BAO-Ag-NPs as Promising Suppressor of ET-1/ICAM-1/VCAM-1 Signaling Pathway in ISO-induced AMI in Rats

  • Authors: Mosaad Y.1, Ateyya H.2, Hussein M.3, Moro A.4, Abdel-Wahab E.5, El-Ella A.6, Nassar Z.7
  • Affiliations:
    1. Department of Pharmacy, Practice & Clinical Pharmacy, Faculty of Pharmacy,, Future University
    2. Department of Medical Pharmacology, Faculty of Medicine,, Cairo University
    3. Department of Biochemistry, Faculty of Applied Medical Science, October 6th University
    4. Department of Biophysics, Faculty of Applied Health Sciences,, October 6 University
    5. Department of Biophysics, Faculty of Applied Health Sciences, October 6 University,
    6. Department of Measurements, Photochemistry and Agriculture Applications, National Institute of Laser Enhanced Science,, Cairo University
    7. Medical Laboratory Department, Faculty of Applied Medical Sciences,, October 6 University
  • Issue: Vol 25, No 6 (2024)
  • Pages: 772-786
  • Section: Biotechnology
  • URL: https://rjeid.com/1389-2010/article/view/644889
  • DOI: https://doi.org/10.2174/0113892010256434231010062233
  • ID: 644889

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Full Text

Abstract

Objectives:Acute myocardial infarction (AMI) is the most prevalent cause of myocardial fibrosis and the leading cause of mortality from cardiovascular disease. The goal of this work was to synthesize Balanites aegyptiaca oil-silver nanoparticles (BAO-Ag-NPs) and evaluate their cardioprotective effect against ISO-induced myocardial infarction in rats, as well as their mechanism.

Materials and Methods:BAO was isolated, and the unsaturated fatty acids were estimated. BAO-Ag-NPs was prepared, LD50 was calculated to evaluate its cardioprotective activity against ISO (85 mg/kg)-induced AMI. Different doses of BAO-Ag-NPs (1/50 LD50; 46.6 mg/kg.b.w and 1/20 LD50; 116.5 mg) were received to the rats.

Results:The total fatty acids and unsaturated fatty acids generated by BAO were 909.63 and 653.47 mg/100 g oil, respectively. Oleic acid methyl ester, 9-octadecenoic acid methyl ester, and 9, 12-Octadecadienoic acid methyl ester were the predominant ingredients, with concentrations of 107.6, 243.42, and 256.77 mg/100 g oil, respectively. According to TEM and DLS examinations, BAO-Ag-NPs have a size of 38.20 ± 2.5 nm and a negative zeta potential of -19.82 ± 0.30 mV, respectively. The LD50 of synthesized BAO-Ag-NPs is 2330 mg. On the other hand, BAOAg- NPs reduce myocardial necrosis by lowering increased BNP, cTnI, CK-MB, TC, TG, MDA, MMP2, TGF-β1, PGE2, and IL-6 levels. Furthermore, BAO-Ag-NPs inhibit the expression of ET-1, ICAM-1, and VCAM-1 genes as well as enhance HDL-C, CAT, and GSH levels when compared to the ISO-treated group of rats. Histopathological findings suggested that BAO-Ag- NPs enhance cardiac function by increasing posterior wall thickness in heart tissues.

Conclusion:BAO-Ag-NPs protect against AMI in vivo by regulating inflammation, excessive autophagy, and oxidative stress, as well as lowering apoptosis via suppression of the ET-1, ICAM-1, and VCAM-1 signaling pathways.

About the authors

Yasser Mosaad

Department of Pharmacy, Practice & Clinical Pharmacy, Faculty of Pharmacy,, Future University

Email: info@benthamscience.net

Hayam Ateyya

Department of Medical Pharmacology, Faculty of Medicine,, Cairo University

Email: info@benthamscience.net

Mohammed Hussein

Department of Biochemistry, Faculty of Applied Medical Science, October 6th University

Email: info@benthamscience.net

Ahmed Moro

Department of Biophysics, Faculty of Applied Health Sciences,, October 6 University

Email: info@benthamscience.net

Ebtsam Abdel-Wahab

Department of Biophysics, Faculty of Applied Health Sciences, October 6 University,

Email: info@benthamscience.net

Amr El-Ella

Department of Measurements, Photochemistry and Agriculture Applications, National Institute of Laser Enhanced Science,, Cairo University

Email: info@benthamscience.net

Zahraa Nassar

Medical Laboratory Department, Faculty of Applied Medical Sciences,, October 6 University

Author for correspondence.
Email: info@benthamscience.net

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