Features of nosocomial infections in patients with severe burn injury

Cover Page


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Nosocomial infections in patients with burn injury is one of the leading problems of modern healthcare. In terms of prevalence, they exceed those in patients with any other pathology. In the conditions of man-made disasters and in everyday life, violation of safety rules leads to burn injury.

To study the prevalence of nosocomial infections in patients with burns, identify risk factors and evaluate the effectiveness of the existing system of epidemiological surveillance of these infections, an analysis of publications on this topic on several information resources was carried out: eLibrary.ru, Google Scholar, PubMed and NCBI.

It was found that the most common form of nosocomial infections in burn patients is a burn wound infection, which is treated by 38.8%, lower respiratory tract infections, including those associated with ventilation aids (19.7%), are in the second position, and bloodstream infections (8.1%) are in the third position. Urinary tract infections do not occupy such a significant place, however, their significant prevalence among patients outside the intensive care and intensive care units has been noted in foreign literature. Despite the available data on the prevalence of certain clinical forms of nosocomial infections, data on risk factors and a number of problematic issues that may be the subject of discussion and require their solution remain controversial. The risks of death are high due to the specifics of burn injury, with its frequent combination with inhalation trauma.

The system of epidemiological surveillance of nosocomial infections in burn centers, including in the intensive care and intensive care units, has some differences in approaches to identifying, recording, registering, and collecting information about the place and time of the greatest risk.

Full Text

Restricted Access

About the authors

Alla A. Golubkova

Central Research Institute of Epidemiology

Email: allagolubkova@yandex.ru
ORCID iD: 0000-0003-4812-2165
SPIN-code: 6133-2572
https://rjeid.com/1560-9529/author/saveSubmit/4

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow

Yuliya Y. Kutlaeva

Ural State Medical University

Author for correspondence.
Email: nostra.87@mail.ru
ORCID iD: 0000-0002-7090-3534
SPIN-code: 6072-1637
https://rjeid.com/1560-9529/user/registerUser#

MD, Cand. Sci. (Med.)

Russian Federation, 3, Repin street, Ekaterinburg, 620028

Vladimir A. Bagin

City Clinical Hospital Nо 40

Email: baginvla@gmail.com
ORCID iD: 0000-0002-5290-1519
SPIN-code: 2190-6891

MD, Cand. Sci. (Med.)

Russian Federation, Ekaterinburg

References

  1. Alekseev AA, Tyurnikov YuI. Analysis of the main statistical indicators of the work of Russian burn hospitals for 2009–2012. In: IV Congress of combustiologists of Russia: collection of scientific papers, October 13–16, Moscow; 2013. Р. 5–8. (In Russ).
  2. Ronald G, Tompkins M, Tompkins R. Survival from burns in the new millennium: 70 years’ experience from a single institution. Ann Surg. 2015;261(2):263–268. doi: 10.1097/SLA.0000000000000623
  3. Falca V, Racasan O, Zbuchea A, еt al. Epidemiologic and bacteriologic study of the burned patients from the plastic surgery department of the county emergency hospital of Ploiesti, over a 4 years period (2010–2013). Chirurgia. 2015;110(4):362–367.
  4. Karpunina TI, Kuznetsova MV, Samartsev VA. Features of infection of burn wounds. News Surgery. 2014;22(2):199–206. (In Russ).
  5. Kanamori H, Parobek CM, Weber DJ, еt al. Next-generation sequencing and comparative analysis of sequential outbreaks caused by multidrug-resistant Acinetobacter baumannii at a large academic burn center. Antimicrob Agents Chemother. 2016;60(3):1249–1257. doi: 10.1128/AAC.02014-15
  6. Lopes M, Wagenr A, Whitaker I, еt al. The association between burn and trauma severity and in-hospital complications. Burns. 2020;46(1):83–89. doi: 10.1097/JTN.0000000000000411
  7. Chen Q, Cui W, Du L, еt al. Clinical characteristics and risk factors of polymicrobial Staphylococcus aureus bloodstream infections. Antimicrob Resist Infect Control. 2020;9(1):76–86. doi: 10.1186/s13756-020-00741-6
  8. Chen IH, Chen CS, Chen YY, еt al. Incidence and mortality of healthcare-associated infections in hospitalized patients with moderate to severe burns. J Critical Care. 2019;54:185–190. doi: 10.1016/j.jcrc.2019.08.024
  9. Novitskaya NV. The epidemic process of wound infections caused by P. aeruginosa and A. baumannii in a burn hospital of a multidisciplinary hospital. Polytrauma. 2010;(4):72–75. (In Russ).
  10. Ibragimova TD, Turkutyukov VB, Morgunova EV. Etiology of purulent-septic complications in burn injury and monitoring of sensitivity of microorganisms to antibiotics. Pacific Med J. 2012;(4):70–72. (In Russ).
  11. Atilla A, Katrancı AO, Tomak L, еt al. Mortality risk factors in burn care units considering the clinical significance of acinetobacter infections. Ulus Travma Acil Cerrahi Derg. 2015;21(1):34–38. doi: 10.5505/tjtes.2015.76814
  12. Blevins MW, Brooks DJ, Holmes IV, еt al. Successful control of a methicillin-resistant Staphylococcus aureus outbreak in a burn intensive care unit by addition of universal decolonization with intranasal mupirocin to basic infection prevention measures. Antimicrob Resist Infect Control. 2019;47(6):661–665. doi: 10.1016/j.ajic.2018.11.016
  13. Cairns BA, Duin D, Jones SW, еt al. Risk factors for healthcare-associated infections in adult burn patients. Infect Control Hosp Epidemiol. 2017;38(12):1441–1448. doi: 10.1017/ice.2017.220
  14. Posluszny JA, Conrad P, Halerz M, еt al. Surgical burn wound infections and their clinical implications. J Burn Care Res. 2011;32(2):324–333. doi: 10.1097/BCR.0b013e31820aaffe
  15. Kiselev AY, Usov VV, Migunova EV, et al. Terms of contamination of burn wounds with nosocomial flora. Pacific Med J. 2020;(1):28–31. (In Russ). doi: 10.34215/1609-1175-2020-1-28-31
  16. Biard L, Donay JL, Flicoteaux R, еt al. Incidence, risk factors and outcome of multi-drug resistant Acinetobacter baumannii nosocomial infections during an outbreak in a burn unit. J Hospital Infection. 2017;97(3):226–233. doi: 10.1016/j.jhin.2017.07.020
  17. Jamulitrat S, Maki DG, Rosenthal VD. International nosocomial infection control consortium (INICC) report, data summary for 2003–2008. Am J Infection Control. 2020;48(4):423–432. doi: 10.1016/j.ajic.2009.12.004
  18. Elizana B, Kristaq M, Petrela Y, еt al. Epidemiology of infections in a burn unit. Burns. 2013;39(7):1456–1467. doi: 10.1016/j.burns.2013.03.013
  19. Satosova NV. Epidemiology and prevention of bloodstream infection in the burn intensive care unit [dissertation abstract]. Saint Petersburg; 2012. 24 р. (In Russ).
  20. Dudeck MA, Horan TC, Peterson KD, еt al. National healthcare safety network (NHSN) report, data summary for 2013, device-associated module. Am J Infection Control. 2013;41(4):286–300. doi: 10.1016/j.ajic.2013.01.002
  21. Beloborodov VB, Gusarov VG, Dekhnich AV, et al. Methodological recommendations. Diagnostics and antimicrobial therapy of infections caused by polyresistant microorganisms. Bulletin Anesthesiology Res. 2020;1(17):52–83. (In Russ). doi: 10.21292/2078-5658-2020-17-1-52-83
  22. Ivanchik NV, Klenova EY, Sukhorukova MV, et al. Antibiotic resistance of nosocomial strains of Pseudomonas aeruginosa in hospitals in Russia: results of a multicenter epidemiological study “Marathon” 2013–2014. Clin Microbiol Antimicrobial Chemotherapy. 2017;19(1):37–41. (In Russ).
  23. Dudareva EV, Nechaeva ES, Sabirova EV, et al. Phenotypic and molecular genetic features of pathogens of wound burn infection. Clin Microbiol Antimicrobial Chemotherapy. 2012;14(4):342–346. (In Russ).
  24. Ortenberg EA, Khokhlyavin RL. Antibacterial therapy of wound burn infection: reserves for its optimization. Med Sci Education Urals. 2012;13(3-1):91–93. (In Russ).
  25. Dudareva EV, Nechaeva ES, Sabirova EV, et al. Features of wound infection pathogens in patients with thermal trauma. Med Almanac. 2012;5(24):181–183. (In Russ).
  26. Fardin M, Moazamian E, Rafati A, еt al. Antimicrobial resistance pattern, genetic distribution of ESBL genes, biofilm-forming potential, and virulence potential of Pseudomonas aeruginosa isolated from the burn patients in Tehran Hospitals, Iran. Pan Afr Med J. 2020;36:233. doi: 10.11604/pamj.2020.36.233.21815
  27. Dou Y, Zhang Q. A single center study on antimicrobial use and bacterial resistance in burn ward. Zhonghua Yi Xue Za Zhi. 2021;47(1):1401–1408. doi: 10.1111/vde.12362
  28. Alves G, Antunes O, Fernandes S, еt al. Carbapenem-resistant Acinetobacter baumannii in patients with burn injury: a systematic review and meta-analysis. Burns. 2019;47(7):1495–1508. doi: 10.1016/j.burns.2019.07.006
  29. Gong Y, Liu C, Luo X, еt al. Epidemiology investigation of carbapenems-resistant Klebsiella pneumoniae in burn care unit. Zhonghua Shao Shang Za Zhi. 2019;35(11):798–803. doi: 10.3760/cma.j.issn.1009-2587.2019.11.006
  30. Dudareva EV, Nechaeva ES, Sabirova EV, et al. The importance of microorganisms of the Enterobacteriaceae family in the etiology of wound burn infection fundamental research. Med Sci. 2013;12:191–194. (In Russ).
  31. Baj J, Buszewicz G, Forma A, еt al. Viral infections in burn patients: a state-of-the-art review. Viruses. 2020;12(11):1315. doi: 10.3390/v12111315
  32. Lazareva EB, Makarov AV, Menshikova ED, et al. Microflora of bronchoalveolar discharge in patients with inhalation trauma: abstracts of the report at the conference. Modern aspects of treatment of thermal trauma. Materials of the scientific and practical conference with international participation dedicated to the 70th anniversary of the first burn center of Russia, June 23–24, Saint Petersburg; 2016. Р. 60–61. (In Russ).
  33. Owlia P, Azimi L, Gholami A, еt al. ESBL- and MBL-mediated resistance in Acinetobacter baumannii: a global threat to burn patients. Infez Med. 2012;20(3):182–187.
  34. Orlova OA, Tutelyan AV, Zamyatin MN, Akimkin VG. Epidemiological diagnostics of infections associated with the provision of medical care at the present stage. Med Alphabet. 2019;3(32):5–10. (In Russ). doi: 10.33667/2078-5631-2019-3-32(407)-5-10
  35. Zueva LP, Aslanov BI, Vasiliev KD, et al. Epidemiological diagnostics ― the basis of risk-oriented technologies for the prevention of hospital infections. Epidemiology Vaccination. 2017;16(5):69–74. (In Russ).
  36. Kulabukhov VV, Chizhov AG, Kudryavtsev AN, еt al. Experience of implementing the concept of «isolated patient» in the intensive care unit. Med Advice. 2013;(5-6):53–58. (In Russ).
  37. Carper C, Faraklas I, Gauthier K, еt al. Assessment of a central line-associated bloodstream infection prevention program in a burn-trauma intensive care unit. JAMA Surgery. 2016;151(5):485–486. doi: 10.1001/jamasurg.2015.4445
  38. Cairns BA, Hultman CS, Jones SW, еt al. Systems-based practice in burn care: prevention, management, and economic impact of health care-associated Infections. Clin Plast Surg. 2017;44(4): 935–942. doi: 10.1016/j.cps.2017.06.002
  39. Baier C, Ebadi E, Ipaktchi R, et al. A multimodal infection control concept in a burn intensive care unit ― lessons learnt from a meticillin-resistant Staphylococcus aureus outbreak. J Hosp Infect. 2018;98(2):127–133. doi: 10.1016/j.jhin.2017.07.023

Copyright (c) 2022 Eco-vector



СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: 014448 от 08.02.1996
СМИ зарегистрировано Федеральной службой по надзору в сфере связи, информационных технологий и массовых коммуникаций (Роскомнадзор).
Регистрационный номер и дата принятия решения о регистрации СМИ: серия ЭЛ № ФС 77 - 80652 от 15.03.2021
.


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies