Thiazole, Isatin and Phthalimide Derivatives Tested in vivo against Cancer Models: A Literature Review of the Last Six Years
- Authors: Pinto A.1, Nunes J.2, Severino Martins J.E.3, Leal A.2, Silva C.4, da Silva A.4, da Cruz Olímpio D.2, da Silva E.2, Campos T.2, Lima Leite A.C.2
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Affiliations:
- Laboratory of Planning in Medicinal Chemistry, Department of Pharmaceutical Sciences, Center for Health Sciences,, Federal University of Pernambuco
- Laboratory of Planning in Medicinal Chemistry, Department of Pharmaceutical Sciences, Center for Health Sciences, Federal University of Pernambuco
- Regulatory Affairs Advisory, Empresa Brasileira de Hemoderivados e Biotecnologia (HEMOBRAS)
- 50740-520, Recife, PE, Federal University of Pernambuco
- Issue: Vol 31, No 20 (2024)
- Pages: 2991-3032
- Section: Anti-Infectives and Infectious Diseases
- URL: https://rjeid.com/0929-8673/article/view/645215
- DOI: https://doi.org/10.2174/0929867330666230426154055
- ID: 645215
Cite item
Full Text
Abstract
Background:Cancer is a disease characterized by the abnormal multiplication of cells and is the second leading cause of death in the world. The search for new effective and safe anticancer compounds is ongoing due to factors such as low selectivity, high toxicity, and multidrug resistance. Thus, heterocyclic compounds derived from isatin, thiazole and phthalimide that have achieved promising in vitro anticancer activity have been tested in vivo and in clinical trials.
Objective:This review focused on the compilation of promising data from thiazole, isatin, and phthalimide derivatives, reported in the literature between 2015 and 2022, with in vivo anticancer activity and clinical trials.
Methods:A bibliographic search was carried out in the PUBMED, MEDLINE, ELSEVIER, and CAPES PERIODIC databases, selecting relevant works for each pharmacophoric group with in vivo antitumor activity in the last 6 years.
Results:In our study, 68 articles that fit the scope were selected and critically analyzed. These articles were organized considering the type of antitumor activity and their year of publication. Some compounds reported here demonstrated potent antitumor activity against several tumor types.
Conclusion:This review allowed us to highlight works that reported promising structures for the treatment of various cancer types and also demonstrated that the privileged structures thiazole, isatin and phthalimide are important in the design of new syntheses and molecular optimization of compounds with antitumor activity.
Keywords
About the authors
Aline Pinto
Laboratory of Planning in Medicinal Chemistry, Department of Pharmaceutical Sciences, Center for Health Sciences,, Federal University of Pernambuco
Email: info@benthamscience.net
Janine Nunes
Laboratory of Planning in Medicinal Chemistry, Department of Pharmaceutical Sciences, Center for Health Sciences, Federal University of Pernambuco
Email: info@benthamscience.net
José Eduardo Severino Martins
Regulatory Affairs Advisory, Empresa Brasileira de Hemoderivados e Biotecnologia (HEMOBRAS)
Email: info@benthamscience.net
Amanda Leal
Laboratory of Planning in Medicinal Chemistry, Department of Pharmaceutical Sciences, Center for Health Sciences, Federal University of Pernambuco
Email: info@benthamscience.net
Carla Silva
50740-520, Recife, PE, Federal University of Pernambuco
Email: info@benthamscience.net
Anderson da Silva
50740-520, Recife, PE, Federal University of Pernambuco
Email: info@benthamscience.net
Daiane da Cruz Olímpio
Laboratory of Planning in Medicinal Chemistry, Department of Pharmaceutical Sciences, Center for Health Sciences, Federal University of Pernambuco
Email: info@benthamscience.net
Elineide da Silva
Laboratory of Planning in Medicinal Chemistry, Department of Pharmaceutical Sciences, Center for Health Sciences, Federal University of Pernambuco
Email: info@benthamscience.net
Thiers Campos
Laboratory of Planning in Medicinal Chemistry, Department of Pharmaceutical Sciences, Center for Health Sciences, Federal University of Pernambuco
Email: info@benthamscience.net
Ana Cristina Lima Leite
Laboratory of Planning in Medicinal Chemistry, Department of Pharmaceutical Sciences, Center for Health Sciences, Federal University of Pernambuco
Author for correspondence.
Email: info@benthamscience.net
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