Neuroimmune Disturbances in Animal Models of Aggressive Behavior

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Abstract

Immune dysregulation and inflammation play a key role in the pathogenesis of various affective disorders associated with excessive aggressiveness. Aggressive behavior formed in experimental models under influence of psychological stress or genetic factors is accompanied by changes in immune function, production of circulating cytokines, as well as temporal and region-dependent variations in their content within brain structures involved in behavior control and immunomodulation. Studying a role of neuroimmune interactions in the regulation of aggressive behavior is a fundamental challenge not only to advance our understanding of the neurobiological mechanisms underlying human aggression and violence, but also for developing effective approaches to its correction.

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About the authors

E. L. Alperina

Scientific-Research Institute of Neurosciences and Medicine

Email: galina-idova@mail.ru
Russian Federation, Novosibirsk

S. Ya. Zhanaeva

Scientific-Research Institute of Neurosciences and Medicine

Email: galina-idova@mail.ru
Russian Federation, Novosibirsk

G. V. Idova

Scientific-Research Institute of Neurosciences and Medicine

Author for correspondence.
Email: galina-idova@mail.ru
Russian Federation, Novosibirsk

References

  1. Popova N.K. // Bioessays. 2006. V. 28. P. 495–503.
  2. Popova N.K., Naumenko V.S., Kozhemyakina R.V., Plyusnina I.Z. // Neurosci. Behav. Physiol. 2010. V. 40. P. 357–361.
  3. Miczek K.A., de Boer S.F., Haller J. // Psychopharmacology (Berl). 2013. V. 226. P. 445–458.
  4. Кудрявцева Н.Н., Маркель А.Л., Орлов Ю.Л. // Вавиловский журнал генетики и селекции. 2014a. Т. 18. С. 1133–1155.
  5. de Boer S. F. // Curr. Opin. Psychol. 2018. V. 19. P. 81–87.
  6. Covington H.E. 3rd, Newman E.L., Leonard M.Z., Miczek K.A. // F1000Res. 2019. 8. F1000 Faculty Rev-963.
  7. Li W., Yang Y., Hong L., An F.R., Ungvari G.S., Ng C.H., Xiang Y.T. // Asian J Psychiatr. 2020. V. 47. P. 101846–101853.
  8. Hughes H.K., Moreno R.J., Ashwood P. // Brain Behav. Immun. 2023. V. 108. P. 245–254.
  9. Dantzer R. // Immunol. Allergy. Clin. North Am. 2009. V. 29. P. 247–264.
  10. Capuron L., Miller A. H. // Pharmacol. Ther. 2011. V. 130. P. 226–238.
  11. Bennett F.C., Molofsky A.V. // Clin. Exp. Immunol. 2019. V. 197. P. 294–307.
  12. Ветлугина Т.П., Прокопьева В.Д., Епимахова Е.В., Мандель А.И., Бойко А.С. // Патогенез. 2022. Т. 20. С. 73–74
  13. Coccaro E.F., Lee R., Breen E.C., Irwin M.R. // Neuropsychopharmacology. 2023. V. 48. P. 1060–1066.
  14. Devoino L., Alperina E., Kudryavtseva N., Popova N. // Brain Behav Immun. 1993. V. 7. P. 91–96.
  15. Petitto J.M. // Behavioral genetics and immunity / Ed. Ader R. et al., San Diego: Elsevier Academic Press, 2001. P. 173–186.
  16. Siegel A., Bhatt S., Bhatt R., Zalcman, S.S. // Curr. Neuropharmacol. 2007. V. 5. P. 135–147.
  17. Marsland A.L., Prather A.A., Petersen K L, Cohen S., Manuck S.B. // Brain Behav. Immun. 2008. V. 22. P. 753–761.
  18. Mommersteeg P.M., Vermetten E., Kavelaars A., Geuze E., Heijnen C.J. // Psychoendocrinology. 2008. V. 33. P. 1041–1050.
  19. Девойно Л.В., Идова Г.В., Альперина Е.Л. // Психонейроиммуномодуляция: поведение и иммунитет. Роль “нейромедиаторной установки мозга”. Новосибирск: Наука, 2009. 167 с.
  20. Idova G., Alperina E., Plyusnina I., Gevorgyan M., Zhukova E., Konoshenko M., Kozhemyakina R., Wang S-W // Neurosci. Lett. 2015. V. 609. P. 103–108.
  21. Idova G.V., Markova E.V., Gevorgyan M.M., Alperina E.L., Zhukova E.N. // Bull. Exp. Biol. Med. 2016a. V. 160. P. 679–682.
  22. Takahashi A., Flanigan M.E., McEven B.S., Russo S.J. // Front. Behav. Neurosci. 2018. V. 12. P. 56–62.
  23. Takahashi A., Aleyasin H., Stavarache M.A., Li L., Cathomas F., Parise L.F., Lin H.Y., Burnett C.J., Aubry A., Flanigan M.E., Brancato A., Menard C., Pfau M.L., Kana V., Wang J., Hodes G.E., Sasaki T., Kaplitt M.G., Ogawa S., McEwen B.S., Russo S.J. // Mol. Psychiatry. 2022. V. 27. P. 2563–2569.
  24. Takahashi A. // Neuropharmacology. 2024. V. 256. P. 110021–110040.
  25. Alperina E., Idova G., Zhukova E., Zhanaeva S., Kozhemyakina R. // Neurosci. Lett. 2019. V. 692. P. 193–198.
  26. Alperina E., Idova G., Zhanaeva S. // Rodent Modeling of Aggression, Elucidating the Role of Cytokines in the Brain / Ed. Martin C., Preedy V.R., Patel V.B. Cham (ZG): Springer. 2023. P. 1–20.
  27. Lotrich F.E., Albusaysi S., Ferrell R.E. // Neuropsychopharmacology. 2013. V. 38. P. 985–995.
  28. Suarez E.C., Lewis J.G., Kuch C. // Brain Behav. Immun. 2002. V.16. P. 675–684.
  29. Provensal N., Suderman M.J., Vitaro F., Szyf M., Tremblay R.E. // PLoS One. 2013. V. 8. P. e9481.
  30. Granger D.A., Booth A., Johnson D. R. // Psychosom. Med. 2000. V. 62. P. 583–590.
  31. Kiecolt-Glaser J.K., Loving T.J., Stowell J.R., Malarkey W.B, Lemeshow S., Dickinson S., Glaser R. // Arch. Gen. Psychiatry. 2005. V. 62. P. 1377–1384.
  32. Bartolomucci A. // Front. Neuroendocrinol. 2007. V. 28. P. 28–49.
  33. Audet M.C., Mangano E.N., Anisman H. // Front. Behav. Neurosci. 2010. V. 4. P. 156–168.
  34. Takahashi A., Miczek K. A. // Curr. Top. Behav. Neurosci. 2014. V. 17. P. 3–44.
  35. Snyder-Mackler N., Burger J.R., Gaydosh L., Belsky D.W., Noppert G.A., Campos F.A., Bartolomucci A., Yang Y.C., Aiello A.E., O’Rand A., Harris K.M., Shively C.A., Alberts S.C., Tung J. // Science. 2020. V. 368. P. eaax9553.
  36. Kudryavtseva N.N., Smagin D.A., Kovalenko I.L., Vishnivetskaya G.B. // Nat Protoc. 2014b. V. 9. P. 2705–2717.
  37. Павлова И.В., Брошевицкая Н.Д., Потехина А.А., Швадченко А.М. // Биохимия. 2024. Т. 89. № 9. C. 1582–1594.
  38. Драгович А.Ю., Боринская С.А. // Генетика. 2019. T. 55. C. 1381–1396.
  39. Давыдова Ю.Д., Литвинов С.С., Еникеева Р.Ф., Малых С.Б., Хуснутдинова Э.К. // Вавиловский журнал генетики и селекции. 2018. V. 22. P. 716–725.
  40. Pavlov K.A., Chistiakov D.A., Chekhonin V.P. // J. Appl. Genet. 2012. V. 53. P. 61–82.
  41. Naumenko V.S., Kondaurova E.M., Bazovkina D.V., Tsybko A.S., Il’chibaeva T.V., Popova N.K. // J. Neurosci. Res. 2014. V. 92. P. 1035–1043.
  42. Черепкова Е.В., Афтанас Л.И., Максимов В.Н., Меньшанов П.Н. // Бюл. эксперим. биологии и медицины. 2016. Т. 162. С. 95–98.
  43. Smagin D.A., Galyamina A.G., Kovalenko I.L., Kudryavtseva N.N. // Int. J. Mol. Sci. 2022. V. 23. P. 13644–13666.
  44. Popova N.K., Tsybko A.S., Naumenko V.S. // Int. J. Mol. Sci. 2022. V. 23. P. 8814–8841.
  45. Idova G.V., Alperina E.L., Cheido M.A. // Intern. Immunopharmacol. 2012. V. 12. P. 618–625.
  46. Альперина Е.Л. // Успехи физиологических наук. 2014. Т. 45. С. 45–56.
  47. Ilchibaeva T.V., Tsybko A.S., Kozhemyakina R.V., Kondaurova E.M., Popova N.K., Naumenko V.S. // Behav Brain Res. 2018. V. 343. P. 102–110.
  48. Pouget J.G. // Schizophr. Bull. 2018. V. 4. P. 993–1004.
  49. Bishop J.R., Zhang L., Lizano P. // Harv. Rev. Psychiatry. 2022. V. 30. P. 59–70.
  50. Suchankova P., Henningsson S., Baghaei F., Rosmond R., Holm G., Ekman A. // Genes. Brain. Behav. 2009. V. 2. P. 212–217.
  51. Patel A., Siegel A., Zalcman S. S. // Brain Behav. Immun. 2010. V. 24. P. 1276–1280.
  52. Tamagawa A., Kolosova I.E., Gerlinskaya L.A. Iakura Y., Endo Y., Moshkin M.P. // Psycheuroendocinol. Res. Trends, Nova Sci. Publishers Inc. 2007. P. 1–18.
  53. Lipina T V, Roder J C. // Neurosci Biobehav Rev. 2014. V. 45. P. 271–294.
  54. Serykh A., Khrapova M.V., Dubrovina N.I., Petrova E.S., Mikhnevich N., Starostina M.V., Amstislavskaya T.G., Lipina T.V. // Behav. Brain. Res. 2020. V. 392. P. 112693.
  55. Alperina E.L., Gevorgyan M.M., Zhanaeva S.Y., Lipina T.V., Idova G.V. // Bull Exp Biol Med. 2021. V.171. P. 347–351.
  56. Gevorgyan M. M., Zhanaeva S.Y., Alperina E.L. Lipina T.V., Idova G. V. // Vavilovskii Zhurnal Genet. Selektsii. 2020. V. 24. P. 770–776.
  57. Plyusnina I.Z., Solov’eva M.Y., Oskina I.N. // Behav. Genet. 2011. V. 41. P. 583–592.
  58. Albert F.W., Shchepina O., Winter C., Rӧmpler H., Teupser D., Palme R., Ceglarek U., Kratzsch J., Sohr R., Trut L.N., Thiery J., Morgrnstern R., Plyusnina I.Z., SchцnbergT., Pддbo S. // Horm Behav. 2008. V. 53. P. 413–421.
  59. Naumenko V.S., Kozhemyakina R.V., Plyusnina I.F., Kulikov A.V., Popova N.K. // Behav. Brain Res. 2013. V. 243. P. 97–101.
  60. Оськина И. Н., Гербек Ю.Э., Шихевич С.Г., Плюснина И.З., Гулевич Р.Г. // Вестник ВОГиС. 2008. Т. 12. С. 39–48.
  61. D’Mello C., Le N., Swain M.G. // J Neurosci. 2009. V. 29. P. 2089–2101.
  62. Bay-Richter C., Janelidze S., Hallberg L., Brundin L. // Behav. Brain Res. 2011. V. 222. P. 193–199.
  63. Alperina E., Zhukova E., Idova G., Kozhemyakina R., Cheido M. // Pharmacology & Pharmacy. 2015. V. 6. P. 451–459.
  64. Idova G.V., Alperina E.L., Zhukova E.N., Cheido M.A., Kozhemyakina R.V. // Pharmacology & Pharmacy. 2016b. V. 7. P. 313–320.

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