Progression in the Relationship between Exosome Production and Atherosclerosis


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Abstract

Atherosclerosis (AS) is the leading cause of cardiovascular disease, causing a major burden on patients as well as families and society. Exosomes generally refer to various lipid bilayer microvesicles originating from different cells that deliver various bioactive molecules to the recipient cells, exerting biological effects in cellular communication and thereby changing the internal environment of the body. The mechanisms of correlation between exosomes and the disease process of atherosclerosis have been recently clarified. Exosomes are rich in nucleic acid molecules and proteins. For example, the exosome miRNAs reportedly play important roles in the progression of atherosclerotic diseases. In this review, we focus on the composition of exosomes, the mechanism of their biogenesis and release, and the commonly used methods for exosome extraction. By summarizing the latest research progress on exosomes and atherosclerosis, we can explore the advances in the roles of exosomes in atherosclerosis to provide new ideas and targets for atherosclerosis prevention, diagnosis, and treatment.

About the authors

Yi Yang

Clinical Medical School, Weifang Medical University

Email: info@benthamscience.net

Jinxi Luo

Clinical Medical School, Weifang Medical University

Email: info@benthamscience.net

Yunan Kang

College of Anesthesiology, Weifang Medical University

Email: info@benthamscience.net

Wenqian Wu

Clinical Medical School, Weifang Medical University

Email: info@benthamscience.net

Yajie Lu

Clinical Medical School, Weifang Medical University

Email: info@benthamscience.net

Jie Fu

School of Basic Medicine Sciences, Weifang Medical University

Email: info@benthamscience.net

Xiaoyun Zhang

School of Basic Medial Medicine, Weifang Medical University

Email: info@benthamscience.net

Min Cheng

Clinical Medical School, Weifang Medical University

Author for correspondence.
Email: info@benthamscience.net

Xiaodong Cui

School of Basic Medicine Sciences, Weifang Medical University

Author for correspondence.
Email: info@benthamscience.net

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