Email this article Mechanisms of an exacerbation of hepatitis B and C in the presence of opisthorchiasis
- Authors: Bychkov VG1, Krylov GG1, Efimova NA1, Mefod'ev V.V.1, Sabirov AK.1, Ibragimova AM1, Khadieva ED1, Bychkov VG2, Krylov GG3, Yefimova NA4, Mefodyev VV2, Sabirov AK.2, Ibragimova AM2, Khadiyeva Y.D5
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Affiliations:
- Tyumen State Medical Academy, Russian Agency for Health Care
- Therapeutic Health Center, OOO TyumenNIIgiprogaz, Tyumen
- Molecular Genetic Diagnostic Center, Tyumen
- Khanty-Mansiysk District Clinical Hospital
- Issue: Vol 15, No 2 (2010)
- Pages: 34-38
- Section: Articles
- URL: https://rjeid.com/1560-9529/article/view/40478
- DOI: https://doi.org/10.17816/EID40478
- ID: 40478
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Abstract
It was found that in parasitocenoses, pain, astheno-vegetative, dyspeptic, asthenic, and hepatomegalic syndromes were 2.0-3.3 times more frequently observed; the values of ALT, AST, thymol test, and alkaline phosphatase were significantly increased; the level of cholesterol decreased. The immune system exhibited disorganization and depression of humoral and cellular links. A morphological study of liver biopsy specimens by the Knodell scale revealed significantly enhanced hepatocyte destructive processes, alleviated immune-mediated inflammation, and obvious pericellular sclerosis of hepatocytes and sinusoidal capillaries, which substantially impaired the trophics of the liver parenchyma and stimulated apoptosis and necrosis. Virus gene mutations were seen.
The severe course of CH concurrent with opisthorchiasis is attributable to more pronounced destructive processes and hypoxia of hepatocytes. Mutations of "responsible" genes are more frequently responsible for hepatocellular carcinoma.
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About the authors
V G Bychkov
G G Krylov
N A Efimova
Vladimir Vasil'evich Mefod'ev
Email: kravets07@mail.ru
A Kh Sabirov
A M Ibragimova
E D Khadieva
V G Bychkov
Tyumen State Medical Academy, Russian Agency for Health CareTyumen State Medical Academy, Russian Agency for Health Care
G G Krylov
Therapeutic Health Center, OOO TyumenNIIgiprogaz, TyumenTherapeutic Health Center, OOO TyumenNIIgiprogaz, Tyumen
N A Yefimova
Molecular Genetic Diagnostic Center, TyumenMolecular Genetic Diagnostic Center, Tyumen
V V Mefodyev
Tyumen State Medical Academy, Russian Agency for Health CareTyumen State Medical Academy, Russian Agency for Health Care
A Kh Sabirov
Tyumen State Medical Academy, Russian Agency for Health CareTyumen State Medical Academy, Russian Agency for Health Care
A M Ibragimova
Tyumen State Medical Academy, Russian Agency for Health CareTyumen State Medical Academy, Russian Agency for Health Care
Ye D Khadiyeva
Khanty-Mansiysk District Clinical HospitalKhanty-Mansiysk District Clinical Hospital
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