Redox Modulation of Meniere Disease by Coriolus versicolor Treatment, a Nutritional Mushroom Approach with Neuroprotective Potential


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Abstract

Background:Meniere's disease (MD) is a cochlear neurodegenerative disease. Hearing loss appears to be triggered by oxidative stress in the ganglion neurons of the inner ear.

Objective:Here, we confirm the variation of markers of oxidative stress and inflammation in patients with Meniere and hypothesize that chronic treatment with Coriolus mushroom helps in the response to oxidative stress and acts on α-synuclein and on NF-kB-mediated inflammatory processes.

Methods:Markers of oxidative stress and inflammation were evaluated in MD patients with or without Coriolus treatment for 3 or 6 months.

Results:MD patients had a small increase in Nrf2, HO-1, γ-GC, Hsp70, Trx and sirtuin-1, which were further increased by Coriolus treatment, especially after 6 months. Increased markers of oxidative damage, such as protein carbonyls, HNE, and ultraweak chemiluminescence, associated with a decrease in plasma GSH/GSSG ratio, were also observed in lymphocytes from MD patients. These parameters were restored to values similar to the baseline in patients treated with Coriolus for both 3 and 6 months. Furthermore, treated MD subjects showed decreased expression of α-synuclein, GFAP and Iba-1 proteins and modulation of the NF-kB pathway, which were impaired in MD patients. These changes were greatest in subjects taking supplements for 6 months.

Conclusions:Our study suggests MD as a model of cochlear neurodegenerative disease for the identification of potent inducers of the Nrf2-vitagene pathway, able to reduce the deleterious consequences associated with neurodegenerative damage, probably by indirectly acting on a-synuclein expression and on inflammatory processes NF-kB-mediated.

About the authors

Rosanna Paola

Department of Veterinary Science, University of Messina

Email: info@benthamscience.net

Rosalba Siracusa

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina

Email: info@benthamscience.net

Roberta Fusco

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina

Email: info@benthamscience.net

Marialaura Ontario

Department of Biomedical and Biotechnological Sciences; Department of Medical, Surgical Advanced Technologies "G.F. Ingrassia", University of Catania

Email: info@benthamscience.net

Gaetano Cammilleri

Food Department, Istituto Zooprofilattico Sperimentale della Sicilia

Email: info@benthamscience.net

Licia Pantano

Food Department, Istituto Zooprofilattico Sperimentale della Sicilia

Email: info@benthamscience.net

Maria Scuto

Department of Biomedical and Biotechnological Sciences; Department of Medical, Surgical Advanced Technologies "G.F. Ingrassia", University of Catania

Email: info@benthamscience.net

Mario Tomasello

Department of Biomedical and Biotechnological Sciences; Department of Medical, Surgical Advanced Technologies "G.F. Ingrassia",, University of Catania

Email: info@benthamscience.net

Sestina Spanò

Department of Biomedical and Biotechnological Sciences; Department of Medical, Surgical Advanced Technologies "G.F. Ingrassia",, University of Catania

Email: info@benthamscience.net

Angela Salinaro

Department of Biomedical and Biotechnological Sciences; Department of Medical, Surgical Advanced Technologies "G.F. Ingrassia", University of Catania

Email: info@benthamscience.net

Ali Abdelhameed

Department of Pharmaceutical Chemistr, College of Pharmacy, King Saud University

Email: info@benthamscience.net

Vincenzo Ferrantelli

Food Department, Istituto Zooprofilattico Sperimentale della Sicilia

Email: info@benthamscience.net

Antonio Arcidiacono

Department of Biomedical and Biotechnological Sciences; Department of Medical, Surgical Advanced Technologies "G.F. Ingrassia", University of Catania

Email: info@benthamscience.net

Tilman Fritsch

, NAM Institute

Email: info@benthamscience.net

Gabriella Lupo

Department of Biomedical and Biotechnological Sciences; Department of Medical, Surgical Advanced Technologies "G.F. Ingrassia",, University of Catania

Author for correspondence.
Email: info@benthamscience.net

Anna Signorile

Department of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro

Author for correspondence.
Email: info@benthamscience.net

Luigi Maiolino

Department of Biomedical and Biotechnological Sciences; Department of Medical, Surgical Advanced Technologies "G.F. Ingrassia",, University of Catania

Email: info@benthamscience.net

Salvatore Cuzzocrea

Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messin

Email: info@benthamscience.net

Vittorio Calabrese

Department of Biomedical and Biotechnological Sciences; Department of Medical, Surgical Advanced Technologies "G.F. Ingrassia", University of Catania

Email: info@benthamscience.net

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