Synthesis of quinolyl substituted thiazolidines and dihydrothiazoles based on 2-{1-[2-methyl-4-(methylthio)-quinolin-3-yl]propan-2-ylidene}hydrazinocarbothioamides substituted in the benzene ring
- Authors: Aleksanyan I.L.1, Hambardzumyan L.P.1
- 
							Affiliations: 
							- Yerevan State University
 
- Issue: Vol 61, No 3 (2025)
- Pages: 302-307
- Section: ЭКСПЕРИМЕНТАЛЬНЫЕ СТАТЬИ
- URL: https://rjeid.com/0514-7492/article/view/687710
- DOI: https://doi.org/10.31857/S0514749225030108
- EDN: https://elibrary.ru/EUFEHE
- ID: 687710
Cite item
Abstract
The diverse biological activity of heterocyclic compounds makes them one of the most important areas of pharmaceuticals and organic synthesis. In this work, a synthesis of new hetarylquinolines containing thiazolidine and dihydrothiazole rings was carried out on the basis of 2-{1-[2-methyl-4-(methylthio)-quinolin-3-yl]propan-2-ylidene}hydrazinocarbothioamides substituted in the benzene ring. The synthesis was conducted using readily available and non-toxic starting materials, ensuring a practical and accessible methodology. The results of this work may serve as a foundation for further studies aimed at exploring the biological and applied potential of these compounds.
Full Text
 
												
	                        About the authors
I. L. Aleksanyan
Yerevan State University
							Author for correspondence.
							Email: ialeksanyan@ysu.am
				                	ORCID iD: 0000-0002-4039-2323
				                																			                												                	Armenia, 							ul. Aleka Manukyana, 1, Yerevan, 375025						
L. P. Hambardzumyan
Yerevan State University
														Email: ialeksanyan@ysu.am
				                	ORCID iD: 0000-0003-1210-0052
				                																			                												                	Armenia, 							ul. Aleka Manukyana, 1, Yerevan, 375025						
References
- Sharma A., Kumar N., Gulati H.K. Rana,R., Aanchal Khanna J., Yatinder M., Singh V., Mohinder Singh P., Mol. Divers. 2024, 28, 4609–4633. doi: 10.1007/s11030-023-10793-6
- Patnam N., Chevula, K., Chennamsetti P., Aleta B., Kote A.K., Manga V., Mol. Divers. 2024, 28, 1551–1563. doi: 10.1007/s11030-023-10674-y
- Majed A.A., Abdalzahra Q.R., Al-Hujaj, H.H., Abid D.S., Alomari A.A., Islam M. Abdellah I.M., Elhenawy A.A., Chem. Select. 2024, 9, e202403761. doi: 10.1002/slct.202403761
- Talluh A.W.A.S., Saleh J.N., Saleh M.J., World of Science: J. Modern Res. Technol. 2024, 3, 49–57. https://univerpubl.com/index.php/woscience
- Sediek A.A., Kassem A.F., Abdel-Aziz M.S., and Younis A., Synthetic Commun. 2024, 54, 1376–1387. doi: 10.1080/00397911.2024.2387121
- Ibrayev M.K., Nurkenov O.A., Rakhimberlinova Z.B., Takibayeva A.T., Palamarchuk I.V., Turdybekov D.M., Kelmyalene A.A., Kulakov I.V., Molecules. 2022, 27, 7598, 1–16. doi: 10.3390/molecules27217598
- Arshad M.F., Alam A., Alshammari A.A., Alhazza M.B., Alzimam I.M., Alam M.A., Mustafa G., Ansari M.S., Alotaibi A.M., Alotaibi A. A., Kumar K., Asdaq, S.M.B, Imran M., Deb, K.P., Venugopala K.N., Jomah S., Molecules. 2022, 27, 3994, 2–54. doi: 10.3390/molecules27133994
- Kumar S., Arora A., Sapra S, Kumar R., Singh B.K., Singh S.K., RSC Adv. 2024, 14, 902–953. doi: 10.1039/D3RA06444A
- Hernández-Ayala L.F., Guzmán-López E.G., Galano A., Antioxidants. 2023, 12, 1853, 2–17. doi: 10.3390/antiox12101853
- Ajani O.O., Iyaye K.T. and Ademosun O.T., RSC Adv. 2022, 12, 18594–18614. doi: 10.1039/D2RA02896D
- Kumar S., Bawa S., Bawa S., Mini-Reviews Med. Chem. 2009, 9, 1648–1654. doi: 10.2174/138955709791012247
- Hussein M., Kafafy A.H., Abdel-Moty S., Abou-Gha-dir O., Acta Pharmaceutica. 2009, 59, 365–382. doi: 10.2478/v10007-009-0033-8
- Golea L., Chebaki j., Laabassi M., Mosset P., Chem. Data Collect. 2023, 43, 100977, 1–13. doi: 10.1016/j.cdc.2022.100977.
- Eissa S.I., Farrag A.M., Abbas S.Y., El Shehry M.F., Ragab A., Fayed E.M., Ammar Y.A., Bioorg. Chem. 2021, 110, 104803, 1–13. doi: 10.1016/j.bioorg.2021.104803.
- Paisuwan W., Srithadindang K., Kodama T., Sukwattanasinitt M., Tobisu, M., Ajavakom A. Spectrochimica Acta Part A: Mol. Biomol. Spectroscopy. 2024, 322, 124706, 1–11. doi 10.1016 /j.saa.2024.124706.
- Lewinska G., Sanetra J., Marszalek K.W., J. Mater. Sci.: Mater. Electron. 2021, 32, 18451–18465. doi: 10.1007/s10854-021-06225-6.
- Răsădean D., Quesnel Filippou P.S., Dan Pantoş D., Dey P., Chem. Materials. 2023, 35, 4988–4997. doi: 10.1021/acs.chemmater.3c00336
- Shyamsivappan S., Saravanan A., Vandana N., Suresh T., Suresh S., Nandhakumar R., Nandhakumar R., Mohan P.S., ACS Omega. 2020, 5, 27245–27253. doi: 10.1021/acsomega.0c03445
- Wallace D.R., Encyclopedia of Toxicology. 4th Ed., Academic Press, Tulsa, OK, United States. 2024, 111–116. doi: 10.1016/B978-0-12-824315-2.00575-3.
- Wallace D.R., Encyclopedia of Toxicology. 3rd Ed., Academic Press, Tulsa, OK, United States. 2014, 23–25. doi: 10.1016/B978-0-12-386454-3.00193-7.
- Cai Q., Song H., Zhang Y., Zhu Z., Zhang J., Chen J., Agric. Food Chem. 2024, 72, 12373–12386. doi: 10.1021/acs.jafc.4c01582
- Panchal N.B. and Vaghela V.M., Orient. J. Chem. 2023, 39, 546–567. doi: 10.13005/ojc/390303
- Litim B., Djahoudi A., Meliani S., Boukhari A., Med. Chem. Res. 2022, 31, 60–74. doi: 10.1007/s00044-021-02815-5
- Bhanwala N., Gupta V., Chandrakar L., Gopal K.L., Chem. Select. 2023, 8, 46, e202302803. doi: 10.1002/slct.202302803
- Rana R., Kumar N., Gulati H.K., Sharma A., Khanna A., Badhwar P.R., Dhir M., Vir Singh J.J., Singh Bedi P.M., J. Mol. Struct. 2023, 1292, 136194, 1–35. doi: 10.1016/j.molstruc.2023.136194.
- Алексанян И.Л., Амбарцумян Л.П., ЖOрХ. 2021, 57, 1170–1176. doi 10.318557/S0514792210080085 [Aleksanyan I.L., Hambardzumyan L.P., Russ. J. Org. Chem. 2021, 57, 1289–1294.] doi: 10.1134/S107042802108008X
- Алексанян И.Л., Амбарцумян Л.П., ЖOрХ. 2024, 60, 62–68. [Aleksanyan I.L., Hambardzumyana L.P., Russ. J. Org. Chem. 2024, 60, 1585–1590.] doi: 10.1134/S1070428024080025
 
				
			 
					 
						 
						 
						 
						 
									

 
  
  
  Email this article
			Email this article 
 Open Access
		                                Open Access Access granted
						Access granted
