Interventions for Enuresis in Children and Adolescents: An Overview of Systematic Reviews


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Background:enuresis is an involuntary and intermittent loss of urine during sleep and its treatment can be done by pharmacological and non-pharmacological strategies.

Objective:to conduct an overview to carry out a survey of the systematic reviews about treatment options for children/adolescents with enuresis.

Methods:Databases used were Cochrane Library, PROSPERO, MEDLINE/PubMed, EMBASE, LILACS/BVS, PEDro, SciELO and Google Scholar. Any type of intervention for the treatment of enuresis in children/adolescents were selected by two independent researchers. Data extraction was done by two independent researchers. The risk of bias was assessed using Risk of Bias in Systematic Reviews (ROBIS) and A MeaSurement Tool to Assess Systematic Reviews (AMSTAR-2).

Results:seven systematic reviews were included. According to ROBIS, three reviews had a low risk of bias, while the others had a high risk of bias. Based on AMSTAR-2, four systematic reviews were of moderate quality, two were low quality and one was critically low quality.

Conclusion:there is moderate confidence that the use of desmopressin plus an anticholinergic agent increases the chance of complete response compared to desmopressin alone. Neurostimulation may increase the risk of responses ≥50% and ≥90% compared to the control group. Likewise, it appears that electrical stimulation is superior to placebo about the chance of response ≥50%. In addition, there is the clinical relevance in reducing enuresis episodes per week when neurostimulation is used compared to control groups.

Sobre autores

Eduarda Correia Moretti

Department of Anatomy, Federal University of Pernambuco, Child and Adolescent Health,, Federal University of Per-nambuco -

Autor responsável pela correspondência
Email: info@benthamscience.net

Ivson da Silva

Department of Morphology, Federal University of Paraiba

Email: info@benthamscience.net

Alessandra Boaviagem

Department of Physiotherapy, Federal University of Pernambuco

Email: info@benthamscience.net

Anna de Lima

Department of Animal Morphology and Physiology, Federal Rural University of Pernambuco

Email: info@benthamscience.net

Andrea Lemos

Department of Physical Therapy, Federal University of Pernambuco

Email: info@benthamscience.net

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