Protective Effects of the Aqueous Extract of Malva sylvestris Plant against the Lethality and Histopathological Damage in Experimental Envenoming of Hemiscorpius lepturus Venom in Balb/c Mice


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Abstract

Introduction:Hemiscorpius lepturus envenomation is a serious health problem in the southern provinces of Iran. The antiserum produced in Iran to counteract this scorpion venom is not entirely effective due to the risk of anaphylactic shock and other adverse effects.

Methods:Therefore, more efficient alternatives to treat patients deserve attention, and plants are extensively good candidates to be studied. This study aimed to assess the potential of the aqueous fraction of Malva sylvestris in inhibiting the toxic effects of H. lepturus venom. Injection of sub-lethal dose of H. lepturus venom leads to severe tissue damage in vital organs including the kidney, liver, heart and intestine, after 24 hours.

Results:By injecting 80 mg of the aqueous extract of M. sylvestris into the peritoneum helped treat the damaged tissues caused by H. lepturus venom in mice.

Conclusion:Thus, Malva sylvestris could serve as an alternative treatment for scorpion sting envenomation and may be used as a drug to neutralize relevant toxic effects in patients stung by H. lepturus.

About the authors

Sayyed Ahmadi

Student Research Committee, Mazandaran University of Medical Sciences

Email: info@benthamscience.net

Mohammad Yousofpour

Department of Persian Medicine, Faculty of Medicine, Mazandaran University of Medical Sciences

Author for correspondence.
Email: info@benthamscience.net

Mohammad Kamalinejad

Department of Pharmacognosy, School of Pharmacy, Shahid Beheshti University of Medical Sciences

Email: info@benthamscience.net

Arman Otroshi

Isfahan Clinical Toxicology Research Center,, Isfahan University of Medical Sciences

Email: info@benthamscience.net

Fereshteh Amiri

Department of Anatomy, Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences

Email: info@benthamscience.net

Abbas Alipour

Community Medicine Department, Medical Faculty, Mazandaran University of Medical Sciences

Email: info@benthamscience.net

Mohammad Zareinejad

Venom and Biotherapeutics Molecules Lab., Medical Biotechnology Department,, Biotechnology Research Center, Pasteur Institute of Iran

Email: info@benthamscience.net

Delavar Shahbazzadeh

Venom and Biotherapeutics Molecules Lab., Medical Biotechnology Department,, Biotechnology Research Center, Pasteur Institute of Iran

Author for correspondence.
Email: info@benthamscience.net

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