The Relationship of Inflammation with Energetic Metabolism and Mitochondrial Dysfunction in Autistic Spectrum Disorders

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Abstract

According to the totality of inflammatory markers, a cluster of patients with autism spectrum disorders (ASD) and high levels of inflammation (N = 35, 70%) was identified. Discriminant analysis showed that the catabolite of the kynurenine pathway, which makes the greatest contribution to the pathogenesis of RAS, is quinolic acid. Dysregulation of energy metabolism has been revealed, including both the main pathways of catabolism (glycolysis, the Krebs cycle) and alternative pathways (beta-oxidation, ketogenesis, branched amino acid metabolism) with impaired mitochondrial function (meglutol) in patients with ASD. Correlations have been revealed for a number of energy exchange metabolites with indicators of inflammation. Inflammation in ASD is associated with dysregulation of energy metabolism and mitochondrial dysfunction. These data can serve as the basis for new treatment protocols, including anti-inflammatory therapy, metabolic correction, and restoration of mitochondrial function.

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About the authors

V. O. Generalov

Medical Center “PlanetaMed”

Email: klushnik2004@mail.ru
Russian Federation, Moscow

T. P. Klushnik

Medical Center “PlanetaMed”

Author for correspondence.
Email: klushnik2004@mail.ru
Korea, Republic of, Moscow

T. E. Obodzinskaya

Medical Center “PlanetaMed”

Email: klushnik2004@mail.ru
Russian Federation, Moscow

G. V. Larionov

Medical Center “PlanetaMed”

Email: klushnik2004@mail.ru
Russian Federation, Moscow

A. N. Aleksandrenkova

Medical Center “PlanetaMed”

Email: klushnik2004@mail.ru
Russian Federation, Moscow

T. R. Sadykov

Medical Center “PlanetaMed”

Email: klushnik2004@mail.ru
Russian Federation, Moscow

A. M. Yugai

Medical Center “PlanetaMed”

Email: klushnik2004@mail.ru
Russian Federation, Moscow

Yu. V. Kazakova

Medical Center “PlanetaMed”

Email: klushnik2004@mail.ru
Russian Federation, Moscow

L. A. Mamedov

Medical Center “PlanetaMed”

Email: klushnik2004@mail.ru
Russian Federation, Moscow

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