Email this article Study of the levels of soluble forms of differentiation antigens in patients with herpes zoster
- Authors: Sobchak D.M.1, Korochkina O.V.1, Svintsova T.A.1, Kravchenko G.A.1, Novikov V.V.1, Sobchak DM2, Korochkina OV2, Svintsova TA2, Kravchenko GA2, Novikov VV3
-
Affiliations:
- Nizhni Novgorod State Medical Academy
- N. A. Lobachevsky Nizhni Novgorod State University
- Issue: Vol 16, No 6 (2011)
- Pages: 18-23
- Section: Articles
- URL: https://rjeid.com/1560-9529/article/view/40624
- DOI: https://doi.org/10.17816/EID40624
- ID: 40624
Cite item
Full Text
Abstract
Differentiation antigens (sCD95, sCD18, sCD50, sHLAI, sCD54) was studied by enzyme immunoassay using monoclonal antibodies (Ab) ICO-20 and polyclonal Abs to antigens of human peripheral blood mononuclear cells. A control group included 60 health donors matched with the study group for age and gender.
Age over 60 years, moderate herpes zoster, eruptions on the torso, no comorbidities, and a 1.5-2-fold increase in sHLAI as compared with the reference values were found to be factors that contribute to the uncomplicated course of the disease. The cofactors of postherpetic neuralgia were elderly age (more than 60 years), the severe course of the disease, eruptions on the head, comorbidities, elevated blood urea levels, a 1.5-2-fold decrease in sCD95 and sCD54 as compared to the reference values.
About the authors
Devora Mikhaylovna Sobchak
Ol'ga Vladimirovna Korochkina
Tat'yana Aleksandrovna Svintsova
Galina Anatol'evna Kravchenko
Email: unn@unn.ru
Viktor Vladimirovich Novikov
Email: unn@unn.ru
D M Sobchak
Nizhni Novgorod State Medical AcademyNizhni Novgorod State Medical Academy
O V Korochkina
Nizhni Novgorod State Medical AcademyNizhni Novgorod State Medical Academy
T A Svintsova
Nizhni Novgorod State Medical AcademyNizhni Novgorod State Medical Academy
G A Kravchenko
Nizhni Novgorod State Medical AcademyNizhni Novgorod State Medical Academy
V V Novikov
N. A. Lobachevsky Nizhni Novgorod State UniversityN. A. Lobachevsky Nizhni Novgorod State University
References
- Александров А. В., Джексон А. М., Румянцев А. Г. Анализ механизма модуляции межклеточных молекул адгезии ICAM // Иммунология. - 1997. - № 1. - С. 4-13.
- Бабаев А. А., Новиков В. В., Ежова Г. Г., Добротина Н. А. Белки. Ч. 2: Мембранные белки адгезии: Учеб. пособие. - Н. Новгород, 2004.
- Ершов Ф. И. Антивирусные препараты. - М., 1998.
- Исаков В. А. Современные методы лечения герпетической инфекции // Terra Medica. - 1997. - № 3. - С. 2-6.
- Исаков В. А., Архипова Е. И., Исаков Д. В. Герпетические инфекции человека. - СПб., 2006.
- Новиков В. В. Растворимые формы мембранных белков клеток иммунной системы при вирусных инфекциях // Вестн. Нижегород. ун-та им. Лобачевского. - 2001. - № 4. - С. 208-217.
- Новиков В. В., Добротина Н. А., Бабаев А. А. Иммунология: Учеб. пособие: Н. Новгород, 2005.
- Новиков В. В., Караулов А. В., Барышников А. Ю. Растворимые формы мембранных антигенов клеток иммунной системы. - Н. Новгород, 2008.
- Ющук Н. Д., Венгеров Ю. Я. Лекции по инфекционным болезням. - М., 2007.
- Ярилин А. А., Добротина Н. А. Введение в современную иммунологию. - Н. Новгород, 2004.
- Fleming D. T., McQuillan G. M. et al. Herpes simplex virus type 2 in the United States, 1994 to 2004 // N. Engl. J. Med. - 2004. - Vol. 21, N 16. - P. 1105-1111.
- Dimarco G. S. Management of herpesvirus infections in the immunocompromised host with and without HIV infection // Building International Congress. - London. - 2006. - P. 67.
- Ross J. D., Smith J. W., Elton R. A. The epidemiology of herpes simplex types 1 and 2 infections of the genital tract in Edinburg 1978-1991 // Genitourin. Med. - 2003. - Vol. 65, N 9. - P. 381-383.
- Weber B. Biology of herpes virus infections and tagers of anti viral therapies // International Meeting "Skin Therapy Update, 1994", 14-17 Oct. 1994. - Berlin, 2004. - P. 46.
Supplementary files
