Neuroepigenomic Approaches in Translational Neurobiology: A Tribute to Prof. Nina K. Popova

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Abstract

The postmitotic nature of most neurons in human and animal brain emphasizes the importance of epigenetic and epigenomic regulation in CNS function. Epigenetic regulation includes heritable changes that are not associated with alterations in the DNA sequence. The less-studied epigenomic (epitranscriptomic) regulation involves mechanisms that alter the structure and function of expressed RNA without modifying its nucleotide sequence. Recent studies highlight the importance of these processes in the brain and their influence on the pathogenesis of various CNS diseases. Here, we review common known mechanisms of epitranscriptomic regulation, their roles in the CNS, and both clinical and preclinical data on epigenomic modulation of brain functions, with an emphasis on the use of traditional (rodents) and alternative model organisms (zebrafish). We also outline promising research directions in this field. The study is a tribute to memory of Professor Nina K. Popova (1929–2024), a long-time member of the editorial board of journal “Neirokhimiya”, a prominent woman-scientist, a teacher, and a remarkable person.

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About the authors

A. S. Lebedev

V.A. Almazov National Medical Research Center, Ministry of Healthcare of Russian Federation; Institute of Translational Biomedicine, St. Petersburg State University

Email: avkalueff@gmail.com
Russian Federation, St. Petersburg; St. Petersburg

N. O. Erofeeva

V.A. Almazov National Medical Research Center, Ministry of Healthcare of Russian Federation; Institute of Translational Biomedicine, St. Petersburg State University

Email: avkalueff@gmail.com
Russian Federation, St. Petersburg; St. Petersburg

M. M. Kotova

Sirius University of Science and Technology, Sirius Federal Territory

Email: avkalueff@gmail.com
Russian Federation, Krasnodar Region

D. S. Galstyan

V.A. Almazov National Medical Research Center, Ministry of Healthcare of Russian Federation; Institute of Translational Biomedicine, St. Petersburg State University

Email: avkalueff@gmail.com
Russian Federation, St. Petersburg; St. Petersburg

D. D. Martynov

V.A. Almazov National Medical Research Center, Ministry of Healthcare of Russian Federation; Institute of Translational Biomedicine, St. Petersburg State University

Email: avkalueff@gmail.com
Russian Federation, St. Petersburg; St. Petersburg

N. I. Golushko

V.A. Almazov National Medical Research Center, Ministry of Healthcare of Russian Federation; Institute of Translational Biomedicine, St. Petersburg State University

Email: avkalueff@gmail.com
Russian Federation, St. Petersburg; St. Petersburg

A. V. Kalueff

V.A. Almazov National Medical Research Center, Ministry of Healthcare of Russian Federation; Institute of Translational Biomedicine, St. Petersburg State University;
Sirius University of Science and Technology, Sirius Federal Territory

Author for correspondence.
Email: avkalueff@gmail.com
Russian Federation, St. Petersburg; St. Petersburg; Krasnodar Region

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2. Fig. 1. At a meeting with N.K. Popova (center) in the laboratory of behavioral neurogenetics that she created at the Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences (Novosibirsk, April 2022, from the personal archive of Prof. A.V. Kaluev, left).

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