Email this article Features of the profile of drug resistance to first-line and second-line anti-tuberculosis drugs in patients with human immunodeficiency virus infection
- Authors: Bulycheva E.V.1, Bulychev V.V.2, Velichko E.N.1, Pashkova N.A.2
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Affiliations:
- Orenburg State Medical University
- Orenburg Regional Clinical Tuberculosis Dispensary
- Issue: Vol 28, No 4 (2023)
- Pages: 218-229
- Section: ORIGINAL STUDIES
- URL: https://rjeid.com/1560-9529/article/view/448391
- DOI: https://doi.org/10.17816/EID448391
- ID: 448391
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Abstract
BACKGROUND: Drug resistance to anti-tuberculosis drugs directly affects the disease course. However, a high percentage of multidrug resistance in patients with HIV infection not only worsens the disease course but also forces the development of new strategies for managing such patients.
AIMS: To characterize drug resistance to anti-tuberculosis drugs in patients with HIV infection.
MATERIALS AND METHODS: The study recruited patients with newly diagnosed tuberculosis by molecular genetic research methods and bacterial research methods in the Orenburg Regional Clinical Tuberculosis Dispensary.
RESULTS: For 2018–2022, the proportion of people with HIV infection who are resistant to isoniazid by 14.6%, rifampicin by 28.85%, moxifloxacin by 717.39%, and amikacin by 104.25% has increased. The reduction in the choice of drugs and possibility of effective anti-tuberculosis therapy in people with HIV infection are also complicated by the detection of a multidrug-resistant culture in 20.34% of the examined patients and multidrug resistance in 39.6%. In over 5 years, the percentage of gene mutations of mycobacteria responsible for resistance to anti-tuberculosis drugs has increased.
CONCLUSIONS: The results of this study indicate the need to search for new solutions and prevent resistance to existing anti-tuberculosis drugs and for the development of new drugs effective for use as first- and second-line drugs.
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About the authors
Ekaterina V. Bulycheva
Orenburg State Medical University
Author for correspondence.
Email: e-sosnina@mail.ru
ORCID iD: 0000-0002-8215-8674
SPIN-code: 8985-3210
MD, Cand. Sci. (Med.), Assistant Professor
Russian Federation, OrenburgVyacheslav V. Bulychev
Orenburg Regional Clinical Tuberculosis Dispensary
Email: vbolychev@yandex.ru
ORCID iD: 0000-0001-5963-4380
Russian Federation, Orenburg
Elena N. Velichko
Orenburg State Medical University
Email: lena.velichko.2012@mail.ru
ORCID iD: 0009-0005-5419-9574
Russian Federation, Orenburg
Nataya A. Pashkova
Orenburg Regional Clinical Tuberculosis Dispensary
Email: pashkova.dom@mail.ru
ORCID iD: 0000-0002-1735-357X
Russian Federation, Orenburg
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