Email this article Efficiency of treatment with first-line drugs in patients with recurrent tuberculosis of different types of drug resistance on the basis of cohort analysis
- Authors: Khauadamova G.T.1, Abildaev T.S.1, Rakisheva A.S.1, Myasnikova G.A.1, Besstrashnova Y.V.1, Khauadamova GT2, Abildayev TS.2, Rakisheva AS2, Myasnikova GA2, Besstrashnova Y.V2
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Affiliations:
- National Center for Tuberculosis Problems of the Republic of Kazakhstan, Almaty
- Issue: Vol 16, No 6 (2011)
- Pages: 33-38
- Section: Articles
- URL: https://rjeid.com/1560-9529/article/view/40641
- DOI: https://doi.org/10.17816/EID40641
- ID: 40641
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Abstract
A cohort retrospective study was conducted in 94 patients with recurrent pulmonary tuberculosis. The study enrolled more than 18-year-old bacteria-excreting patients admitted to the Therapeutic Unit, National Center for Tuberculosis Problems, in 2006 to 2008. All the patients received category II chemotherapy regimen with first-line drugs.
According to the type of drug resistance, the patients were divided into 3 groups: 1) mono-; 2) poly-; 3) multi-resistance.
The investigation yielded the following results. In shorter periods (3 months), sputum smear conversion was achieved in patients with mono- (90.0%), poly- (64.7%), and multi- (32.8%) resistance. Overall, sputum smear conversion at 5 months was achieved in 90.0, 88.1, and 74.5% cases, respectively.
Positive X-ray changes as decay cavity reduction (70.0%) and closure (30.0%) were most common in the mono-resistance group. On the contrary, X-ray progression was ascertained in poly- (11.7%) and multi- (16.4%) resistant patients.
The cohort analysis showed that the best results of treatment were achieved in mono-resistant patients (90.0%). On the contrary, the worst treatment results were recorded in multi-resistant patients (24.6%). All those who died of tuberculosis (8%) had formed a multi-resistance group.
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About the authors
Gul'nara Tmukhanovna Khauadamova
Email: haua-adam@mail.ru
Tleukhan Shildebaevich Abildaev
Email: info@ncpt.kz
Anar Saduevna Rakisheva
Email: asr.kz@mail.ru
Galina Alekseevna Myasnikova
Email: alekseevna_1965_@mail.ru
Yana Vadimovna Besstrashnova
Email: vadimkyzy@mail.ru
G T Khauadamova
National Center for Tuberculosis Problems of the Republic of Kazakhstan, AlmatyNational Center for Tuberculosis Problems of the Republic of Kazakhstan, Almaty
T Sh Abildayev
National Center for Tuberculosis Problems of the Republic of Kazakhstan, AlmatyNational Center for Tuberculosis Problems of the Republic of Kazakhstan, Almaty
A S Rakisheva
National Center for Tuberculosis Problems of the Republic of Kazakhstan, AlmatyNational Center for Tuberculosis Problems of the Republic of Kazakhstan, Almaty
G A Myasnikova
National Center for Tuberculosis Problems of the Republic of Kazakhstan, AlmatyNational Center for Tuberculosis Problems of the Republic of Kazakhstan, Almaty
Ya V Besstrashnova
National Center for Tuberculosis Problems of the Republic of Kazakhstan, AlmatyNational Center for Tuberculosis Problems of the Republic of Kazakhstan, Almaty
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