The Role of Innate Immunity in Osteoarthritis and the Connotation of "Immune-joint" Axis: A Narrative Review


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Osteoarthritis (OA) is a degenerative disease that results in constriction of the joint space due to the gradual deterioration of cartilage, alterations in subchondral bone, and synovial membrane. Recently, scientists have found that OA involves lesions in the whole joint, in addition to joint wear and tear and cartilage damage. Osteoarthritis is often accompanied by a subclinical form of synovitis, which is a chronic, relatively low-grade inflammatory response mainly mediated by the innate immune system. The "immune-joint" axis refers to an interaction of an innate immune response with joint inflammation and the whole joint range. Previous studies have underestimated the role of the immune-joint axis in OA, and there is no related research. For this reason, this review aimed to evaluate the existing evidence on the influence of innate immune mechanisms on the pathogenesis of OA. The innate immune system is the body's first line of defense. When the innate immune system is triggered, it instantly activates the downstream inflammatory signal pathway, causing an inflammatory response, while also promoting immune cells to invade joint synovial tissue and accelerate the progression of OA. We have proposed the concept of the \"immune-joint\" axis and explored it from two aspects of Traditional Chinese Medicine (TCM) theory and modern medical research, such as the innate immunity and OA, macrophages and OA, complement and OA, and other cells and OA, to enrich the scientific connotation of the \"immune-joint\" axis.

作者简介

Gaoyan Kuang

Department of Orthopedic Surgery, The First Hospital of Hunan University of Chinese Medicine

Email: info@benthamscience.net

Xuyi Tan

Department of Orthopedic Surgery, Affiliated Hospital of Hunan Academy of Chinese Medical Science

Email: info@benthamscience.net

Xin Liu

Department of Orthopedic Surgery, The First Hospital of Hunan University of Chinese Medicine

Email: info@benthamscience.net

Naping Li

Department of Orthopedic Surgery, The First Hospital of Hunan University of Chinese Medicine

Email: info@benthamscience.net

Nanxing Yi

, Hunan University of Chinese Medicine

Email: info@benthamscience.net

Yilin Mi

, Hunan University of Chinese Medicine

Email: info@benthamscience.net

Qiyun Shi

, Hunan University of Chinese Medicine

Email: info@benthamscience.net

Fan Zeng

, Hunan University of Chinese Medicine

Email: info@benthamscience.net

Xinjun Xie

Department of Orthopedic Surgery, The First Hospital of Hunan University of Chinese Medicine

编辑信件的主要联系方式.
Email: info@benthamscience.net

Min Lu

Department of Orthopedic Surgery, The First Hospital of Hunan University of Chinese Medicine

编辑信件的主要联系方式.
Email: info@benthamscience.net

Xiaotong Xu

Department of Orthopedic Surgery, The First Hospital of Hunan University of Chinese Medicine

编辑信件的主要联系方式.
Email: info@benthamscience.net

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