Age-related clinical and epidemiological features of meningococcal infection in children and ways of improving therapy

Full Text

Abstract

The paper presents a clinical and laboratory analysis of generalized forms of meningococcal infection (MI) in 90 patients aged 1 month to 18 years. The age-related features of the disease under the present conditions and a relationship of its clinical manifestations to the serogroup of a meningococcus are determined. The implication of endogenous intoxication, proteolysis and a systemic inflammatory reaction in the pathogenesis of MI is established. The expediency of co-administration of antibacterial drugs and systemic enzymes and prolonged infusion therapy for generalized forms of MI is scientifically founded and the efficiency of the proposed therapeutic tactics is proven.

About the authors

Natal'ya Viktorovna Skripchenko

Email: rmtc@mail.ru

Yu V Lobzin

L A Alekseeva

M V Ivanova

A A Vil'nits

V V Karasev

G P Ivanova

E Yu Gorelik

N F Pul'man

A S Kvetnaya

M O Volkova

K O Shevchenko

N V Skripchenko

Research Institute of Childhood Infections, Federal Biomedical Agency

Research Institute of Childhood Infections, Federal Biomedical Agency

Yu V Lobzin

Research Institute of Childhood Infections, Federal Biomedical Agency

Research Institute of Childhood Infections, Federal Biomedical Agency

L A Alekseyeva

Research Institute of Childhood Infections, Federal Biomedical Agency

Research Institute of Childhood Infections, Federal Biomedical Agency

M V Ivanova

Research Institute of Childhood Infections, Federal Biomedical Agency

Research Institute of Childhood Infections, Federal Biomedical Agency

A A Vilnits

Research Institute of Childhood Infections, Federal Biomedical Agency

Research Institute of Childhood Infections, Federal Biomedical Agency

V V Karasev

Research Institute of Childhood Infections, Federal Biomedical Agency

Research Institute of Childhood Infections, Federal Biomedical Agency

G P Ivanova

Research Institute of Childhood Infections, Federal Biomedical Agency

Research Institute of Childhood Infections, Federal Biomedical Agency

Ye Yu Gorelik

Research Institute of Childhood Infections, Federal Biomedical Agency

Research Institute of Childhood Infections, Federal Biomedical Agency

N F Pulman

Research Institute of Childhood Infections, Federal Biomedical Agency

Research Institute of Childhood Infections, Federal Biomedical Agency

A S Kvetnaya

Research Institute of Childhood Infections, Federal Biomedical Agency

Research Institute of Childhood Infections, Federal Biomedical Agency

M O Volkova

Research Institute of Childhood Infections, Federal Biomedical Agency

Research Institute of Childhood Infections, Federal Biomedical Agency

K O Shevchenko

Research Institute of Childhood Infections, Federal Biomedical Agency

Research Institute of Childhood Infections, Federal Biomedical Agency

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