-ПЦР</kwd><kwd>клинический случай</kwd></kwd-group><funding-group/></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><citation-alternatives><mixed-citation xml:lang="en">Wilkinson BI, Rain T, Wiles K, et al. Oxford handbook of clinical medicine. Tenth edition. Oxford University Press; 2017. 278 p.</mixed-citation><mixed-citation xml:lang="ru">Wilkinson B.I., Rain T., Wiles K., et al. 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