Search for Monoamine Oxidase Inhibitors among Pyrazoline and Pyrimidine Derivatives and Studying Luminescent Properties of the Obtained Compounds

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Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
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Аннотация

Cyclization of the (E)-3-aryl-1-(4-alkoxyphenyl)prop-2-en-1-ones with phenylhydrazine in an acidic medium leads to the 5-aryl-3-(4-alkoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazoles. Bubbling air through a solution of 5-(4-methoxyphenyl)-1-phenyl-3-(4-ethoxyphenyl)-4,5-dihydro-1H-pyrazole in ethylcellosolve resulted in an oxidation-dehydrogenation product, which characterized as the picrate of the corresponding pyrazole. The reaction of benzamidine and 4-methylbenzamidine hydrochlorides with substituted chalcones in а KOH–ethanol system leads to 2,4-diaryl-6-(4-alkoxyphenyl)pyrimidines. The luminescent and antimonoamine oxidase properties of the resulting systems were studied.

Толық мәтін

Рұқсат жабық

Авторлар туралы

A. Isakhanyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Хат алмасуға жауапты Автор.
Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0000-0002-1713-4908
Армения, Yerevan

N. Hakobyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0000-0002-3095-5938
Армения, Yerevan

Z. Hovasyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0000-0001-6698-7184
Армения, Yerevan

G. Grigoryan

Yerevan State University

Email: gevsgrig@ysu.am
ORCID iD: 0000-0002-0675-735X
Армения, Yerevan

R. Mkhitaryan

Yerevan State University

Email: gevsgrig@ysu.am
ORCID iD: 0009-0009-6277-2747
Армения, Yerevan

D. Yesayan

Yerevan State University

Email: gevsgrig@ysu.am
ORCID iD: 0009-0008-7243-6248
Ресей, Yerevan

A. Grigoryan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0000-0002-3834-3338
Ресей, Yerevan

H. Gasparyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0000-0002-8555-3733
Ресей, Yerevan

Н. Panosyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0000-0001-8311-6276
Ресей, Yerevan

A. Harutyunyan

Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia

Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0000-0003-0641-5453
Ресей, Yerevan

Әдебиет тізімі

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1. JATS XML
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2. Scheme 1

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3. Fig. 1. Electronic absorption spectra of compounds 7-10 (1-4) in DMFA solutions (c = 2·10-5 mol/L)

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4. Fig. 2. Electronic absorption spectra of compounds 11 (1) and 12 (2) in DMFA solutions (c = 5·10-5 mol/L)

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5. Fig. 3. Electronic absorption spectra of compounds 14-17 (1-4) in DMFA solutions (c = 2·10-5 mol/L)

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6. Fig. 4. Electronic absorption spectra of compounds 18-21 (1-4) in DMFA solutions (c = 5·10-5 mol/L)

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7. Fig. 5. Fluorescence spectra of samples 7-10 (1-4) in DMFA solutions (excitation slit width - 5 nm, emission slit width - 5 nm)

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8. Fig. 6. Fluorescence spectra of samples 11 (1) and 12 (2) in DMFA solutions (excitation slit width - 5 nm, emission slit width - 5 nm)

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9. Fig. 7. Fluorescence spectra of samples 14-17 (1-4) in DMFA solutions [excitation slit width - 5 (16 and 17), 10 nm (14 and 15), emission slit width - 5 (16 and 17), 10 nm (14 and 15)]

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10. Fig. 8. Fluorescence spectra of samples 18-21 (1-4) in DMFA solutions (excitation slit width - 10 nm, emission slit width - 10 nm)

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11. Fig. 9. Effect of compounds 7, 9-11, 13 on inhibition of MAO activity at a concentration of 1.0 μmol/mL as a percentage of control (indopan)

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12. Fig. 1

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