Why do some Children Get Sick with Recurrent Respiratory Infections?
- Authors: Cardinale F.1, La Torre F.2, Tricarico L.3, Verriello G.2, Mastrorilli C.3
-
Affiliations:
- Pediatric and Emergency Unit, AOU Consorziale Policlinic of Bari, Giovanni XXIII Pediatric Hospita
- Pediatric and Emergency Unit,, AOU Consorziale Policlinic of Bari, Giovanni XXIII Pediatric Hospital
- Pediatric and Emergency Unit, AOU Consorziale Policlinic of Bari, Giovanni XXIII Pediatric Hospital
- Issue: Vol 20, No 3 (2024)
- Pages: 203-215
- Section: Medicine
- URL: https://rjeid.com/1573-3963/article/view/645529
- DOI: https://doi.org/10.2174/1573396320666230912103056
- ID: 645529
Cite item
Full Text
Abstract
Respiratory tract infections (RTI) represent a frequent condition, particularly among preschool children, with an important burden on the affected children and their families. It has been estimated that recurrent RTIs affect up to 25% of children during the first 4 years of life. Th- ese infections are mainly caused by viruses and are generally self-limiting. Social and environmen- tal factors have been studied in determining the incidence of recurrent RTIs and the mostly recog- nized are precocious day care attendance, tobacco exposure and pollution. Primary immune de- fects, local anatomical factors, and genetic disorders such as primary ciliary dyskinesia or cystic fi- brosis, may be also involved in recurrent RTIs of a subgroup of children, typically characterized by more severe and chronic symptoms. However, there is increasing awareness that RTIs have a com- plex pathophysiology and that some underrecognized factors, including genetic susceptibility to in- fections, low levels of some micronutrients, and respiratory microbiota might shape the probability for the child to develop RTIs. The sum (i.e. the number) of these factors may help in explaining why some children get sick for RTIs whilst other not. In some children iatrogenic factors, includ- ing improper use of antibiotics and NSAIDS or glucocorticoids might also aggravate this condi- tion, further weakening the host's immune response and the possibly of establishing a "vicious cir- cle". The present review aims to focus on several possible factors involved in influencing RTIs and to propose a unifying hypothesis on pathophysiological mechanisms of unexplained recurrent RTIs in children.
About the authors
Fabio Cardinale
Pediatric and Emergency Unit, AOU Consorziale Policlinic of Bari, Giovanni XXIII Pediatric Hospita
Email: info@benthamscience.net
Francesco La Torre
Pediatric and Emergency Unit,, AOU Consorziale Policlinic of Bari, Giovanni XXIII Pediatric Hospital
Email: info@benthamscience.net
Lucia Tricarico
Pediatric and Emergency Unit, AOU Consorziale Policlinic of Bari, Giovanni XXIII Pediatric Hospital
Email: info@benthamscience.net
Giuseppe Verriello
Pediatric and Emergency Unit,, AOU Consorziale Policlinic of Bari, Giovanni XXIII Pediatric Hospital
Email: info@benthamscience.net
Carla Mastrorilli
Pediatric and Emergency Unit, AOU Consorziale Policlinic of Bari, Giovanni XXIII Pediatric Hospital
Author for correspondence.
Email: info@benthamscience.net
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