Seroconversion and a rise in IgG antibody concentrations in children with infection caused human herpesvirus type 6

Mikhail Andreevich Nikol'skiy; Никольский Михаил Андреевич; V G Messorosh; Мессорош В Г; S I Minchenko; Минченко С И; M A Nikolsky; Nikolsky M A; V G Messorosh; Messorosh V G; S I Minchenko; Minchenko S I

doi:10.17816/EID40547

Seroconversion and a rise in IgG antibody concentrations in children with infection caused human herpesvirus type 6

Authors: Nikol'skiy M.A.¹, Messorosh VG¹, Minchenko SI¹, Nikolsky MA²^,3, Messorosh VG²^,3, Minchenko SI²^,3
Affiliations:
2. I. P. Pavlov State Medical University
3. N. F. Filatov Children's City Clinical Hospital Five
Issue: Vol 16, No 3 (2011)
Pages: 15-18
Section: Articles
URL: https://rjeid.com/1560-9529/article/view/40547
DOI: https://doi.org/10.17816/EID40547
ID: 40547

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Abstract

The investigation was undertaken to assess whether serodiagnosis of infection caused by human herpesvirus type 6 (HHV-6) could be made in children, by determining IgG antibodies over time. One hundred and seven patients aged 1 month to 5 years who had been admitted to the infectious hospital for complaints of fever without apparent catarrhal symptoms were examined. HHV-6 IgG antibodies were found in 50% of the patients. The presence of the antibodies directly correlated with age - more than 80% of the examinees aged above 2 years had IgG antibodies. Its laboratory diagnosis was verified in 18 patients (among them, there were 14 children with roseola, 3 with rash-free fever, and 1 with recurrent febrile convulsions). Thus, serodiagnosis of HHV-6 infection in children, by determining IgG antibodies over time, is an accessible and informative tool to diagnose exanthema subitum (roseola) or rash-free fever and allows the activity of HHV-6 infection to be followed over time.

Keywords

exanthema subitum, human herpesvirus type 6, febrile convulsions

References

Caselli E., Di Luca D. Molecular biology and clinical associations of Roseoloviruses human herpesvirus 6 and human herpesvirus 7 // New Microbiol. - 2007. - Vol. 30, N 3. - P. 173-187.
Leach C. T. Human herpesvirus-6 and -7 infections in children: agents of roseola and other syndromes // Curr. Opin. Pediatr. - 2000. - Vol. 12, N 3. - P. 269-274.
Suga S., Yoshikawa T., Asano Y. et al. IgM neutralizing antibody responses to human herpesvirus-6 in patients with exanthem subitum or organ transplantation // Microbiol. and Immunol. - 1992. - Vol. 36. - P. 495.
Yamanishi K., Okuno T., Shiraki K. et al. Identification of human herpesvirus-6 as a causal agent for exanthem subitum // Lancet. - 1988. - Vol. 1. - P. 1065.

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Seroconversion and a rise in IgG antibody concentrations in children with infection caused human herpesvirus type 6

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About the authors

Mikhail Andreevich Nikol'skiy

V G Messorosh

S I Minchenko

M A Nikolsky

V G Messorosh

S I Minchenko

References

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