Synthesis of Amides Based on Biologically Active 5Z,9Z-Eicosadienoic Acid

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Abstract

For the first time, amides of (5Z,9Z)-eicosa-5,9-dienoic acid, which exhibits a high inhibitory activity of topoisomerases I and II, were synthesized using aliphatic and O-containing 1,2-dienes at the key stage of the intermolecular cross-cyclomagnesiation reaction, catalyzed by Cp2TiCl2.

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About the authors

E. Kh. Makarova

Institute of Petrochemistry and Catalysis of the Ufa Federal Research Center of the Russian Academy of Sciences

Author for correspondence.
Email: makarovaelina87@gmail.com
ORCID iD: 0000-0001-7481-0880
Russian Federation, 141, Oktyabr Ave., Ufa, 450075

A. A. Makarov

Institute of Petrochemistry and Catalysis of the Ufa Federal Research Center of the Russian Academy of Sciences

Email: makarovaelina87@gmail.com
ORCID iD: 0000-0001-7870-2334
Russian Federation, 141, Oktyabr Ave., Ufa, 450075

U. M. Dzhemilev

Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

Email: makarovaelina87@gmail.com
ORCID iD: 0000-0002-7992-6337
Russian Federation, 47, Leninsky Ave., Moscow, 119991

V. A. Dyakonov

Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences

Email: makarovaelina87@gmail.com
ORCID iD: 0000-0002-7787-5054
Russian Federation, 47, Leninsky Ave., Moscow, 119991

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