Toxic epidermal necrolysis (Lyell’s syndrome) in a patient with HIV infection

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Abstract


Lyell’s syndrome, or toxic epidermal necrolysis, is a skin disorder characterized by extensive exfoliation of the epidermis. The prognosis for this disease is poor due to damage to the visceral organs, electrolyte disturbances and the risk of infection. The article describes a clinical case of Lyell’s syndrome in an HIV-infected patient who was first prescribed ART in combination with valganciclovir. The diagnosis was made on the basis of characteristic clinical manifestations and the exclusion of another similar pathology. On the background of the therapy, the rash regressed, the areas of damaged skin became epithelialized, and the body temperature returned to normal. A differential diagnosis was made with measles, Stevens-Johnson syndrome, staphylococcal infection. Against the background of the therapy, the patient’s condition was positive.


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About the authors

Darya Popova

Peoples’ Friendship University of Russia (RUDN University); Moscow city clinical Infectious hospital 2 of the Department of health of Moscow city

Author for correspondence.
Email: darinochka_8@mail.ru
ORCID iD: 0000-0002-4056-9192
SPIN-code: 6196-2291

Russian Federation, 15, 8th Sokolinaya Gora street, Moscow

MD

Sergey L. Voznesensky

Peoples’ Friendship University of Russia (RUDN University)

Email: voznesenskiy_sl@pfur.ru
ORCID iD: 0000-0001-5669-1910
SPIN-code: 4487-6744

Russian Federation, Moscow

MD, Cand. Sci. (Med.), Associate Professor

Zinaida A. Soboleva

Moscow city clinical Infectious hospital 2 of the Department of health of Moscow city

Email: oit.2014@mail.ru
ORCID iD: 0000-0002-1629-9348

Russian Federation, Moscow

MD

References

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Supplementary files

Supplementary Files Action
1.
Fig. 1. Bullous changes in the skin with forging erosion.

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2.
Fig. 2. Bullous skin changes with emerging erosion of the lower extremities.

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3.
Fig. 3. Epithelialization of the erosive surface.

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4.
Fig. 4. Epithelialization of the erosive surface of the lower extremities.

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