TLR-2 and TLR-4 expression levels as a prognostic index for recovery from chlamydiasis

Stanislav Stepanovich Bayrakova; Байракова Станислав Степанович; E A Voropaeva; Воропаева Е А; V A Aleshkin; Алешкин В А; S S Afanas'ev; Афанасьев С С; A V Karaulov; Караулов А В; L I Kafarskaya; Кафарская Л И; Yu V Nesvizhskiy; Несвижский Ю В; B A Efimov; Ефимов Б А; A N Shkoporov; Шкопоров А Н; O G Grechishnikova; Гречишникова О Г; S A Levakov; Леваков С А; V A Metel'skaya; Метельская В А; M S Afanas'ev; Афанасьев М С; E A Egorova; Егорова Е А; V V Slobodenyuk; Слободенюк В В; E V Fandeev; Фандеев Е В; A L Bairakova; Bairakova A L; Ye A Voropayeva; Voropayeva Ye A; V A Alyoshkin; Alyoshkin V A; S S Afanasyev; Afanasyev S S; A V Karaulov; Karaulov A V; L I Kafarskaya; Kafarskaya L I; Yu V Nesvizhsky; Nesvizhsky Yu V; B A Yefimov; Yefimov B A; A N Shkoporov; Shkoporov A N; O G Grechishnikova; Grechishnikova O G; S A Levakov; Levakov S A; V A Metelskaya; Metelskaya V A; M S Afanasyev; Afanasyev M S; Ye A Yegorova; Yegorova Ye A; V V Slobodenyuk; Slobodenyuk V V; Ye V Fandeyev; Fandeyev Ye V

doi:10.17816/EID40481

TLR-2 and TLR-4 expression levels as a prognostic index for recovery from chlamydiasis

Authors: Bayrakova S.S.¹, Voropaeva EA¹, Aleshkin VA¹, Afanas'ev SS¹, Karaulov AV¹, Kafarskaya LI¹, Nesvizhskiy Y.V¹, Efimov BA¹, Shkoporov AN¹, Grechishnikova OG¹, Levakov SA¹, Metel'skaya VA¹, Afanas'ev MS¹, Egorova EA¹, Slobodenyuk VV¹, Fandeev EV¹, Bairakova AL², Voropayeva Y.A², Alyoshkin VA², Afanasyev SS², Karaulov AV³, Kafarskaya LI⁴, Nesvizhsky Y.V³, Yefimov BA⁴, Shkoporov AN⁴, Grechishnikova OG², Levakov SA³, Metelskaya VA², Afanasyev MS², Yegorova Y.A², Slobodenyuk VV², Fandeyev Y.V²
Affiliations:
2. G. N. Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology, Russian Inspectorate for the Protection of Consumer Rights and Human Welfare
3. I. M. Sechenov Moscow Medical Academy
4. Russian State Medical University, Russian Agency for Health Care
Issue: Vol 15, No 4 (2010)
Pages: 35-42
Section: Articles
URL: https://rjeid.com/1560-9529/article/view/40481
DOI: https://doi.org/10.17816/EID40481
ID: 40481

Cite item

Abstract

The authors studied an association between the expression of TLR-2 and TLR-4 on the epithelial surfaces of the urogenital tract and the clinical manifestations of female urogenital chlamydial infection. Clinical and laboratory studies were conducted in 41 patients with acute urogenital chlamydial infection, 29 patients with chronic urogenital chlamydial infection, 30 patients with a history of diagnosed urogenital chlamydiasis (the markers of these microorganisms had not been detected in the urogenital tract by any of the used studies for a year), and 32 healthy female donors (a control group). The levels of TLR-2 and TLR-4 can serve as criteria for evaluating the degree of chlamydial infection and the presence of an inflammatory process in patients. The eradication of the pathogen can be judged from the changes in the levels of TLR-2 and TLR-4 in some cases when the causative agent was not identified by laboratory tests before treatment and the diagnosis was established in a patient from the markers that were indirectly indicative of her chlamydial infection. The enhanced protective reaction in the focus of affliction is always accompanied by increased TLR-2 and TLR-4 activation. The low levels of TLR-2 and TLR-4 can indicate that the infectious process may become chronic.

Keywords

urogenital chlamydiasis, cultural diagnosis, pathogen-associated molecular patterns, Toll-like receptors (TLR), nonmicrobial pathogens

References

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TLR-2 and TLR-4 expression levels as a prognostic index for recovery from chlamydiasis

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