New Schiff Base Derived Organotin (IV) Complexes: Synthesis, Characterization, In vitro and In silico Biological Studies

详细

Aims:The creation and testing of new Schiff base-based antibacterial organotin (IV) complexes were the objectives of this investigation.

Background:Due to developed resistance, antibiotics that were once often used to treat microor-ganisms are no longer effective against them. It is thought that organotin compounds synthesized from Schiff bases have significant pharmacological effectiveness and work well as antibacterial agents.

Methods:Thiocarbohydrazide and dehydroacetic acid were condensed to create the Schiff base, followed by processing with dialkyltin(IV)dichloride to synthesize the final product. Modern an-alytical techniques were used to clarify the compounds' probable structural details. The crystalline nature of the produced compounds was tested using PXRD.

Results:All of the compounds were thermally stable up to 300°C. All of the synthesized com-plexes showed potent antibacterial activity in the range of 250 to 400 µg/ml. Furthermore, the computational biology research showed that, in contrast to ligands, which had a binding energy of -7.3 to -7.4 kcal/mol, complexes interacted well with dihydropteroate synthase and DNA gy-rase.

Conclusion:The current study offered a unique technique for synthesizing diorganotin(IV) de-rivatives of N-substituted Schiff bases that are physiologically active. The results show that the chemicals created are promising antibacterial mediators against diseases that affect humans in the modern world. It might also open the door to future studies on drug-resistant microorganisms that could have biological uses.