Synthesis, sympatholytic and adrenolytic activity of aminoamides and aminоesters on the base of 1-(benzo[ d ][1,3]dioxol-5-yl)-cyclopentane- and 4-(benzo[ d ][1,3]dioxol-5-yl)tetrahydro-2 H -pyrane-4-carboxylic acids

R. E. Margaryan; Маркарян Рузанна Эдуардовна; G. V. Stepanyan; Степанян Гаяне Вардановна; A. A. Aghekyan; Агекян Aся Aгековна; H. A. Panosyan; Паносян Генрих Агавардович; S. A. Arutyunyan; Арутюнян Седа Арутюновна; A. S. Tsatinyan; Цатинян Аник Суреновна; M. S. Grigoryan; Григорян Марине Сениковна; G. G. Mkryan; Мкрян Геворг Гургенович

doi:10.31857/S0514749225030095

Synthesis, sympatholytic and adrenolytic activity of aminoamides and aminоesters on the base of 1-(benzo[d][1,3]dioxol-5-yl)-cyclopentane- and 4-(benzo[d][1,3]dioxol-5-yl)tetrahydro-2H-pyrane-4-carboxylic acids

Authors: Margaryan R.E.¹, Stepanyan G.V.¹, Aghekyan A.A.¹, Panosyan H.A.¹, Arutyunyan S.A.¹, Tsatinyan A.S.¹, Grigoryan M.S.¹, Mkryan G.G.¹
Affiliations:
1. The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
Issue: Vol 61, No 3 (2025)
Pages: 293-301
Section: ЭКСПЕРИМЕНТАЛЬНЫЕ СТАТЬИ
URL: https://rjeid.com/0514-7492/article/view/687813
DOI: https://doi.org/10.31857/S0514749225030095
EDN: https://elibrary.ru/EUDZPA
ID: 687813

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Abstract

By the reaction of 2-(benzo[d][1,3]dioxol-5-yl)acetonitrile with dibromobutane and 2,2'-dichlorodiethyl ether, nitriles of 1-(benzo[d][1,3]dioxol-5-yl)cyclopentane- and 4-(benzo[d][1,3]dioxol-5-yl)tetrahydro-2H-pyran-4-carboxylic acids were synthesized, converted into the corresponding acids by alkaline hydrolysis. Targeted (benzo[d][1,3]dioxol-5-yl)cyclopentane(tetrahydropyran)-carboxamides and (benzo[d][1,3]dioxol-5-yl)cyclopentane(tetrahydropyran)-carboxylates were synthesized by interaction of acid chlorides of isolated acids with N,N-dialkylaminoalkyl- and heterylalkylamines, as well as with N,N-dialkylaminoalkyl- and heterylalkylalcohols. The effect of the synthesized compounds on the cardiovascular system and blood hemodynamics was studied.

Keywords

benzo[d][1,3]dioxole, cyclopentane, tetrahydropyran, diaminoalkylamine, aminoalkylalkanol, carboxamide, carboxylate

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