Cardiovascular pathology in HIV infection

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Abstract

Currently, there are indications of an increase in the incidence of cardiovascular pathology in patients with HIV infection in comparison with population data and a higher mortality rate from cardiovascular diseases. The problem of detecting the pathology of the cardiovascular system in patients infected with the human immunodeficiency virus (HIV) is relevant due to the increase in the number of HIV-positive individuals and the established effect of HIV infection on the circulatory organs. In order to identify cardiovascular pathology, two patients with stages III and IV of HIV infection were extensively examined. The examination was carried out using electrocardiography, echocardiography and ultrasound dopplerography. Both clinical cases are presented below, in which pronounced cardiovascular pathology was detected in both cases. As factors influencing the development of pathology of the cardiovascular system, based on the presented clinical examples, drug addiction (long-term intravenous use of surfactants) and pathologies of other internal organs in the development of HIV-mediated opportunistic diseases are considered. Analysis of the course of the disease showed that the lesion can develop in various stages of HIV infection, more often infectious endocarditis is the main diagnosis in patients in stage 3 of HIV infection (the first clinical example), and dilated cardiomyopathy — in the late stages of HIV infection and is considered as a concomitant pathology due to lung and kidney damage (the second clinical example).

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About the authors

Renata G. Tuaeva

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology

Email: 121renata@mail.ru
ORCID iD: 0000-0002-6892-4838
SPIN-code: 3110-0481

MD

Russian Federation, Moscow

Olga K. Loseva

Moscow Scientific and Practical Center of Dermatovenereology and Cosmetology

Author for correspondence.
Email: loseva_ok@mail.ru
ORCID iD: 0000-0002-5033-2746
SPIN-code: 5889-7900

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow

Margarita V. Nagibina

Moscow City Center for AIDS Prevention and Treatment

Email: infector03@gmail.com
ORCID iD: 0000-0001-5327-9824
SPIN-code: 6779-9405

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow

Timur P. Bessarab

Moscow City Center for AIDS Prevention and Treatment

Email: bessarab@spid.ru
ORCID iD: 0000-0001-6565-7407
SPIN-code: 1859-2381

MD, Cand. Sci. (Med.)

Russian Federation, Moscow

References

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  2. Knobel H, Jerico C, Montero M, et al. Global cardiovascular risk in patients with HIV infection: concordance and differences in estimates according to three risk equations. Framingham SCORE and PROCAM. AIDS Patient Care. 2007;21(7):452–457. doi: 10.1089/apc.2006.0165
  3. Savès M, Chêne G, Ducimetière P, et al. Risk factors for coronary heart disease in patients treated for human immunodeficiency virus infection compared with the general population. Clin Infect Dis. 2003;37(2):292–298. doi: 10.1086/375844
  4. Klein D, Leyden W, Xu L. Contribution of immunodeficiency to CHD: cohort study of HIV+ and HIV- Kaiser Permanente members. 18th Conference on Retroviruses and Opportunistic Infections. Boston; 2011. Abstract 810.
  5. Mudritskaya TN, Turna EYu, Zakharova MA, Grigorenko EI. Damage to the cardiovascular system in HIV infection. Crimean Therapeutic Journal. 2014;(2):82–88. (In Russ).
  6. Matievskaya NV, Tokunova IO, Snezhitsky VA. HIV-infection and pathology of the cardiovascular system. Medical News. 2015;249(6):6–12. (In Russ).
  7. Mozgaleva NV, Parkhomenko YuG. Morphofunctional parallels of changes in the conduction system of the heart and working myocardium in infective endocarditis and generalized tuberculosis in the presence of drug addiction and HIV infection. Annals of Arrhythmology. 2017;14(2):81–89. (In Russ).

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