Porphyrinuria in Autism Spectrum Disorder: A Review


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:Numerous studies demonstrated that the number of children with autism spectrum disorder (ASD) has increased remarkably in the past decade. A portion of ASD etiology, however, is attributed to environmental issues and genetic disorders. We highlighted a scoping review to principally evaluate the current information on mercury exposure in ASD children and to reveal knowledge gaps. Elevated porphyrins concentration in the urinary system related to mercury exposure, such as precoproporphyrin (prcP), coproporphyrin (cP), and pentacarboxyporphyrin (5cxP), was shown in comparison with controls. Moreover, high levels of urinary porphyrins have been elevated in response to heavy metal exposure. The related pattern (increased prcP, cP, and 5cxP) with Hg exposure may be used as biomarkers in the characteristics of ASD symptoms. However, this review highlighted the data gaps because the control groups were not genderand age-matched for ASD children.

作者简介

Geir Bjørklund

Department of Research,, Council for Nutritional and Environmental Medicine

编辑信件的主要联系方式.
Email: info@benthamscience.net

Yuliya Semenova

School of Medicine, Nazarbayev University

Email: info@benthamscience.net

Afaf El-Ansary

Autism Center, Lotus Holistic Alternative Medical Center

Email: info@benthamscience.net

Laila Al-Ayadhi

Department of Physiology, Faculty of Medicine, King Saud University

Email: info@benthamscience.net

参考

  1. Willsey, H.R.; Willsey, A.J.; Wang, B.; State, M.W. Genomics, convergent neuroscience and progress in understanding autism spectrum disorder. Nat. Rev. Neurosci., 2022, 23(6), 323-341. doi: 10.1038/s41583-022-00576-7 PMID: 35440779
  2. Baio, J.; Wiggins, L.; Christensen, D.L.; Maenner, M.J.; Daniels, J.; Warren, Z.; Kurzius-Spencer, M.; Zahorodny, W.; Robinson, C.; Rosenberg; White, T.; Durkin, M.S.; Imm, P.; Nikolaou, L.; Yeargin-Allsopp, M.; Lee, L-C.; Harrington, R.; Lopez, M.; Fitzgerald, R.T.; Hewitt, A.; Pettygrove, S.; Constantino, J.N.; Vehorn, A.; Shenouda, J.; Hall-Lande, J.; Van, K.; Naarden; Braun; Dowling, N.F. Prevalence of autism spectrum disorder among children aged 8 years — autism and developmental disabilities monitoring network, 11 sites, united states, 2014. MMWR Surveill. Summ., 2018, 67(6), 1-23. doi: 10.15585/mmwr.ss6706a1 PMID: 29701730
  3. Zeidan, J.; Fombonne, E.; Scorah, J.; Ibrahim, A.; Durkin, M.S.; Saxena, S.; Yusuf, A.; Shih, A.; Elsabbagh, M. Global prevalence of autism: A systematic review update. Autism Res., 2022, 15(5), 778-790. doi: 10.1002/aur.2696 PMID: 35238171
  4. Indika, N.L.R.; Deutz, N.E.P.; Engelen, M.P.K.J.; Peiris, H.; Wijetunge, S.; Perera, R. Sulfur amino acid metabolism and related metabotypes of autism spectrum disorder: A review of biochemical evidence for a hypothesis. Biochimie, 2021, 184, 143-157. doi: 10.1016/j.biochi.2021.02.018 PMID: 33675854
  5. Bowers, M.A.; Aicher, L.D.; Davis, H.A.; Woods, J.S. Quantitative determination of porphyrins in rat and human urine and evaluation of urinary porphyrin profiles during mercury and lead exposures. J. Lab. Clin. Med., 1992, 120(2), 272-281. PMID: 1500825
  6. Marks, G.S. Exposure to toxic agents: The heme biosynthetic pathway and hemoproteins as indicator. CRC Crit. Rev. Toxicol., 1985, 15(2), 151-180. doi: 10.3109/10408448509029323 PMID: 3899520
  7. Woods, J.S. Altered porphyrin metabolism as a biomarker of mercury exposure and toxicity. Can. J. Physiol. Pharmacol., 1996, 74(2), 210-215. doi: 10.1139/y96-010 PMID: 8723034
  8. Bjørklund, G.; Pivina, L.; Dadar, M.; Semenova, Y.; Chirumbolo, S.; Aaseth, J. Mercury exposure, epigenetic alterations and brain tumorigenesis: A possible relationship? Curr. Med. Chem., 2020, 27(39), 6596-6610. doi: 10.2174/0929867326666190930150159 PMID: 31566127
  9. Bjørklund, G.; Antonyak, H.; Polishchuk, A.; Semenova, Y.; Lesiv, M.; Lysiuk, R.; Peana, M. Effect of methylmercury on fetal neurobehavioral development: an overview of the possible mechanisms of toxicity and the neuroprotective effect of phytochemicals. Arch. Toxicol., 2022, 96(12), 3175-3199. doi: 10.1007/s00204-022-03366-3 PMID: 36063174
  10. Wang, L.; Angley, M.T.; Gerber, J.P.; Sorich, M.J. A review of candidate urinary biomarkers for autism spectrum disorder. Biomarkers, 2011, 16(7), 537-552. doi: 10.3109/1354750X.2011.598564 PMID: 22022826
  11. Kern, J.K.; Geier, D.A.; Adams, J.B.; Mehta, J.A.; Grannemann, B.D.; Geier, M.R. Toxicity biomarkers in autism spectrum disorder: A blinded study of urinary porphyrins. Pediatr. Int., 2011, 53(2), 147-153. doi: 10.1111/j.1442-200X.2010.03196.x PMID: 20626635
  12. Hessel, L. Mercury in vaccines. Bull. Acad Natl. Med., 2003, 187(8), 1501-1510. doi: 10.1016/S0001-4079(19)33886-5 PMID: 15146581
  13. Kern, J.K.; Hooker, B.S.; King, P.G.; Sykes, L.K.; Geier, M.R.; Geier, D. Thimerosal-containing hepatitis b vaccination and the risk for diagnosed specific delays in development in the united states: A case-control study in the vaccine safety datalink. N. Am. J. Med. Sci., 2014, 6(10), 519-531. doi: 10.4103/1947-2714.143284 PMID: 25489565
  14. Encyclopedia of the Nations France. Energy and Power., Available from: http://www.nationsencyclopedia. com/Europe/ France-ENERGY-AND-POWER.html (Accessed on 1 April 2023).
  15. Park, Y.; Lee, A.; Choi, K.; Kim, H.J.; Lee, J.J.; Choi, G.; Kim, S.; Kim, S.Y.; Cho, G.J.; Suh, E.; Kim, S.K.; Eun, S.H.; Eom, S.; Kim, S.; Kim, G.H.; Moon, H.B.; Kim, S.; Choi, S.; Kim, Y.D.; Kim, J.; Park, J. Exposure to lead and mercury through breastfeeding during the first month of life: A CHECK cohort study. Sci. Total Environ., 2018, 612, 876-883. doi: 10.1016/j.scitotenv.2017.08.079 PMID: 28886539
  16. Kusanagi, E.; Takamura, H.; Chen, S.J.; Adachi, M.; Hoshi, N. Children’s hair mercury concentrations and seafood consumption in five regions of japan. Arch. Environ. Contam. Toxicol., 2018, 74(2), 259-272. doi: 10.1007/s00244-017-0502-x PMID: 29313075
  17. Woods, J.S.; Kardish, R.M. Developmental aspects of hepatic heme biosynthetic capability and hematotoxicity—II. Studies on uroporphyrinogen decarboxylase. Biochem. Pharmacol., 1983, 32(1), 73-78. doi: 10.1016/0006-2952(83)90655-X PMID: 6219675
  18. Božek, P.; Hutta, M.; Hrivnáková, B. Rapid analysis of porphyrins at low ng/l and µg/l levels in human urine by a gradient liquid chromatography method using octadecylsilica monolithic columns. J. Chromatogr. A, 2005, 1084(1-2), 24-32. doi: 10.1016/j.chroma.2005.06.007 PMID: 16114232
  19. Brewster, M.A. Biomarkers of xenobiotic exposures. Ann. Clin. Lab. Sci., 1988, 18(4), 306-317. PMID: 3044268
  20. Khaled, E.M.; Meguid, N.A.; Bjørklund, G.; Gouda, A.; Bahary, M.H.; Hashish, A.; Sallam, N.M.; Chirumbolo, S.; El-Bana, M.A. Altered urinary porphyrins and mercury exposure as biomarkers for autism severity in Egyptian children with autism spectrum disorder. Metab. Brain Dis., 2016, 31(6), 1419-1426. doi: 10.1007/s11011-016-9870-6 PMID: 27406246
  21. Chernova, T.; Nicotera, P.; Smith, A.G. Heme deficiency is associated with senescence and causes suppression of N-methyl-D-aspartate receptor subunits expression in primary cortical neurons. Mol. Pharmacol., 2006, 69(3), 697-705. doi: 10.1124/mol.105.016675 PMID: 16306232
  22. Sengupta, A.; Hon, T.; Zhang, L. Heme deficiency suppresses the expression of key neuronal genes and causes neuronal cell death. Brain Res. Mol. Brain Res., 2005, 137(1-2), 23-30. doi: 10.1016/j.molbrainres.2005.02.007 PMID: 15950757
  23. Litman, D.A.; Correia, M.A. L-tryptophan: A common denominator of biochemical and neurological events of acute hepatic porphyria? Science, 1983, 222(4627), 1031-1033. doi: 10.1126/science.6648517 PMID: 6648517
  24. Litman, D.A.; Correia, M.A. Elevated brain tryptophan and enhanced 5-hydroxytryptamine turnover in acute hepatic heme deficiency: clinical implications. J. Pharmacol. Exp. Ther., 1985, 232(2), 337-345. PMID: 3968635
  25. Anderson, B.M.; Schnetz-Boutaud, N.C.; Bartlett, J.; Wotawa, A.M.; Wright, H.H.; Abramson, R.K.; Cuccaro, M.L.; Gilbert, J.R.; Pericak-Vance, M.A.; Haines, J.L. Examination of association of genes in the serotonin system to autism. Neurogenetics, 2009, 10(3), 209-216. doi: 10.1007/s10048-009-0171-7 PMID: 19184136
  26. Bill, B.R.; Geschwind, D.H. Genetic advances in autism: heterogeneity and convergence on shared pathways. Curr. Opin. Genet. Dev., 2009, 19(3), 271-278. doi: 10.1016/j.gde.2009.04.004 PMID: 19477629
  27. Chernova, T.; Steinert, J.R.; Guerin, C.J.; Nicotera, P.; Forsythe, I.D.; Smith, A.G. Neurite degeneration induced by heme deficiency mediated via inhibition of NMDA receptor-dependent extracellular signal-regulated kinase 1/2 activation. J. Neurosci., 2007, 27(32), 8475-8485. doi: 10.1523/JNEUROSCI.0792-07.2007 PMID: 17687025
  28. Chernova, T.; Steinert, J.R.; Richards, P.; Mistry, R.; Challiss, R.A.J.; Jukes-Jones, R.; Cain, K.; Smith, A.G.; Forsythe, I.D. Early failure of N-methyl-D-aspartate receptors and deficient spine formation induced by reduction of regulatory heme in neurons. Mol. Pharmacol., 2011, 79(5), 844-854. doi: 10.1124/mol.110.069831 PMID: 21325018
  29. Wall, D.P.; Esteban, F.J.; DeLuca, T.F.; Huyck, M.; Monaghan, T.; Velez de Mendizabal, N.; Goñí, J.; Kohane, I.S. Comparative analysis of neurological disorders focuses genome-wide search for autism genes. Genomics, 2009, 93(2), 120-129. doi: 10.1016/j.ygeno.2008.09.015 PMID: 18950700
  30. Chung, C.; Ha, S.; Kang, H.; Lee, J.; Um, S.M.; Yan, H.; Yoo, Y.E.; Yoo, T.; Jung, H.; Lee, D.; Lee, E.; Lee, S.; Kim, J.; Kim, R.; Kwon, Y.; Kim, W.; Kim, H.; Duffney, L.; Kim, D.; Mah, W.; Won, H.; Mo, S.; Kim, J.Y.; Lim, C.S.; Kaang, B.K.; Boeckers, T.M.; Chung, Y.; Kim, H.; Jiang, Y.; Kim, E. Early correction of N-Methyl-D-Aspartate receptor function improves autistic-like social behaviors in adult shank2−/− Mice. Biol. Psychiatry, 2019, 85(7), 534-543. doi: 10.1016/j.biopsych.2018.09.025 PMID: 30466882
  31. Ball, H.J.; Fedelis, F.F.; Bakmiwewa, S.M.; Hunt, N.H.; Yuasa, H.J. Tryptophan-catabolizing enzymes - party of three. Front. Immunol., 2014, 5, 485. doi: 10.3389/fimmu.2014.00485 PMID: 25346733
  32. Chugani, D.C.; Muzik, O.; Behen, M.; Rothermel, R.; Janisse, J.J.; Lee, J.; Chugani, H.T. Developmental changes in brain serotonin synthesis capacity in autistic and nonautistic children. Ann. Neurol., 1999, 45(3), 287-295. doi: 10.1002/1531-8249(199903)45:33.0.CO;2-9 PMID: 10072042
  33. Cook, E.H., Jr; Leventhal, B.L. The serotonin system in autism. Curr. Opin. Pediatr., 1996, 8(4), 348-354. doi: 10.1097/00008480-199608000-00008 PMID: 9053096
  34. Leboyer, M.; Philippe, A.; Bouvard, M.; Guilloud-Bataille, M.; Bondoux, D.; Tabuteau, F.; Feingold, J.; Mouren-Simeoni, M.C.; Launay, J.M. Whole blood serotonin and plasma beta-endorphin in autistic probands and their first-degree relatives. Biol. Psychiatry, 1999, 45(2), 158-163. doi: 10.1016/S0006-3223(97)00532-5 PMID: 9951562
  35. Owley, T.; Leventhal, B.L.; Cook, E.H. Childhood disorders: The autism spectrum disorders. In: Psychiatry, 2nd ed; Tasman, A.; Kay, J.; Lieberman, J.A., Eds.; Wiley, USA: Chichester, 2003; pp. 757-770.
  36. Geier, D.A.; Geier, M.R. A prospective assessment of porphyrins in autistic disorders: A potential marker for heavy metal exposure. Neurotox. Res., 2006, 10(1), 57-63. doi: 10.1007/BF03033334 PMID: 17000470
  37. Kern, J.K.; Geier, D.A.; Sykes, L.; Geier, M. Urinary porphyrins in autism spectrum disorders. In: In Comprehensive Guide to Autism; Springer New York, USA, 2014; pp. 1333-1348. doi: 10.1007/978-1-4614-4788-7_72
  38. Adams, J.B.; Baral, M.; Geis, E.; Mitchell, J.; Ingram, J.; Hensley, A.; Zappia, I.; Newmark, S.; Gehn, E.; Rubin, R.A.; Mitchell, K.; Bradstreet, J.; El-Dahr, J.M. The severity of autism is associated with toxic metal body burden and red blood cell glutathione levels. J. Toxicol., 2009, 2009, 1-7. doi: 10.1155/2009/532640 PMID: 20107587
  39. Woods, J.S. Porphyrin metabolism as indicator of metal exposure and toxicity. In: Toxicology of Metals: Biochemical Aspects; Goyer, R.A.; Cherian, M.G., Eds.; Handbook of Experimental PharmacologySpringer-Verlag: Berlin, Germany, 1995; pp. 15-92. doi: 10.1007/978-3-642-79162-8_2
  40. Macedoni-Lukšič, M.; Gosar, D.; Bjørklund, G.; Oražem, J.; Kodrič, J.; Lešnik-Musek, P.; Zupančič, M.; France-Štiglic, A.; Sešek-Briški, A.; Neubauer, D.; Osredkar, J. Levels of metals in the blood and specific porphyrins in the urine in children with autism spectrum disorders. Biol. Trace Elem. Res., 2015, 163(1-2), 2-10. doi: 10.1007/s12011-014-0121-6 PMID: 25234471
  41. Pingree, S.D.; Simmonds, P.L.; Woods, J.S. Effects of 2,3-dimercapto-1-propanesulfonic acid (DMPS) on tissue and urine mercury levels following prolonged methylmercury exposure in rats. Toxicol. Sci., 2001, 61(2), 224-233. a doi: 10.1093/toxsci/61.2.224 PMID: 11353131
  42. Pingree, S.D.; Simmonds, P.L.; Rummel, K.T.; Woods, J.S. Quantitative evaluation of urinary porphyrins as a measure of kidney mercury content and mercury body burden during prolonged methylmercury exposure in rats. Toxicol. Sci., 2001, 61(2), 234-240. b doi: 10.1093/toxsci/61.2.234 PMID: 11353132
  43. Liu, X.; Liu, X.; Tao, M.; Zhang, W. A highly selective and sensitive recyclable colorimetric Hg 2+ sensor based on the porphyrin-functionalized polyacrylonitrile fiber. J. Mater. Chem. A Mater. Energy Sustain., 2015, 3(25), 13254-13262. doi: 10.1039/C5TA02491A
  44. Zhang, L.; Wang, Z.W.; Xiao, S.J.; Peng, D.; Chen, J.Q.; Liang, R.P.; Jiang, J.; Qiu, J.D. Fluorescent molybdenum oxide quantum dots and Hg II synergistically accelerate cobalt porphyrin formation: A new strategy for trace Hg II analysis. ACS Appl. Nano Mater., 2018, 1(4), 1484-1491. doi: 10.1021/acsanm.7b00351
  45. Nataf, R.; Skorupka, C.; Amet, L.; Lam, A.; Springbett, A.; Lathe, R. Porphyrinuria in childhood autistic disorder: Implications for environmental toxicity. Toxicol. Appl. Pharmacol., 2006, 214(2), 99-108. doi: 10.1016/j.taap.2006.04.008 PMID: 16782144
  46. Geier, D.A.; Geier, M.R. A prospective study of mercury toxicity biomarkers in autistic spectrum disorders. J. Toxicol. Environ. Health A, 2007, 70(20), 1723-1730. doi: 10.1080/15287390701457712 PMID: 17885929
  47. Geier, D.A.; Kern, J.K.; Garver, C.R.; Adams, J.B.; Audhya, T.; Nataf, R.; Geier, M.R. Biomarkers of environmental toxicity and susceptibility in autism. J. Neurol. Sci., 2009, 280(1-2), 101-108. a doi: 10.1016/j.jns.2008.08.021 PMID: 18817931
  48. Austin, D.W.; Shandley, K. An investigation of porphyrinuria in Australian children with autism. J. Toxicol. Environ. Health A, 2008, 71(20), 1349-1351. doi: 10.1080/15287390802271723 PMID: 18704827
  49. Skogheim, T.S.; Weyde, K.V.F.; Engel, S.M.; Aase, H.; Surén, P.; Øie, M.G.; Biele, G.; Reichborn-Kjennerud, T.; Caspersen, I.H.; Hornig, M.; Haug, L.S.; Villanger, G.D. Metal and essential element concentrations during pregnancy and associations with autism spectrum disorder and attention-deficit/hyperactivity disorder in children. Environ. Int., 2021, 152, 106468. doi: 10.1016/j.envint.2021.106468 PMID: 33765546
  50. Baj, J.; Flieger, W.; Flieger, M.; Forma, A.; Sitarz, E.; Skórzyńska-Dziduszko, K.; Grochowski, C.; Maciejewski, R.; Karakuła-Juchnowicz, H. Autism spectrum disorder: Trace elements imbalances and the pathogenesis and severity of autistic symptoms. Neurosci. Biobehav. Rev., 2021, 129, 117-132. doi: 10.1016/j.neubiorev.2021.07.029 PMID: 34339708
  51. Zhang, J.; Li, X.; Shen, L.; Khan, N.U.; Zhang, X.; Chen, L.; Zhao, H.; Luo, P. Trace elements in children with autism spectrum disorder: A meta-analysis based on case-control studies. J. Trace Elem. Med. Biol., 2021, 67, 126782. doi: 10.1016/j.jtemb.2021.126782 PMID: 34049201
  52. Geier, D.A.; Kern, J.K.; Geier, M.R. A prospective blinded evaluation of urinary porphyrins verses the clinical severity of autism spectrum disorders. J. Toxicol. Environ. Health A, 2009, 72(24), 1585-1591. b doi: 10.1080/15287390903232475 PMID: 20077233
  53. Shandley, K.; Austin, D.W.; Bhowmik, J.L. Are urinary porphyrins a valid diagnostic biomarker of autism spectrum disorder? Autism Res., 2014, 7(5), 535-542. doi: 10.1002/aur.1385 PMID: 24756868
  54. Harutyunyan, A.A.; Harutyunyan, H.A.; Yenkoyan, K.B. Novel probable glance at inflammatory scenario development in autistic pathology. Front. Psychiatry, 2021, 12, 788779. doi: 10.3389/fpsyt.2021.788779 PMID: 35002805
  55. Adams, J.; Howsmon, D.P.; Kruger, U.; Geis, E.; Gehn, E.; Fimbres, V.; Pollard, E.; Mitchell, J.; Ingram, J.; Hellmers, R.; Quig, D.; Hahn, J. Significant association of urinary toxic metals and autism-related symptoms—A nonlinear statistical analysis with cross validation. PLoS One, 2017, 12(1), e0169526. doi: 10.1371/journal.pone.0169526 PMID: 28068407
  56. Youn, S.I.; Jin, S.H.; Kim, S.H.; Lim, S. Porphyrinuria in Korean children with autism: Correlation with oxidative stress. J. Toxicol. Environ. Health A, 2010, 73(10), 701-710. doi: 10.1080/15287391003614000 PMID: 20391113
  57. Fujiwara, T.; Morisaki, N.; Honda, Y.; Sampei, M.; Tani, Y. Chemicals, nutrition, and autism spectrum disorder: A mini-review. Front. Neurosci., 2016, 20, 174. doi: 10.3389/fnins.2016.00174
  58. Heyer, N.J.; Echeverria, D.; Woods, J.S. Disordered porphyrin metabolism: A potential biological marker for autism risk assessment. Autism Res., 2012, 5(2), 84-92. doi: 10.1002/aur.236 PMID: 22298513
  59. Adrien, J.L.; Barthélémy, C.; Lelord, G.; Muh, J.P. Use of bioclinical markers for the assessment and treatment of children with pervasive developmental disorders. Neuropsychobiology, 1989, 22(3), 117-124. doi: 10.1159/000118604 PMID: 2485858
  60. Bailey, W.J.; Ulrich, R. Molecular profiling approaches for identifying novel biomarkers. Expert Opin. Drug Saf., 2004, 3(2), 137-151. doi: 10.1517/14740338.3.2.137 PMID: 15006720
  61. Pardo, C.A.; Eberhart, C.G. The neurobiology of autism. Brain Pathol., 2007, 17(4), 434-447. doi: 10.1111/j.1750-3639.2007.00102.x PMID: 17919129
  62. Žigman, T.; Petković Ramadža, D.; Šimić, G.; Barić, I. Inborn errors of metabolism associated with autism spectrum disorders: Approaches to intervention. Front. Neurosci., 2021, 15, 673600. doi: 10.3389/fnins.2021.673600 PMID: 34121999
  63. Moravej, H.; Inaloo, S.; Nahid, S.; Mazloumi, S.; Nemati, H.; Moosavian, T.; Nasiri, J.; Ghasemi, F.; Alaei, M.R.; Dalili, S.; Aminzadeh, M.; Katibeh, P.; Amirhakimi, A.; Yazdani, N.; Ilkhanipoor, H.; Afshar, Z.; Hadipour, F.; Hadipour, Z. Inborn errors of metabolism associated with autism among children: A multicenter study from iran. Indian Pediatr., 2023, 60(3), 193-196. doi: 10.1007/s13312-023-2833-1 PMID: 36604934
  64. Ahmadabadi, F.; Nemati, H.; Abdolmohammadzadeh, A.; Ahadi, A. Autistic feature as a presentation of inborn errors of metabolism. Iran. J. Child. Neurol., 2020, 14(4), 17-28. PMID: 33193781
  65. Woods, J.S.; Armel, S.E.; Fulton, D.I.; Allen, J.; Wessels, K.; Simmonds, P.L.; Granpeesheh, D.; Mumper, E.; Bradstreet, J.J.; Echeverria, D.; Heyer, N.J.; Rooney, J.P.K. Urinary porphyrin excretion in neurotypical and autistic children. Environ. Health Perspect., 2010, 118(10), 1450-1457. doi: 10.1289/ehp.0901713 PMID: 20576582
  66. Ogun, A.S.; Joy, N.V.; Valentine, M. Biochemistry, heme synthesis. In: StatPearls; StatPearls Publishing: Treasure Island, FL, 2023. https://www.ncbi.nlm.nih.gov/books/NBK537329/ Internet
  67. Shiani, A.; Sharafi, K.; Omer, A.K.; Kiani, A.; Karamimatin, B.; Massahi, T.; Ebrahimzadeh, G. A systematic literature review on the association between exposures to toxic elements and an autism spectrum disorder. Sci. Total Environ., 2023, 857(Pt 2), 159246. doi: 10.1016/j.scitotenv.2022.159246 PMID: 36220469
  68. Rossignol, D. The use of urinary porphyrins analysis in autism. Medical Veritas, 2007, 4, 1-6. doi: 10.1588/medver.2007.04.00140
  69. Dutt, S.; Hamza, I.; Bartnikas, T.B. Molecular mechanisms of iron and heme metabolism. Annu. Rev. Nutr., 2022, 42(1), 311-335. doi: 10.1146/annurev-nutr-062320-112625 PMID: 35508203
  70. Geier, D.; Kern, J.; King, P.; Sykes, L.; Geier, M. Hair toxic metal concentrations and autism spectrum disorder severity in young children. Int. J. Environ. Res. Public Health, 2012, 9(12), 4486-4497. doi: 10.3390/ijerph9124486 PMID: 23222182
  71. Roy, S.; Gupta, S.K.; Prakash, J.; Habib, G.; Kumar, P. A global perspective of the current state of heavy metal contamination in road dust. Environ. Sci. Pollut. Res. Int., 2022, 29(22), 33230-33251. doi: 10.1007/s11356-022-18583-7 PMID: 35022986
  72. Grandjean, P.; Landrigan, P.J. Neurobehavioural effects of developmental toxicity. Lancet Neurol., 2014, 13(3), 330-338. doi: 10.1016/S1474-4422(13)70278-3 PMID: 24556010
  73. Farías, P.; Hernández-Bonilla, D.; Moreno-Macías, H.; Montes-López, S.; Schnaas, L.; Texcalac-Sangrador, J.L.; Ríos, C.; Riojas-Rodríguez, H. Prenatal co-exposure to manganese, mercury, and lead, and neurodevelopment in children during the first year of life. Int. J. Environ. Res. Public Health, 2022, 19(20), 13020. doi: 10.3390/ijerph192013020 PMID: 36293596
  74. Jangid, A.P.; John, P.J.; Yadav, D.; Mishra, S.; Sharma, P. Impact of chronic lead exposure on selected biological markers. Indian J. Clin. Biochem., 2012, 27(1), 83-89. doi: 10.1007/s12291-011-0163-x PMID: 23277717
  75. Sun, J.; Wang, J.; Liu, J. Effects of lead exposure on porphyrin metabolism indicators in smelter workers. Biomed. Environ. Sci., 1992, 5(1), 76-85. PMID: 1586470
  76. Lefever, S.; Peersman, N.; Meersseman, W.; Cassiman, D.; Vermeersch, P. Development and validation of diagnostic algorithms for the laboratory diagnosis of porphyrias. J. Inherit. Metab. Dis., 2022, 45(6), 1151-1162. doi: 10.1002/jimd.12545 PMID: 36053909
  77. James, M.F.M.; Hift, R.J. Porphyrias. Br. J. Anaesth., 2000, 85(1), 143-153. doi: 10.1093/bja/85.1.143 PMID: 10928003
  78. Ruha, A.M. Recommendations for provoked challenge urine testing. J. Med. Toxicol., 2013, 9(4), 318-325. doi: 10.1007/s13181-013-0350-7 PMID: 24113861
  79. Poli, A.; Schmitt, C.; Moulouel, B.; Mirmiran, A.; Puy, H.; Lefèbvre, T.; Gouya, L. Iron, heme synthesis and erythropoietic porphyrias: A complex interplay. Metabolites, 2021, 11(12), 798. doi: 10.3390/metabo11120798 PMID: 34940556
  80. Di Pierro, E.; De Canio, M.; Mercadante, R.; Savino, M.; Granata, F.; Tavazzi, D.; Nicolli, A.M.; Trevisan, A.; Marchini, S.; Fustinoni, S. Laboratory diagnosis of porphyria. Diagnostics, 2021, 11(8), 1343. doi: 10.3390/diagnostics11081343 PMID: 34441276
  81. Baraskewich, J.; von Ranson, K.M.; McCrimmon, A.; McMorris, C.A. Feeding and eating problems in children and adolescents with autism: A scoping review. Autism, 2021, 25(6), 1505-1519. doi: 10.1177/1362361321995631 PMID: 33653157
  82. Di Pierro, E.; Granata, F. Nutrients and porphyria: An intriguing crosstalk. Int. J. Mol. Sci., 2020, 21(10), 3462. doi: 10.3390/ijms21103462 PMID: 32422947
  83. Hirota, T.; King, B.H. Autism spectrum disorder. JAMA, 2023, 329(2), 157-168. doi: 10.1001/jama.2022.23661 PMID: 36625807
  84. Plaza-Diaz, J.; Flores-Rojas, K.; Torre-Aguilar, M.J.; Gomez-Fernández, A.R.; Martín-Borreguero, P.; Perez-Navero, J.L.; Gil, A.; Gil-Campos, M. Dietary patterns, eating behavior, and nutrient intakes of spanish preschool children with autism spectrum disorders. Nutrients, 2021, 13(10), 3551. doi: 10.3390/nu13103551 PMID: 34684552
  85. Mizejewski, G.J.; Lindau-Shepard, B.; Pass, K.A. Newborn screening for autism: in search of candidate biomarkers. Biomarkers Med., 2013, 7(2), 247-260. doi: 10.2217/bmm.12.108 PMID: 23547820
  86. Melman, S.T.; Nimeh, J.W.; Anbar, R.D. Prevalence of elevated blood lead levels in an inner-city pediatric clinic population. Environ. Health Perspect., 1998, 106(10), 655-657. doi: 10.1289/ehp.106-1533171 PMID: 9755141
  87. Bełdowska, M.; Falkowska, L. Mercury in marine fish, mammals, seabirds, and human hair in the coastal zone of the Southern Baltic. Water Air Soil Pollut., 2016, 227(2), 52. doi: 10.1007/s11270-015-2735-5 PMID: 26806985
  88. Grade, T.; Campbell, P.; Cooley, T.; Kneeland, M.; Leslie, E.; MacDonald, B.; Melotti, J.; Okoniewski, J.; Parmley, E.J.; Perry, C.; Vogel, H.; Pokras, M. Lead poisoning from ingestion of fishing gear: A review. Ambio, 2019, 48(9), 1023-1038. doi: 10.1007/s13280-019-01179-w PMID: 31020613
  89. van Rossum, H.H. Technical quality assurance and quality control for medical laboratories: a review and proposal of a new concept to obtain integrated and validated QA/QC plans. Crit. Rev. Clin. Lab. Sci., 2022, 59(8), 586-600. doi: 10.1080/10408363.2022.2088685 PMID: 35758201
  90. Bölte, S.; Girdler, S.; Marschik, P.B. The contribution of environmental exposure to the etiology of autism spectrum disorder. Cell. Mol. Life Sci., 2019, 76(7), 1275-1297. doi: 10.1007/s00018-018-2988-4 PMID: 30570672
  91. James, S.; Stevenson, S.W.; Silove, N.; Williams, K. Chelation for autism spectrum disorder (ASD). Cochrane Libr., 2015, 2016(10), CD010766. doi: 10.1002/14651858.CD010766.pub2 PMID: 26114777
  92. Flora, S.J.S.; Pachauri, V. Chelation in metal intoxication. Int. J. Environ. Res. Public Health, 2010, 7(7), 2745-2788. doi: 10.3390/ijerph7072745 PMID: 20717537
  93. Blaucok-Busch, E.; Amin, O.R.; Dessoki, H.H.; Rabah, T. Efficacy of DMSA therapy in a sample of arab children with autistic spectrum disorder. Maedica , 2012, 7(3), 214-221. PMID: 23400264
  94. Geier, D.A.; Geier, M.R. A clinical trial of combined anti-androgen and anti-heavy metal therapy in autistic disorders. Neuroendocrinol. Lett., 2006, 27(6), 833-838. PMID: 17187010
  95. FDA Warns Seller of Pills Used to Treat Autism. Available from: https://www.consumerlab.com/recalls/10204/fda-warns-seller-of-pills-used-to-treat-autism/ (Accessed on 30 August 2023).
  96. Beauchamp, R.A.; Willis, T.M.; Betz, T.G.; Villanacci, J.; Leiker, R.D.; Rozin, L. Deaths associated with hypocalcemia from chelation therapy – Texas, Pennsylvania, and Oregon, 2003–2005. JAMA, 2006, 295(18), 2131-2133. doi: 10.1001/jama.295.18.2131
  97. Mitka, M. Chelation therapy trials halted. JAMA, 2008, 300(19), 2236. doi: 10.1001/jama.2008.607 PMID: 19017902
  98. Davis, T.N.; O’Reilly, M.; Kang, S.; Lang, R.; Rispoli, M.; Sigafoos, J.; Lancioni, G.; Copeland, D.; Attai, S.; Mulloy, A. Chelation treatment for autism spectrum disorders: A systematic review. Res. Autism Spectr. Disord., 2013, 7(1), 49-55. doi: 10.1016/j.rasd.2012.06.005
  99. Adams, J.B.; Baral, M.; Geis, E.; Mitchell, J.; Ingram, J.; Hensley, A.; Zappia, I.; Newmark, S.; Gehn, E.; Rubin, R.A.; Mitchell, K.; Bradstreet, J.; El-Dahr, J. Safety and efficacy of oral DMSA therapy for children with autism spectrum disorders: Part A - Medical results. BMC Clin. Pharmacol., 2009, 9(1), 16. doi: 10.1186/1472-6904-9-16

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