A case of lactic acidosis developing during antiretroviral therapy in a patient with HIV infection



Cite item

Full Text

Abstract

The paper describes a clinical case of development of lactic acidosis, a specific delayed complication, in a HIV-infected patient who received antiretroviral therapy (ART) for 1.5 years and was adherent to ART. During the latter, the patient achieved stable clinical, immunological, and virologic effects. However, 1.5 years later, the patient was found to have blood biochemical changes as blood accumulation and elevated levels of lactate; clinical signs of lactic acidosis appeared. His therapy regimen with zidovudine and didanosine was changed to abacavir and lamivudine and pathogenetic therapy was performed, which relieved lactic acidosis.
Long-term adverse reactions of the used drugs, which endanger the long-range goals of ART (the quality of life and its duration in patients), play an important role in patients adherent to ART despite the clinical, immunological, and virologic successes of treatment.

About the authors

D S Konnov

Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare

Email: vlad_konnov@mail.ru
Central Research Institute of Epidemiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare

O G Yurin

Federal Research and Methodological Center for AIDS Prevention and Control, Moscow

Federal Research and Methodological Center for AIDS Prevention and Control, Moscow

References

  1. ВИЧ-инфекция и СПИД: Клинические рекомендации. - М., 2009
  2. Клинические аспекты ВИЧ-инфекции / Под ред. Д. Бартлет, Дж. Галлант. - М., 2007. - С. 120-122.
  3. Лечение и помощь при ВИЧ/СПИДе: клинические протоколы для Европейского региона ВОЗ. 2009 (http://www.euro.who.int/document/e90840R.pdf).
  4. Brinkman K., Smeitink J. A., Romijn J. A., Reiss P. // Lancet. - 1999. - Vol. 354. - P. 1112.
  5. Côté H. C., Brumme Z. L., Craib K. J. // N. Engl. J. Med. - 2002. - Vol. 346. - P. 811.
  6. Guidelines for the Use of Antiretroviral Agents in HIV-1-Infected Adults and Adolescents. - 2009. (http://www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf).
  7. Falcö V., Rodriguez D., Ribera E. et al. // Clin. Infect. Dis. - 2002. - Vol. 34. - P. 838.
  8. John M., Moore C. B., James I. R. // AIDS. - 2001. - Vol. 15. - P. 717.
  9. Miller K. D., Cameron M., Wood L. V. // Ann. Intern. Med. - 2000. - Vol. 133. - P. 192.
  10. Tsiodras S., Mantzoros C., Hammer S., Samore M. // Arch. Intern. Med. - 2000. - Vol. 160. - P. 2050.

Copyright (c) 2010 Eco-vector



Свидетельство о регистрации СМИ № 014448 от 08.02.1996 г. выдано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор). 
Свидетельство о регистрации СМИ ЭЛ № ФС 77 - 80652 от 15.03.2021 г. выдано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies