The Functions and Mechanisms of Long Non-coding RNA SNHGs in Gastric Cancer


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Abstract

:Gastric cancer (GC) is one of the most common malignancies worldwide. Despite significant advancements in surgical and adjuvant treatments, patient prognosis remains unsatisfactory. Long non-coding RNAs (lncRNAs) are a class of RNA molecules that lack protein-coding capacity but can engage in the malignant biological behaviors of tumors through various mechanisms. Among them, small nucleolar host genes (SNHGs) represent a subgroup of lncRNAs. Studies have revealed their involvement not only in gastric cancer cell proliferation, invasion, migration, epithelial- mesenchymal transition (EMT), and apoptosis but also in chemotherapy resistance and tumor stemness. This review comprehensively summarizes the biological functions, molecular mechanisms, and clinical significance of SNHGs in gastric cancer. It provides novel insights into potential biomarkers and therapeutic targets for the exploration of gastric cancer.

About the authors

Songhua Liu

Gansu Provincial Hospital, The First Clinical Medical College of Gansu University of Chinese Medicine

Email: info@benthamscience.net

Yao Rong

Gansu Provincial Hospital, The First Clinical Medical College of Gansu University of Chinese Medicine

Email: info@benthamscience.net

Mingzheng Tang

Gansu Provincial Hospital, The First Clinical Medical College of Gansu University of Chinese Medicine

Email: info@benthamscience.net

Qiqi Zhao

College of Clinical Medicine, Ningxia Medical University

Email: info@benthamscience.net

Chunyan Li

, The First Clinical Medical School of Lanzhou University

Email: info@benthamscience.net

Wenbin Gao

Gansu Provincial Hospital, The First Clinical Medical College of Gansu University of Chinese Medicine

Email: info@benthamscience.net

Xiaojun Yang

, GThe First Clinical Medical School of Lanzhou University

Author for correspondence.
Email: info@benthamscience.net

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