Systematic Review on Herbal Preparations for Controlling Visceral Hypersensitivity in Functional Gastrointestinal Disorders
- Авторлар: Lashgari N.1, Momeni Roudsari N.1, Momtaz S.2, Niazi Shahraki F.1, Zandi N.3, Pazoki B.4, Farzaei M.5, Ghasemi M.6, Abdollahi M.7, Abdolghaffari A.H.8
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Мекемелер:
- Department of Toxicology & Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University Pharmaceutical Sciences Branch
- Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR
- Department of Pharmacology,, Tehran University of Medical Sciences
- Department of Pharmacology, Tehran University of Medical Sciences
- Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences
- Department of Neurology, University of Massachusetts School of Medicine
- Toxicology and Diseases Group (TDG), Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), and Faculty of Pharmacy, Tehran University of Medical Sciences
- Department of Toxicology & Pharmacology, Faculty of Pharmacy,, Islamic Azad University Pharmaceutical Sciences Branch
- Шығарылым: Том 25, № 13 (2024)
- Беттер: 1632-1650
- Бөлім: Biotechnology
- URL: https://rjeid.com/1389-2010/article/view/644504
- DOI: https://doi.org/10.2174/0113892010261502231102040149
- ID: 644504
Дәйексөз келтіру
Толық мәтін
Аннотация
Background:Visceral hypersensitivity (VH) is an overreaction of the gastrointestinal (GI) tract to various stimuli and is characterized by hyperalgesia and/or allodynia. VH contributes to the etiology of many GI dysfunctions, particularly irritable bowel syndrome (IBS). Although the exact mechanisms underlying VH are yet to be found, inflammation and oxidative stress, psychosocial factors, and sensorimotor alterations may play significant roles in it.
Objective:In this review, we provide an overview of VH and its pathophysiological function in GI disorders. Adverse effects of synthetic drugs may make herbal agents a good candidate for pain management. Therefore, in this review, we will discuss the efficacy of herbal agents in the management of VH with a focus on their anti-inflammatory and antioxidant potentials.
Methods:Data were extracted from clinical and animal studies published in English between 2004 and June, 2020, which were collected from PubMed, Google Scholar, Scopus, and Cochrane Library.
Results:Overall, Radix, Melissia, Glycyrrhizae, Mentha, and Liquorice were the most efficient herbals for VH management in IBS and dyspepsia, predominantly through modulation of the mRNA expression of transient receptor potential vanilloid type-1 (TRPV1) and suppression of 5- hydroxytryptamine 3 (5-HT3) or the serotonin receptors.
Conclusion:Considering the positive effects of herbal formulations in VH management, further research on novel herbal and/or herbal/chemical preparations is warranted.
Авторлар туралы
Naser-Aldin Lashgari
Department of Toxicology & Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University Pharmaceutical Sciences Branch
Email: info@benthamscience.net
Nazanin Momeni Roudsari
Department of Toxicology & Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University Pharmaceutical Sciences Branch
Email: info@benthamscience.net
Saeideh Momtaz
Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR
Email: info@benthamscience.net
Faezeh Niazi Shahraki
Department of Toxicology & Pharmacology, Faculty of Pharmacy, Tehran Medical Sciences, Islamic Azad University Pharmaceutical Sciences Branch
Email: info@benthamscience.net
Nadia Zandi
Department of Pharmacology,, Tehran University of Medical Sciences
Email: info@benthamscience.net
Benyamin Pazoki
Department of Pharmacology, Tehran University of Medical Sciences
Email: info@benthamscience.net
Mohammad Farzaei
Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences
Хат алмасуға жауапты Автор.
Email: info@benthamscience.net
Mehdi Ghasemi
Department of Neurology, University of Massachusetts School of Medicine
Email: info@benthamscience.net
Mohammad Abdollahi
Toxicology and Diseases Group (TDG), Pharmaceutical Sciences Research Center (PSRC), The Institute of Pharmaceutical Sciences (TIPS), and Faculty of Pharmacy, Tehran University of Medical Sciences
Email: info@benthamscience.net
Amir Abdolghaffari
Department of Toxicology & Pharmacology, Faculty of Pharmacy,, Islamic Azad University Pharmaceutical Sciences Branch
Хат алмасуға жауапты Автор.
Email: info@benthamscience.net
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