Medicinal Aspects of PTP1B Inhibitors as Anti-Breast Cancer Agents: An Overview


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Abstract

:Protein tyrosine phosphatase 1B (PTP1B) has gained interest as a therapeutic target for type 2 diabetes and obesity. Besides metabolic signalling, PTP1B is a positive regulator of signalling pathways linked to ErbB2-induced breast tumorigenesis. Substan-tial evidence proves that its overexpression is involved in breast cancer, which suggests that selective PTP1B inhibition might be effective in breast cancer treatment. Therefore, huge research is being carried out on PTP1B inhibitors and their activity against breast cancer development. To date, only two PTP1B inhibitors, viz. ertiprotafib and tro-dusquemine, have entered clinical trials. The discovery of selective inhibitors of PTP1B could open a new avenue in breast cancer treatment. In this review, we provide an exten-sive overview on the involvement of PTP1B in breast cancer, its pathophysiology, with special attention on the discovery and development of various natural as well as synthetic PTP1B inhibitors. This study will provide significant information to the researchers de-veloping PTP1B inhibitors for breast cancer treatment.

About the authors

Rakesh Khator

Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab

Email: info@benthamscience.net

Avadh Biharee

Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab

Email: info@benthamscience.net

Neha Bhatia

Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab

Email: info@benthamscience.net

Swanand Kulkarni

Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab

Email: info@benthamscience.net

Yogesh Singh

Department of Pharmaceutical Science and Natural Products, Central University of Punjab

Email: info@benthamscience.net

Chandrabose Karthikeyan

Department of Pharmacy,, Indira Gandhi National Tribal University

Email: info@benthamscience.net

Akhlesh Jain

School of Pharmaceutical Sciences, Guru Ghasidas Central University

Author for correspondence.
Email: info@benthamscience.net

Suresh Thareja

Department of Pharmaceutical Sciences and Natural Products, Central University of Punjab

Author for correspondence.
Email: info@benthamscience.net

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