Synthesis and Antioxidant Activity (4-(Benzo[d][1,3]-dioxol-6-yl)-tetrahydro-2H-pyran-4-yl)methylsubstituted Aryloxypropanolamines, Aminoamides and Sulfanilamides

Zh. S. Arustamyan; Арустамян Ж. С.; R. E. Margaryan; Маркарян Р. Э.; G. G. Mkryan; Мкрян Г. Г.; A. A. Aghekyan; Агекян А. А.; G. A. Panosyan; Паносян Г. А.; Zh. M. Buniatyan; Буниатян Ж. М.; R. E. Muradyan; Мурадян Р. Е.

doi:10.31857/S0514749224010072

Synthesis and Antioxidant Activity (4-(Benzo[d][1,3]-dioxol-6-yl)-tetrahydro-2H-pyran-4-yl)methylsubstituted Aryloxypropanolamines, Aminoamides and Sulfanilamides

Authors: Arustamyan Z.S.¹, Margaryan R.E.¹, Mkryan G.G.¹, Aghekyan A.A.¹, Panosyan G.A.¹, Buniatyan Z.M.¹, Muradyan R.E.¹
Affiliations:
1. The Scientific Technological Centre of Organic and Pharmaceutical Chemistry NAS RA
Issue: Vol 60, No 1 (2024)
Pages: 86-93
Section: Articles
URL: https://rjeid.com/0514-7492/article/view/672237
DOI: https://doi.org/10.31857/S0514749224010072
EDN: https://elibrary.ru/ENFSQA
ID: 672237

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Abstract

Alkylation of 3,4-methylenedioxyphenylacetоnitrile with 2,2-dichlorodiethyl ether gave the corresponding nitrile the reduction of which with lithium aluminum hydride isolated (4-(benzo[d][1,3]dioxol-6-yl)-tetrahydro-2H-pyran-4-yl)methylamine. The interaction of the latter with aryloxymethyloxiranes gave the corresponding 1-((4-(benzo[d][1,3]dioxol-6-yl)-tetrahydro-2H-pyran-4-yl)methylamino)-3-aryloxypropan-2-ols. By the reaction of the same amine with chloroacetyl chloride isolated chloroacetamide, the interaction of which with a variety of secondary amines and heterylthiols synthesized the corresponding substituted amino- and sulfanylacetamides - derivatives of (4-(benzo[d][1,3]dioxol-6-yl)-tetrahydro-2H-pyran-4-yl)methylamine. The antioxidant activity of the obtained compounds was studied.

Keywords

(4-(benzo[d][1,3]dioxol-6-yl)-tetrahydro-2H-pyran-4-yl)methylamine, aryloxyaminopropanol, aminoamide, sulfanilamide

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