Synthesis and antioxidant activity furan derivatives containing 1,3,4-oxadiazole ring

A. A. Aghekyan; Агекян Aся Aгековна; H. A. Panosyan; Паносян Генрих Агавардович; Zh. M. Buniatyan; Буниатян Жанна Мамиконовна; R. E. Muradyan; Мурадян Рафаэль Егиазарович; G. G. Mkryan; Мкрян Геворг Гургенович

doi:10.31857/S0514749224050045

Synthesis and antioxidant activity furan derivatives containing 1,3,4-oxadiazole ring

作者: Aghekyan A.A.¹, Panosyan H.A.¹, Buniatyan Z.M.¹, Muradyan R.E.¹, Mkryan G.G.¹
隶属关系:
1. The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
期: 卷 60, 编号 5 (2024)
页面: 614-622
栏目: Articles
URL: https://rjeid.com/0514-7492/article/view/685340
DOI: https://doi.org/10.31857/S0514749224050045
EDN: https://elibrary.ru/RDHUFK
ID: 685340

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N-methylaminoamide derivatives were obtained by the reaction of methyl esters of 5-aminomethyl-substituted furocarboxylic acids with methylamine, and the corresponding amino acids were isolated by hydrolysis. Hydrazides were synthesized by interaction above mention esters with hydrazine hydrate, which were converted via diamide derivatives into biheterocyclic compounds containing furan and 1,3,4-oxadiazole rings. The target biheterocycles were also synthesized by the reaction of hydrazides with acid chlorides in the presence of phosphorus oxychloride in one stage without isolating diamides.

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furan, hydrazide, phosphorus oxychloride, cyclization, 1,3,4-oxadiazole

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