Effect of Nigella sativa Intake on Oxidative Stress and Inflammation in Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-analysis of Randomized Controlled Trials


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Background:Several studies have shown that the intake of N. sativa has a beneficial effect on metabolic syndrome and related disorders. In this meta-analysis, our primary objective was to assess the impact of Nigella sativa consumption on inflammation and oxidative stress biomarkers among individuals diagnosed with metabolic syndrome and its associated conditions.

Methods:Our search was conducted on prominent online databases such as Web of Science, Scopus, PubMed, and EMBASE, utilizing relevant keywords until August 2023.

Results:This meta-analysis was performed on 16 RCTs comprising 1033 participants. Our results showed that intake of Nigella sativa significantly decreased CRP (SMD: -0.60; (95% CI: from -0.96 to -0.23); P = 0.00), TNF-α (SMD: -0.53; (95% CI: from -0.74 to -0.53); P = 0.00); IL-6 (SMD: -0.54 ; (95% CI: from -1.01 to -0.07); P = 0.02), and MDA: (SMD: -1.28; (95% CI: from -2.11 to -0.46); P = 0.00) levels. In addition, SOD: (SMD: 1.35; (95% CI, from 0.77 to 1.93); P = 0.00) and TAC (SMD: 2.82; (95% CI, from 0.55 to 5.084); P = 0.01) levels significantly increased in the intervention group compared to the placebo group.

Conclusion:Our results showed that THE consumption of N. sativa could be associated with improved oxidative stress and inflammation in patients with metabolic syndrome and related disorders.

Sobre autores

Hossein Hosseini

Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Farideh Ghavidel

Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Mahdieh Aliyari

Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Seyed Hashemy

Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Tannaz Jamialahmadi

International UNESCO Center for Health-Related Basic Sciences and Human Nutrition, Mashhad University of Medical Sciences

Email: info@benthamscience.net

Amirhossein Sahebkar

Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences

Autor responsável pela correspondência
Email: info@benthamscience.net

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