Bacterial Polyhydroxyalkanoates-based Therapeutics-delivery Nano-systems


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Abstract

:Microbial polyhydroxyalkanoates (PHAs) are bio-based aliphatic biopolyester produced by bacteria as an intracellular storage material of carbon and energy under stressed conditions. PHAs have been paid attention to due to their unique and impressive biological properties including high biodegradability, biocompatibility, low cytotoxicity, and different mechanical properties. Under this context, the development of drug-delivery nanosystems based on PHAs has been revealed to have numerous advantages compared with synthetic polymers that included biocompatibility, biodegradability, non-toxic, and low-cost production, among others. In this review article, we present the available state of the art of PHAs. Moreover, we discussed the potential benefits, weaknesses, and perspectives of PHAs to the develop drug delivery systems.

About the authors

Esteban Durán-Lara

DuranLab; Bio & Nanomaterials, Faculty Health of Science, Universidad de Talca

Author for correspondence.
Email: info@benthamscience.net

Diana Rafael

Drug Delivery and Targeting Group, Molecular Biology and Biochemistry Research Centre for Nanomedicine (CIBBIM-Nanomedicine), Vall d'Hebron Institut de Recerca, Universitat Autònoma de Barcelona

Email: info@benthamscience.net

Fernanda Andrade

Drug Delivery and Targeting Group, Molecular Biology and Biochemistry Research Centre for Nanomedicine (CIBBIM-Nanomedicine), Vall d'Hebron Institut de Recerca, Universitat Autònoma de Barcelona

Email: info@benthamscience.net

Olga G.

Departamento de Microbiología, Facultad de Ciencias de la Salud,, Universidad de Talca

Email: info@benthamscience.net

Sekar Vijayakumar

, Marine College, Shandong University

Email: info@benthamscience.net

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