Email this article Search for Monoamine Oxidase Inhibitors among Pyrazoline and Pyrimidine Derivatives and Studying Luminescent Properties of the Obtained Compounds
- Authors: Isakhanyan A.U.1, Hakobyan N.Z.1, Hovasyan Z.A.1, Grigoryan G.S.2, Mkhitaryan R.P.2, Yesayan D.L.2, Grigoryan A.S.1, Gasparyan H.V.1, Panosyan Н.A.1, Harutyunyan A.A.1
-
Affiliations:
- Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
- Yerevan State University
- Issue: Vol 94, No 1 (2024)
- Pages: 80-91
- Section: Articles
- URL: https://rjeid.com/0044-460X/article/view/667235
- DOI: https://doi.org/10.31857/S0044460X24010065
- EDN: https://elibrary.ru/HLHZQA
- ID: 667235
Cite item
Open Access
Access granted
Abstract
Cyclization of the (E)-3-aryl-1-(4-alkoxyphenyl)prop-2-en-1-ones with phenylhydrazine in an acidic medium leads to the 5-aryl-3-(4-alkoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazoles. Bubbling air through a solution of 5-(4-methoxyphenyl)-1-phenyl-3-(4-ethoxyphenyl)-4,5-dihydro-1H-pyrazole in ethylcellosolve resulted in an oxidation-dehydrogenation product, which characterized as the picrate of the corresponding pyrazole. The reaction of benzamidine and 4-methylbenzamidine hydrochlorides with substituted chalcones in а KOH–ethanol system leads to 2,4-diaryl-6-(4-alkoxyphenyl)pyrimidines. The luminescent and antimonoamine oxidase properties of the resulting systems were studied.
Full Text
About the authors
A. U. Isakhanyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Author for correspondence.
Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0000-0002-1713-4908
Armenia, Yerevan
N. Z. Hakobyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0000-0002-3095-5938
Armenia, Yerevan
Z. A. Hovasyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0000-0001-6698-7184
Armenia, Yerevan
G. S. Grigoryan
Yerevan State University
Email: gevsgrig@ysu.am
ORCID iD: 0000-0002-0675-735X
Armenia, Yerevan
R. P. Mkhitaryan
Yerevan State University
Email: gevsgrig@ysu.am
ORCID iD: 0009-0009-6277-2747
Armenia, Yerevan
D. L. Yesayan
Yerevan State University
Email: gevsgrig@ysu.am
ORCID iD: 0009-0008-7243-6248
Russian Federation, Yerevan
A. S. Grigoryan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0000-0002-3834-3338
Russian Federation, Yerevan
H. V. Gasparyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0000-0002-8555-3733
Russian Federation, Yerevan
Н. A. Panosyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0000-0001-8311-6276
Russian Federation, Yerevan
A. A. Harutyunyan
Scientific and Technological Center of Organic and Pharmaceutical Chemistry of the National Academy of Sciences of the Republic of Armenia
Email: anush.isakhanyan.51@mail.ru
ORCID iD: 0000-0003-0641-5453
Russian Federation, Yerevan
References
- Чиряпкин А.С. // Juvenis Scientia. 2022. Т. 8. № 5. С. 16. doi: 10.32415/jscientia_2022_8, 5,_16-30
- Varghese B., Al-Busafi S.N., Suliman F.O., Al-Kindy S.M.Z. // RSC Adv. 2017. Vol. 7. N 74. P. 46999. doi: 10.1039/c7ra08939b
- Kumar S., Bawa S., Drabu S., Kumar R., Gupta H. // Recent Pat. Antiinfect. Drug Discov. 2009. Vol. 4. N 3. P. 154. doi: 10.2174/157489109789318569
- Nehra B., Rulhania S., Jaswal S., Kumar B., Singh G., Monga V. // Eur. J. Med. Chem. 2020. Vol. 205. P. 112666. doi: 10.1016/j.ejmech.2020.112666
- Matiadis D., Sagnou M. // Int. J. Mol. Sci. 2020. Vol. 21. N 15. P. 5507. doi: 10.3390/ijms21155507
- Deng H., Yu Z.Y., Shi G.Y., Chen M.J., Tao K., Hou T.P. // Chem. Biol. Drug Des. 2012. Vol. 79. N 3. P. 279. doi: 10.1111/j.1747-0285.2011.01308.x
- Машковский М.Д. Лекарственные средства. М.: Новая волна, 2010. С. 851.
- Guglielmi P., Carradori S., Poli G., Secci D., Cirilli R., Rotondi G., Chimenti P., Petzer A., Petzer J.P. // Molecules. 2019. Vol. 24. N 3. Р. 484. doi: 10.3390/molecules24030484
- Исаханян А.У., Акопян Н.З., Овасян З.А., Григорян Г.С., Мхитарян Р.П., Аракелян А.Г., Сафарян А.С., Мурадян Р.Е., Паносян Г.А., Арутюнян А.А. // ЖОХ. 2023. Т. 93. № 9. С. 1335; Isakhanyan A.U., Hakobyan N.Z., Hovasyan Z.A., Grigoryan G.S., Mkhitaryan R.P., Aracelyan H.G., Safaryan A.S., Muradyan R.E., Panosyan Н.A., Harutyunyan A.A. // Russ. J. Gen. Chem. 2023. Vol. 93. N 9. P. 2210. doi: 10.1134/S1070363223090037
- Lakowicz J.R. Principles of Fluorescence Spectroscopy. New York: Springer, 2006. P. 954. doi: 10.1007/978-0-387-46312-4
- Brouwer A.M. // Pure Appl. Chem. 2011. Vol. 83. N 12. P. 2213. doi: 10.1351/PAC-REP-10-09-31
- Shivananda M.K., Holla B.S. // J. Chem. Pharm. Res. 2017. Vol. 9. N 6. P. 1.
Supplementary files
