Cubosomes: An Emerging and Promising Drug Delivery System for Enhancing Cancer Therapy


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Abstract

Cancer and other diseases can be treated with cubosomes, which are lyotropic nonlamellar liquid crystalline nanoparticles (LCNs). These cubosomes can potentially be a highly versatile carrier with theranostic efficacy, as they can be ingested, applied topically, or injected intravenously. Recent years have seen substantial progress in the synthesis, characterization, regulation of drug release patterns, and target selectivity of loaded anticancer bioactive compounds. However, its use in clinical settings has been slow and necessitates additional proof. Recent progress and roadblocks in using cubosomes as a nanotechnological intervention against various cancers are highlighted. In the last few decades, advances in biomedical nanotechnology have allowed for the development of \"smart\" drug delivery devices that can adapt to external stimuli. By improving therapeutic targeting efficacy and lowering the negative effects of payloads, these well-defined nanoplatforms can potentially promote patient compliance in response to specific stimuli. Liposomes and niosomes, two other well-known vesicular systems, share a lipid basis with cubosomes. Possible applications include a novel medication delivery system for hydrophilic, lipophilic, and amphiphilic drugs. We evaluate the literature on cubosomes, emphasizing their potential use in tumor-targeted drug delivery applications and critiquing existing explanations for cubosome self-assembly, composition, and production. As cubosome dispersion has bioadhesive and compatible features, numerous drug delivery applications, including oral, ocular, and transdermal, are also discussed in this review.

About the authors

Smita Singh

SRM Modinagar College of Pharmacy, SRM Institute of Science and Technology

Email: info@benthamscience.net

Kapil Sachan

KIET School of Pharmacy, KIET Group of Institutions

Email: info@benthamscience.net

Suryakant Verma

School of Pharmacy, Bharat Institute of Technology

Email: info@benthamscience.net

Nidhi Singh

, Sunder Deep Pharmacy College

Email: info@benthamscience.net

Pranjal Singh

SRM Modinagar College of Pharmacy, SRM Institute of Science and Technology

Author for correspondence.
Email: info@benthamscience.net

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